Fatty acids and their prostaglandin derivatives: inhibitors of proliferation in aortic smooth muscle cells.

Prostaglandins are synthesized from eicosa-8,11,14-trienoic acid and eicosa-5,8,11-14-tetraenoic acid by smooth muscle cell cultures from guinea pig aorta. Production is inhibited by indomethacin. The precursor fatty acids and their prostaglandin derivatives inhibit proliferation of the cell cultures. The relative availability of fatty acids for prostaglandin biosynthesis may represent a control mechanism for cell proliferation.

[1]  A. Fulco.  Metabolic alterations of fatty acids. , 1974, Annual review of biochemistry.

[2]  G. S. Johnson,et al.  Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5'-monophosphate levels in fibroblasts. , 1972, The Journal of biological chemistry.

[3]  R. Cotran,et al.  Human vascular smooth muscle in culture. Growth and ultrastructure. , 1975, Laboratory investigation; a journal of technical methods and pathology.

[4]  W. Insull,et al.  Cholesteryl ester-rich inclusions from human aortic fatty streak and fibrous plaque lesions of atherosclerosis. I. Crystalline properties, size and internal structure. , 1974, The American journal of pathology.

[5]  D. Cornwell,et al.  Properties of cholesteryl esters in pure and mixed monolayers. , 1971, Journal of lipid research.

[6]  D. Cornwell,et al.  Position of double bonds in the fatty acids of cholesterol esters from human aorta. , 1970, Atherosclerosis.

[7]  L. Levine,et al.  Specificities of Prostaglandins B1, F1α, and F2α Antigen-Antibody Reactions , 1971 .

[8]  R. Ross.  The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. , 1971 .

[9]  L. Taylor,et al.  The role of adenosine 3':5'-cyclic monophosphate in the division of WI 38 cells. The cellular response to prostaglandin E1 and the effects of an cyclic adenosine 3':5'-cyclic monophosphate analogue and prostaglandin E1 on cell division. , 1974, The Biochemical journal.

[10]  W. Seifert,et al.  Cyclic GMP and cyclic AMP levels in normal and transformed fibroblasts , 1974, Nature.

[11]  A. Tashjian,et al.  Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin. , 1972, Biochemical and biophysical research communications.

[12]  B. Jaffe,et al.  The relationship between concentration of prostaglandin E and rates of cell replication. , 1974, Experimental cell research.

[13]  R. Ross,et al.  Atherosclerosis and the Arterial Smooth Muscle Cell , 1973 .