Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics.
暂无分享,去创建一个
Hannes H. Loeffler | Martyn D Winn | Johannes Kästner | Marisa L Martin-Fernandez | M. Martin-Fernandez | S. Roberts | M. Winn | J. Kästner | Hannes H Loeffler | Selene K Roberts
[1] G. Ciccotti,et al. Numerical Integration of the Cartesian Equations of Motion of a System with Constraints: Molecular Dynamics of n-Alkanes , 1977 .
[2] W. L. Jorgensen,et al. Comparison of simple potential functions for simulating liquid water , 1983 .
[3] H. Berendsen,et al. Molecular dynamics with coupling to an external bath , 1984 .
[4] J. Schlessinger. The epidermal growth factor receptor as a multifunctional allosteric protein. , 1988, Biochemistry.
[5] Joseph Schlessinger,et al. Signal transduction by receptors with tyrosine kinase activity , 1990, Cell.
[6] S. South,et al. Tyrosine kinase activity in Pseudomonas aeruginosa , 1994, Molecular microbiology.
[7] K Schulten,et al. VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.
[8] H. Berendsen,et al. Model‐free methods of analyzing domain motions in proteins from simulation: A comparison of normal mode analysis and molecular dynamics simulation of lysozyme , 1997, Proteins.
[9] H. Berendsen,et al. Systematic analysis of domain motions in proteins from conformational change: New results on citrate synthase and T4 lysozyme , 1998, Proteins.
[10] Alexander D. MacKerell,et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.
[11] David C. Lee,et al. Mutagenesis Reveals a Role for Epidermal Growth Factor Receptor Extracellular Subdomain IV in Ligand Binding* , 1999, The Journal of Biological Chemistry.
[12] J. Richardson,et al. Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation. , 1999, Journal of molecular biology.
[13] Alexander D. MacKerell,et al. An Improved Empirical Potential Energy Function for Molecular Simulations of Phospholipids , 2000 .
[14] R. Jorissen,et al. Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor , 2008, Protein science : a publication of the Protein Society.
[15] Y. Yarden,et al. Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.
[16] Jae-Hoon Kim,et al. Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains , 2002, Cell.
[17] A. Berezov,et al. Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics* , 2002, The Journal of Biological Chemistry.
[18] Hyun-soo Cho,et al. Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether , 2002, Science.
[19] Edouard C. Nice,et al. Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α , 2002, Cell.
[20] Hyun-soo Cho,et al. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. , 2003, Molecular cell.
[21] Wei Zhang,et al. A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations , 2003, J. Comput. Chem..
[22] A. Citri,et al. The deaf and the dumb , 2003 .
[23] Tony Pawson,et al. Specificity in Signal Transduction From Phosphotyrosine-SH2 Domain Interactions to Complex Cellular Systems , 2004, Cell.
[24] Peter Klein,et al. The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[25] Kevin Cowtan,et al. research papers Acta Crystallographica Section D Biological , 2005 .
[26] Yosef Yarden,et al. Hsp90 restrains ErbB‐2/HER2 signalling by limiting heterodimer formation , 2004, EMBO reports.
[27] J. Beechem,et al. Preparation and characterization of Alexa Fluor 594-labeled epidermal growth factor for fluorescence resonance energy transfer studies: application to the epidermal growth factor receptor. , 2004, Analytical biochemistry.
[28] Nathan E Hall,et al. CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor* , 2004, Journal of Biological Chemistry.
[29] Laxmikant V. Kalé,et al. Scalable molecular dynamics with NAMD , 2005, J. Comput. Chem..
[30] H. Lane,et al. ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors , 2005, Nature Reviews Cancer.
[31] R. Landgraf,et al. Oligomers of ERBB3 Have Two Distinct Interfaces That Differ in Their Sensitivity to Disruption by Heregulin* , 2005, Journal of Biological Chemistry.
[32] H. Lane,et al. ERBB receptors and cancer: the complexity of targeted inhibitors , 2005, Nature Reviews Cancer.
[33] Cheng Luo,et al. Computational analysis of molecular basis of 1:1 interactions of NRG‐1β wild‐type and variants with ErbB3 and ErbB4 , 2005, Proteins.
[34] P. Aller,et al. Molecular dynamics (MD) investigations of preformed structures of the transmembrane domain of the oncogenic Neu receptor dimer in a DMPC bilayer , 2005, Biopolymers.
[35] Holger Gohlke,et al. The Amber biomolecular simulation programs , 2005, J. Comput. Chem..
[36] Jan H. Jensen,et al. Very fast empirical prediction and rationalization of protein pKa values , 2005, Proteins.
[37] György Vereb,et al. Molecular modeling of nearly full-length ErbB2 receptor. , 2005, Biophysical journal.
[38] Edouard C. Nice,et al. Ligand-induced Dimer-Tetramer Transition during the Activation of the Cell Surface Epidermal Growth Factor Receptor-A Multidimensional Microscopy Analysis* , 2005, Journal of Biological Chemistry.
[39] The transmembrane domain of the oncogenic mutant ErbB-2 receptor: a structure obtained from site-specific infrared dichroism and molecular dynamics. , 2006, Journal of molecular biology.
[40] A. Citri,et al. EGF–ERBB signalling: towards the systems level , 2006, Nature Reviews Molecular Cell Biology.
[41] Jeremy Purvis,et al. A Multiscale Computational Approach to Dissect Early Events in the Erb Family Receptor Mediated Activation, Differential Signaling, and Relevance to Oncogenic Transformations , 2007, Annals of Biomedical Engineering.
[42] P. Aller,et al. Transmembrane Helix Packing of ErbB/Neu Receptor in Membrane Environment: A Molecular Dynamics Study , 2006, Journal of biomolecular structure & dynamics.
[43] John Kuriyan,et al. An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor , 2006, Cell.
[44] D. Tieleman,et al. The MARTINI force field: coarse grained model for biomolecular simulations. , 2007, The journal of physical chemistry. B.
[45] A. Clayton,et al. Unligated epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding. , 2007, Biochemistry.
[46] K. Furuuchi,et al. Targeted Antireceptor Therapy with Monoclonal Antibodies Leads to the Formation of Inactivated Tetrameric Forms of ErbB Receptors1 , 2007, The Journal of Immunology.
[47] Peter V Coveney,et al. Monotopic enzymes and lipid bilayers: a comparative study. , 2007, Biochemistry.
[48] Erez M. Bublil,et al. The EGF receptor family : spearheading a merger of signaling and therapeutics , 2007 .
[49] E. Elson,et al. Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysis. , 2007, Biophysical journal.
[50] P. Nagy,et al. Quantitative characterization of the large-scale association of ErbB1 and ErbB2 by flow cytometric homo-FRET measurements. , 2008, Biophysical journal.
[51] M. Karttunen,et al. Nonpolar interactions between trans‐membrane helical EGF peptide and phosphatidylcholines, sphingomyelins and cholesterol. Molecular dynamics simulation studies , 2008, Journal of peptide science : an official publication of the European Peptide Society.
[52] R. Larson,et al. The MARTINI Coarse-Grained Force Field: Extension to Proteins. , 2008, Journal of chemical theory and computation.
[53] M. Jansson,et al. The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility , 2008, Proceedings of the National Academy of Sciences.
[54] Roman G. Efremov,et al. Spatial Structure of the Dimeric Transmembrane Domain of the Growth Factor Receptor ErbB2 Presumably Corresponding to the Receptor Active State* , 2008, Journal of Biological Chemistry.
[55] M. Genest,et al. Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search , 2008, European Biophysics Journal.
[56] Martyn D Winn,et al. Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells. , 2008, Biophysical journal.
[57] A. Burgess,et al. Predominance of activated EGFR higher-order oligomers on the cell surface , 2008, Growth factors.
[58] Ron Bose,et al. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. , 2008, Structure.
[59] K. Itoh,et al. Tyrosine Kinase Activity of Epidermal Growth Factor Receptor Is Regulated by GM3 Binding through Carbohydrate to Carbohydrate Interactions* , 2009, Journal of Biological Chemistry.
[60] J. Schlessinger,et al. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.