Prion protein interaction with glycosaminoglycan occurs with the formation of oligomeric complexes stabilized by Cu(II) bridges.

[1]  D. Dormont,et al.  Identification of interaction domains of the prion protein with its 37‐kDa/67‐kDa laminin receptor , 2001, The EMBO journal.

[2]  Y. Shaked,et al.  A Protease-resistant Prion Protein Isoform Is Present in Urine of Animals and Humans Affected with Prion Diseases* , 2001, The Journal of Biological Chemistry.

[3]  Pauline M. Rudd,et al.  Antibodies inhibit prion propagation and clear cell cultures of prion infectivity , 2001, Nature.

[4]  M. Enari,et al.  Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J. Collinge,et al.  Location and properties of metal-binding sites on the human prion protein , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  S. Prusiner,et al.  Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Fred E. Cohen,et al.  Folding of Prion Protein to Its Native α-Helical Conformation Is under Kinetic Control* , 2001, The Journal of Biological Chemistry.

[8]  Z. Meiner,et al.  Reconstitution of Prion Infectivity from Solubilized Protease-resistant PrP and Nonprotein Components of Prion Rods* , 2001, The Journal of Biological Chemistry.

[9]  B. Chesebro,et al.  Sulfated glycans and elevated temperature stimulate PrPSc‐dependent cell‐free formation of protease‐resistant prion protein , 2001, The EMBO journal.

[10]  F. Cohen,et al.  Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry , 2008, Protein science : a publication of the Protein Society.

[11]  F. Cohen,et al.  Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy. , 2000, Biochemistry.

[12]  K Wüthrich,et al.  NMR structure of the bovine prion protein. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Gasset,et al.  Refolding and characterization of rat liver methionine adenosyltransferase from Escherichia coli inclusion bodies. , 2000, Protein expression and purification.

[14]  D. Westaway,et al.  Copper(II)-induced Conformational Changes and Protease Resistance in Recombinant and Cellular PrP , 2000, The Journal of Biological Chemistry.

[15]  D. Dormont,et al.  Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent , 2000, Journal of Virology.

[16]  J. Peng,et al.  An NMR and molecular modeling study of the site-specific binding of histamine by heparin, chemically modified heparin, and heparin-derived oligosaccharides. , 2000, Biochemistry.

[17]  J. Upritchard,et al.  Oxidation of heparin-treated low density lipoprotein by peroxidases. , 1999, Atherosclerosis.

[18]  C. Bostock,et al.  Characterization and polyanion-binding properties of purified recombinant prion protein. , 1999, The Biochemical journal.

[19]  H. Takeuchi,et al.  Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence. , 1999, Biochemistry.

[20]  Y. Nagasaka,et al.  Oxidative modification of apolipoprotein E in human very-low-density lipoprotein and its inhibition by glycosaminoglycans. , 1999, Archives of biochemistry and biophysics.

[21]  C. Soto,et al.  Cell-lysate conversion of prion protein into its protease-resistant isoform suggests the participation of a cellular chaperone. , 1999, Biochemical and biophysical research communications.

[22]  F. Cohen,et al.  Copper binding to the prion protein: structural implications of four identical cooperative binding sites. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[23]  C. Korth,et al.  Monoclonal antibodies specific for the native, disease-associated isoform of the prion protein. , 1999, Methods in enzymology.

[24]  S. Prusiner,et al.  Rapid Acquisition of β-Sheet Structure in the Prion Protein Prior to Multimer Formation , 1998, Biological chemistry.

[25]  J. Ávila,et al.  Sulphated glycosaminoglycans prevent the neurotoxicity of a human prion protein fragment. , 1998, The Biochemical journal.

[26]  J. Aiken,et al.  Reversibility of Scrapie Inactivation Is Enhanced by Copper* , 1998, The Journal of Biological Chemistry.

[27]  F. Cohen,et al.  Eight prion strains have PrPSc molecules with different conformations , 1998, Nature Medicine.

[28]  F. Cohen,et al.  Prion protein selectively binds copper(II) ions. , 1998, Biochemistry.

[29]  W. T. Morgan,et al.  Histidine-Proline-rich Glycoprotein as a Plasma pH Sensor , 1998, The Journal of Biological Chemistry.

[30]  J. Weiler,et al.  Glycosaminoglycan‐protein interactions: definition of consensus sites in glycosaminoglycan binding proteins , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.

[31]  D. Westaway,et al.  The cellular prion protein binds copper in vivo , 1997, Nature.

[32]  M. Gasset,et al.  Conformational features and thermal stability of bovine seminal plasma protein PDC-109 oligomers and phosphorylcholine-bound complexes. , 1997, European journal of biochemistry.

[33]  G. Friedlander,et al.  Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform* , 1997, The Journal of Biological Chemistry.

[34]  K. Moulder,et al.  Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells (*) , 1995, The Journal of Biological Chemistry.

[35]  F. Cohen,et al.  Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein , 1995, Cell.

[36]  Richard L. Stevens,et al.  Packaging of Proteases and Proteoglycans in the Granules of Mast Cells and Other Hematopoietic Cells , 1995, The Journal of Biological Chemistry.

[37]  D. Teplow,et al.  Truncated Forms of the Human Prion Protein in Normal Brain and in Prion Diseases (*) , 1995, The Journal of Biological Chemistry.

[38]  S. Prusiner,et al.  Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501] , 1995, The Journal of cell biology.

[39]  G. J. Raymond,et al.  Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected] , 1994, Journal of virology.

[40]  R J Fletterick,et al.  Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[41]  S. Ben‐Sasson,et al.  Heparin‐like molecules bind differentially to prion‐proteins and change their intracellular metabolic fate , 1993, Journal of cellular physiology.

[42]  G. J. Raymond,et al.  Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells , 1993, Journal of virology.

[43]  S. Prusiner,et al.  Evidence for synthesis of scrapie prion proteins in the endocytic pathway. , 1992, The Journal of biological chemistry.

[44]  J. Choay,et al.  Heavy metal binding to heparin disaccharides. I. Iduronic acid is the main binding site , 1992, Biopolymers.

[45]  G. S. Manning,et al.  Theory of delocalized ionic binding to polynucleotides: Structural and excluded‐volume effects , 1992, Biopolymers.

[46]  D. Grant,et al.  Cu(2+)-heparin interaction studied by polarimetry. , 1992, The Biochemical journal.

[47]  D. F. Ogletree,et al.  Atomic force microscopy imaging of T4 bacteriophages on silicon substrates. , 1991, Ultramicroscopy.

[48]  S. Prusiner,et al.  Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[49]  E Goormaghtigh,et al.  Secondary structure and dosage of soluble and membrane proteins by attenuated total reflection Fourier-transform infrared spectroscopy on hydrated films. , 1990, European journal of biochemistry.

[50]  Y. Tajima,et al.  Phosphotungstate as a useful eluent for antithrombin III purification by heparin-agarose affinity chromatography. , 1990, Thrombosis research.

[51]  Y. Tajima,et al.  Phosphotungstate shows a heparin-like anticoagulant effect but inhibits heparin. , 1989, Thrombosis research.

[52]  A. Cardin,et al.  Molecular Modeling of Protein‐Glycosaminoglycan Interactions , 1989, Arteriosclerosis.

[53]  J. O. Baker [6] Metal-buffered systems , 1988 .

[54]  R. Kimberlin,et al.  Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions , 1986, Antimicrobial Agents and Chemotherapy.

[55]  A. Dickinson,et al.  Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection. , 1986, The Journal of general virology.

[56]  H. Diringer,et al.  Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. , 1984, The Journal of general virology.

[57]  G. S. Manning The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides , 1978, Quarterly Reviews of Biophysics.

[58]  S. Stivala,et al.  Interaction of the polyelectrolyte heparin with copper(II) and calcium , 1973, Biopolymers.