Chemotherapy of experimental streptococcal endocarditis. II. Synergism between penicillin and streptomycin against penicillin-sensitive streptococci.

Bacterial endocarditis was produced by intravenous injection of Streptococcus viridans into rabbits with preexisting sterile endocardial vegetations. After 6 h had elapsed, bacteria in the vegetations could not be eradicated by brief treatment with antimicrobials to which the streptococci were sensitive. However, when treatment with penicillin was continued for 4 days, the animals were cured. The 6-h infection therefore offered a model in which treatments could be conveniently compared over a short period. Synergism was demonstrated between penicillin and streptomycin in endocarditis due to a fully penicillin-sensitive streptococcus, a point which had not been previously proved in vivo. The clinical implications are discussed.

[1]  O. O. Meyer,et al.  EXPERIENCES WITH PENICILLIN AND DICUMAROL IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS* , 1947, The American journal of the medical sciences.

[2]  P. Y. Paterson,et al.  Bacterial endocarditis. , 1956, Disease-a-month : DM.

[3]  D. Durack,et al.  Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. , 1973, British journal of experimental pathology.

[4]  J. Geraci The Antibiotic Therapy of Bacterial Endocarditis: Therapeutic Data on 172 Patients Seen frOIll 1951 Through 1957: Additional Observations on Short-TerIll Therapy (Two Weeks) for Penicillin- Sensitive Streptococcal Endocarditis , 1958 .

[5]  N. Korn,et al.  A Comparison of the Postoperative Bacteremias Induced Following Different Periodontal Procedures , 1962 .

[6]  D. Durack,et al.  Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. , 1973, The Journal of clinical investigation.

[7]  R. Glaser,et al.  Effect of penicillin on the bacteremia following dental extraction. , 1948, The American journal of medicine.

[8]  D. Durack,et al.  Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. , 1972, British journal of experimental pathology.

[9]  Francis O'Grady,et al.  ANTIBIOTIC AND CHEMOTHERAPY , 1974, The Ulster Medical Journal.

[10]  R. Petersdorf,et al.  I. COMPARISON OF COMMONLY RECOMMENDED PROPHYLACTIC REGIMENS , 1973 .

[11]  T. Hunter The treatment of some bacterial infections of the heart and pericardium. , 1952, Bulletin of the New York Academy of Medicine.

[12]  H. Dowling,et al.  SUCCESSFUL SHORT‐TERM THERAPY OF STREPTOCOCCAL ENDOCARDITIS WITH PENICILLIN AND STREPTOMYCIN , 1955, The American journal of the medical sciences.

[13]  S. Kaplan,et al.  Successful two-week treatment schedule for penicillin-susceptible streptococcus viridans endocarditis. , 1971, Lancet.

[14]  R. Tompsett DIAGNOSIS AND TREATMENT OF BACTERIAL ENDOCARDITIS. , 1964, Disease-a-month : DM.

[15]  T. Hunter Use of streptomycin in the treatment of bacterial endocarditis. , 1947, The American journal of medicine.

[16]  O. Khairat The Non-Aerobes of Post-Extraction Bacteremia , 1966, Journal of dental research.

[17]  W. P. Harvey,et al.  Bacterial endocarditis related to cleaning and filling of teeth with particular reference to the inadequacy of present day knowledge and practice of antibiotic prophylaxis for all dental procedures. , 1961, The American journal of cardiology.

[18]  E. Benner,et al.  Simplified, accurate method for antibiotic assay of clinical specimens. , 1966, Applied microbiology.

[19]  L. Garrod Bactericidal Action of Streptomycin , 1948, British medical journal.

[20]  J. Geraci ANTIBIOTIC THERAPY OF BACTERIAL ENDOCARDITIS. , 1963, The Heart bulletin.

[21]  L. R. Freedman,et al.  Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. , 1970, The Yale journal of biology and medicine.