Maturation of the Macroreticulocyte

With anaemia the erythroid marrow maturation pattern of the rat is altered so that macroreticulocytes containing increased amounts of haemoglobin, water, ribosomes and ribonucleic acid are released into circulation. This was shown to be accompanied by a reduction in the marrow iron transit time, a measurement of the maturation time of marrow reticulocytes, and possibly by the occurrence of skipped mitoses during maturation. Despite the premature release, increased volume and haemoglobin content of these macroreticulocytes, they matured normally without apparent splenic sequestration or significant cell death in the first 10 days. At the same time they underwent shrinkage by loss of both cell water and some haemoglobin. This appeared to be an intravascular phenomenon where macrocytes were remodelled, possibly by cell fragmentation, until a population with near normal indices was obtained.

[1]  R. Hillman.  Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia. , 1969, The Journal of clinical investigation.

[2]  R. Hillman,et al.  Characteristics of vitamin B12 correction of the abnormal erythropoiesis of pernicious anemia. , 1968, Blood.

[3]  Hill Rs,et al.  Erythropoiesis: normal and abnormal. , 1967, Seminars in hematology.

[4]  R. Card,et al.  Characteristics of shortened survival of stress erythrocytes in the rabbit. , 1967, The American journal of physiology.

[5]  S. Piomelli,et al.  The mechanism of red cell aging. I. Relationship between cell age and specific gravity evaluated by ultracentrifugation in a discontinuous density gradient. , 1967, The Journal of laboratory and clinical medicine.

[6]  R. Weed,et al.  Membrane alterations leading to red cell destruction. , 1966, The American journal of medicine.

[7]  L. Lajtha,et al.  Direct Effects of Erythropoietin on the Bone Marrow of the Isolated Perfused Hind Limbs of Rabbits , 1965, British journal of haematology.

[8]  M. Miyahara,et al.  MACROCYTOSIS RESULTING FROM EARLY DENUCLEATION OF ERYTHROID PRECURSORS. , 1964, Blood.

[9]  F. Stohlman,et al.  Humoral Regulation of Erythropoiesis VII. Shortened Survival of Erythrocytes Produced by Erythropoietine or Severe Anemia , 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[10]  G. Brecher,et al.  Reticulocyte Size and Erythropoietic Stimulation , 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[11]  E. Morgan,et al.  Plasma iron and iron-binding capacity levels in health and disease: with an improved method for the estimation of plasma iron concentration and total iron-binding capacity. , 1960, Australasian annals of medicine.

[12]  I. Pannacciulli,et al.  The maturation rate of reticulocytes. , 1960, Blood.

[13]  E. Ambs.  [On large and hemoglobin-rich reticulocytes in crises in anemias]. , 1960, Schweizerische medizinische Wochenschrift.

[14]  L M LOWENSTEIN,et al.  The mammalian reticulocyte. , 1959, International review of cytology.

[15]  C. Finch,et al.  The relative number of marrow reticulocytes. , 1958, American journal of clinical pathology.

[16]  T. Bothwell,et al.  The determination of iron in plasma or serum. , 1955, The Biochemical journal.

[17]  N I BERLIN,et al.  Life Span of the Red Blood Cell of the Rat Following Acute Hemorrhage.∗ , 1951, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.