Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors.

[1]  A. Wadood,et al.  Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies. , 2020, Bioorganic & medicinal chemistry.

[2]  M. Knorr,et al.  Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity , 2020, Molecules.

[3]  S. Ignacimuthu,et al.  Synthesis of a 1,2,3-bistriazole derivative of embelin and evaluation of its effect on high-fat diet fed-streptozotocin-induced type 2 diabetes in rats and molecular docking studies. , 2020, Bioorganic chemistry.

[4]  Wei Li,et al.  Bioactivity-based analysis and chemical characterization of hypoglycemic and antioxidant components from Artemisia argyi. , 2019, Bioorganic chemistry.

[5]  Vikramdeep Monga,et al.  Synthesis and biological evaluation of thiazolidine-2,4-dione-pyrazole conjugates as antidiabetic, anti-inflammatory and antioxidant agents. , 2019, Bioorganic chemistry.

[6]  N. Uddin,et al.  Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies. , 2019, Bioorganic chemistry.

[7]  B. Gulyás,et al.  Muscle extract of Arothron immaculatus regulates the blood glucose level and the antioxidant system in high-fat diet and streptozotocin induced diabetic rats. , 2019, Bioorganic chemistry.

[8]  Sarra Boudriga,et al.  Straightforward and Highly Diastereoselective Synthesis of a New Set of Functionalized Dispiropyrrolidines Involving Multicomponent 1,3‐Dipolar Cycloaddition with Azomethine Ylides , 2019, Journal of Heterocyclic Chemistry.

[9]  A. Barakat,et al.  Spiroindolone Analogues as Potential Hypoglycemic with Dual Inhibitory Activity on α-Amylase and α-Glucosidase , 2019, Molecules.

[10]  Jia Li,et al.  Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors. , 2019, Bioorganic & medicinal chemistry letters.

[11]  M. Knorr,et al.  Highly diastereoselective construction of novel dispiropyrrolo[2,1-a]isoquinoline derivatives via multicomponent 1,3-dipolar cycloaddition of cyclic diketones-based tetrahydroisoquinolinium N-ylides , 2019, RSC advances.

[12]  A. Babapoor,et al.  A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities , 2019, Artificial cells, nanomedicine, and biotechnology.

[13]  D. Du,et al.  Asymmetric Construction of Bispiro[oxindole-pyrrolidine-rhodanine]s via Squaramide-Catalyzed Domino Michael/Mannich [3 + 2] Cycloaddition of Rhodanine Derivatives with N-(2,2,2-Trifluoroethyl)isatin Ketimines. , 2018, The Journal of organic chemistry.

[14]  R. Sawant,et al.  Targeting PPAR-γ to design and synthesize antidiabetic thiazolidines , 2018, EXCLI journal.

[15]  C. Dong,et al.  Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors. , 2018, Bioorganic & medicinal chemistry letters.

[16]  F. Badria,et al.  Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1 , 2018, RSC advances.

[17]  D. Kaminskyy,et al.  Recent developments with rhodanine as a scaffold for drug discovery , 2017, Expert opinion on drug discovery.

[18]  Jin Hwa Kim,et al.  Monotherapy in Patients with Type 2 Diabetes Mellitus , 2017, Diabetes & metabolism journal.

[19]  Hesham A El-Beshbishy,et al.  Albizia harveyi: phytochemical profiling, antioxidant, antidiabetic and hepatoprotective activities of the bark extract , 2017, Medicinal Chemistry Research.

[20]  Guangcheng Wang,et al.  Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives. , 2017, MedChemComm.

[21]  N. Thangavel,et al.  Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs , 2017, International journal of medicinal chemistry.

[22]  San-Lang Wang,et al.  Biosynthesis of α-Glucosidase Inhibitors by a Newly Isolated Bacterium, Paenibacillus sp. TKU042 and Its Effect on Reducing Plasma Glucose in a Mouse Model , 2017, International journal of molecular sciences.

[23]  T. Kawada,et al.  Dietary low‐fat soy milk powder retards diabetic nephropathy progression via inhibition of renal fibrosis and renal inflammation , 2017, Molecular nutrition & food research.

[24]  A. Chaudhury,et al.  Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management , 2017, Front. Endocrinol..

[25]  M. Krátký,et al.  Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors. , 2016 .

[26]  M. Tolentino,et al.  Current and investigational drugs for the treatment of diabetic retinopathy , 2016, Expert opinion on investigational drugs.

[27]  Sunayana Sitaram,et al.  Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study , 2016 .

[28]  M. Knorr,et al.  Stoichiometry-controlled cycloaddition of nitrilimines with unsymmetrical exocyclic dienones: microwave-assisted synthesis of novel mono- and dispiropyrazoline derivatives , 2016 .

[29]  M. Knorr,et al.  Regio- and Stereoselective Synthesis of Spiropyrrolizidines and Piperazines through Azomethine Ylide Cycloaddition Reaction. , 2015, The Journal of organic chemistry.

[30]  H. Ogawa,et al.  Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval through N-Glycan-specific Binding, Endocytosis, and Degradation* , 2015, The Journal of Biological Chemistry.

[31]  Pitchai Balakumar,et al.  A step ahead of PPARγ full agonists to PPARγ partial agonists: therapeutic perspectives in the management of diabetic insulin resistance. , 2015, European journal of pharmacology.

[32]  A. Shafiee,et al.  Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors , 2015, Journal of enzyme inhibition and medicinal chemistry.

[33]  A. Almansour,et al.  A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines , 2015, Molecules.

[34]  G. Sheldrick SHELXT – Integrated space-group and crystal-structure determination , 2015, Acta crystallographica. Section A, Foundations and advances.

[35]  G. Sheldrick Crystal structure refinement with SHELXL , 2015, Acta crystallographica. Section C, Structural chemistry.

[36]  P. Yogeeswari,et al.  Synthesis of novel dispiropyrrolothiazoles by three-component 1,3-dipolar cycloaddition and evaluation of their antimycobacterial activity , 2014 .

[37]  V. Minkin,et al.  Synthesis and antiviral activity of bis-spirocyclic derivatives of rhodanine , 2014, Russian Chemical Bulletin.

[38]  C. Balachandran,et al.  Novel spirooxindole-pyrrolidine compounds: synthesis, anticancer and molecular docking studies. , 2014, European journal of medicinal chemistry.

[39]  R. Ramasamy,et al.  Aldose reductase, oxidative stress and diabetic cardiovascular complications. , 2012, Cardiovascular & hematological agents in medicinal chemistry.

[40]  N. Allouche,et al.  Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats , 2011, Lipids in Health and Disease.

[41]  P. Magalhães,et al.  Application of microbial α-amylase in industry - A review , 2010 .

[42]  N. Neamati,et al.  Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors , 2010, Molecules.

[43]  S. Sriman Narayanan,et al.  Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives. , 2009, European journal of medicinal chemistry.

[44]  I. D. da Silva,et al.  Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. , 2009, European journal of medicinal chemistry.

[45]  Richard J. Gildea,et al.  OLEX2: a complete structure solution, refinement and analysis program , 2009 .

[46]  M. Fowler Microvascular and Macrovascular Complications of Diabetes , 2008, Clinical Diabetes.

[47]  K N Houk,et al.  Distortion/interaction energy control of 1,3-dipolar cycloaddition reactivity. , 2007, Journal of the American Chemical Society.

[48]  M. D. G. Giménez,et al.  Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. , 2007 .

[49]  A. Kitabchi,et al.  Management of type 2 diabetes mellitus. , 2000, Tennessee medicine : journal of the Tennessee Medical Association.

[50]  J. Kawabata,et al.  α-Amylase Inhibitors from Roselle (Hibiscus sabdariffa Linn.) Tea , 2000, Bioscience, biotechnology, and biochemistry.

[51]  N. Hotta,et al.  Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan. , 1996, Journal of diabetes and its complications.

[52]  M. Knorr,et al.  A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies , 2015 .

[53]  K. Houk The role of secondary orbital interactions in cycloaddition reactions , 1970 .