PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury

[1]  Xianqun Fan,et al.  PTEN Inhibition Accelerates Corneal Endothelial Wound Healing through Increased Endothelial Cell Division and Migration , 2020, Investigative ophthalmology & visual science.

[2]  Yantao Wei,et al.  The Morphological Relationship Between Dome-Shaped Macula and Myopic Retinoschisis: A Cross-sectional Study of 409 Highly Myopic Eyes , 2020, Investigative ophthalmology & visual science.

[3]  N. Koizumi,et al.  Regeneration of the Corneal Endothelium , 2019, Current eye research.

[4]  S. Tseng,et al.  Pax 6 Controls Neural Crest Potential of Limbal Niche Cells to Support Self-Renewal of Limbal Epithelial Stem Cells , 2019, Scientific Reports.

[5]  Tao Yu,et al.  SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts , 2019, Oxidative medicine and cellular longevity.

[6]  Meifang Zhu,et al.  Mutual regulation between IGF‐1R and IGFBP‐3 in human corneal epithelial cells , 2018, Journal of cellular physiology.

[7]  Ling Wang,et al.  Differential Expression of Seven De-sumoylation Enzymes (SENPs) in Major Ocular Tissues of Mouse Eye. , 2019, Current molecular medicine.

[8]  Y. Shin,et al.  SOX2 Activation Using CRISPR/dCas9 Promotes Wound Healing in Corneal Endothelial Cells , 2018, Stem cells.

[9]  Feng-Hou Gao,et al.  SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions. , 2018, Biochimie.

[10]  N. Koizumi,et al.  Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy , 2018, The New England journal of medicine.

[11]  R. Xu,et al.  PAX6 Alternative Splicing and Corneal Development. , 2018, Stem cells and development.

[12]  D. P. Singh,et al.  Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation , 2017, Cell Death & Disease.

[13]  C. Sotozono,et al.  PAX6 regulates human corneal epithelium cell identity , 2017, Experimental eye research.

[14]  N. Afshari,et al.  Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models , 2016, Investigative ophthalmology & visual science.

[15]  L. Zhang,et al.  SUMOylation Regulation of Retina Development and Functions. , 2016, Current molecular medicine.

[16]  Chien-Chia Su,et al.  In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition. , 2016, Journal of visualized experiments : JoVE.

[17]  N. Koizumi,et al.  Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing. , 2016, Investigative ophthalmology & visual science.

[18]  S. Ferrari,et al.  Concise Review: An Update on the Culture of Human Corneal Endothelial Cells for Transplantation , 2016, Stem cells translational medicine.

[19]  Chao Huang,et al.  Sequential posttranslational modifications regulate PKC degradation , 2016, Molecular biology of the cell.

[20]  A. Ljubimov,et al.  Progress in corneal wound healing , 2015, Progress in Retinal and Eye Research.

[21]  W. Wee,et al.  Recovery of Corneal Endothelial Cells from Periphery after Injury , 2015, PloS one.

[22]  Xianqun Fan,et al.  The signaling pathway involved in the proliferation of corneal endothelial cells , 2015, Journal of receptor and signal transduction research.

[23]  N. Koizumi,et al.  Effect of the Rho Kinase Inhibitor Y-27632 on Corneal Endothelial Wound Healing. , 2015, Investigative ophthalmology & visual science.

[24]  Tian-Le Xu,et al.  Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation , 2014, Nature Communications.

[25]  Kang Zhang,et al.  WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis , 2014, Nature.

[26]  S. Xiang,et al.  Sumoylation differentially regulates Sp1 to control cell differentiation , 2014, Proceedings of the National Academy of Sciences.

[27]  K. Sonoda,et al.  Bullous Keratopathy as a Progressive Disease: Evidence From Clinical and Laboratory Imaging Studies , 2013, Cornea.

[28]  T. Mimura,et al.  Corneal endothelial regeneration and tissue engineering , 2013, Progress in Retinal and Eye Research.

[29]  F. Melchior,et al.  Sumoylation: a regulatory protein modification in health and disease. , 2013, Annual review of biochemistry.

[30]  J. Mehta,et al.  A mouse model of corneal endothelial decompensation using cryoinjury , 2013, Molecular vision.

[31]  Christopher E. Berndsen,et al.  RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage , 2012, Science Signaling.

[32]  Shigeru Kinoshita,et al.  Corneal transplantation , 2012, The Lancet.

[33]  D. Tan,et al.  Ophthalmology 3 Corneal transplantation , 2012 .

[34]  Luo Lu,et al.  De-SUMOylation of CCCTC Binding Factor (CTCF) in Hypoxic Stress-induced Human Corneal Epithelial Cells* , 2012, The Journal of Biological Chemistry.

[35]  Sanjay V. Patel.  Graft survival and endothelial outcomes in the new era of endothelial keratoplasty. , 2012, Experimental eye research.

[36]  N. Fullwood,et al.  Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis , 2011, PloS one.

[37]  Jinping Liu,et al.  Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development , 2010, Proceedings of the National Academy of Sciences.

[38]  J. Rubenstein,et al.  The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis , 2009, PLoS genetics.

[39]  Anastassia Stoykova,et al.  Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. , 2008, Genes & development.

[40]  J. Collinson,et al.  PAX6 dosage effects on corneal development, growth, and wound healing , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[41]  Y. Hayashida,et al.  Down‐regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases , 2008, The Journal of pathology.

[42]  Jinke Cheng,et al.  SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia , 2007, Cell.

[43]  H. Edelhauser,et al.  Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. , 2007, Molecular vision.

[44]  Yan Liu,et al.  Protein Phosphatase-1 Modulates the Function of Pax-6, a Transcription Factor Controlling Brain and Eye Development* , 2007, Journal of Biological Chemistry.

[45]  Jinke Cheng,et al.  SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. , 2007, Cell.

[46]  R. Hay,et al.  SUMO: a history of modification. , 2005, Molecular cell.

[47]  Erica S. Johnson,et al.  Protein modification by SUMO. , 2004, Annual review of biochemistry.

[48]  M. Dominguez,et al.  Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster , 2004, Nature Genetics.

[49]  N. Joyce.  Proliferative capacity of the corneal endothelium , 2003, Progress in Retinal and Eye Research.

[50]  R. Hill,et al.  The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. , 2003, Developmental biology.

[51]  T Ian Simpson,et al.  Pax6; A pleiotropic player in development , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[52]  A. Cvekl,et al.  Quantitation of PAX6 and PAX6(5a) transcript levels in adult human lens, cornea, and monkey retina. , 2001, Molecular vision.

[53]  Z. Ronai,et al.  SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53 , 2000, Cell.

[54]  O. Sundin,et al.  The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia. , 1997, Investigative ophthalmology & visual science.

[55]  S. Saule,et al.  Identification and Characterization of a Neuroretina-Specific Enhancer Element in the Quail Pax-6 ( Pax-QNR ) Gene , 2022 .

[56]  H. Edelhauser,et al.  Cellular migration and morphology in corneal endothelial wound repair. , 1985, Investigative ophthalmology & visual science.

[57]  H E Kaufman,et al.  Corneal transplantation. , 1977, Annual review of medicine.

[58]  R A Laing,et al.  Changes in the corneal endothelium as a function of age. , 1976, Experimental eye research.