The Impact of Single-Level ACDF on Neural Foramen and Disc Height of Surgical and Adjacent Cervical Segments: A Case-Series Radiological Analysis

Background: ACDF has become one of the established procedures for the surgical treatment of symptomatic cervical spondylosis, showing excellent clinical results and effective improvements in neural functions and neck pain relief. The main purpose of ACDF is neural decompression, and it is considered by some authors as an indirect result of the intervertebral distraction and cage insertion and the consequent restoration of the disc space and foramen height. Methods: Radiological data from 28 patients who underwent single-level ACDF were retrospectively collected and evaluated. For neural foramen evaluation, antero-posterior (A-P) and cranio-caudal (C-C) diameters were manually calculated; for intervertebral disc height the anterior, centrum and posterior measurement were calculated. All measurements were performed at surgical and adjacent (above and below) segments. NRS, NDI and also the mJOA and Nurick scale were collected for clinical examination and complete evaluation of patients’ postoperative outcome. Results: The intervertebral disc height in all its measurements, in addition to the height (C-C diameter) of the foramen (both right and left) increase at the surgical segment when comparing pre and postop results (p < 0.001, and p = 0.033 and p = 0.001). NRS and NDI radiculopathy scores showed improved results from pre- to post-op evaluation (p < 0.001), and a negative statistical correlation with the improved disc height at the surgical level. Conclusions: The restoration of posterior disc height through cage insertion appears to be effective in increasing foraminal height in patients with symptomatic preoperative cervical foraminal stenosis.

[1]  G. Umana,et al.  "White cord syndrome after cervical or thoracic spinal cord decompression. Haemodynamic complication or mechanical damage? An understimated nosographic entity". , 2022, World neurosurgery.

[2]  Y. Meng,et al.  Change in the postoperative intervertebral space height and its impact on clinical and radiological outcomes after ACDF surgery using a zero-profile device: a single-Centre retrospective study of 138 cases , 2021, BMC Musculoskeletal Disorders.

[3]  Changyan Wu,et al.  The effects of cages implantation on surgical and adjacent segmental intervertebral foramina , 2021, Journal of Orthopaedic Surgery and Research.

[4]  W. Yuan,et al.  Predictive Effect of Intervertebral Foramen Width on Pain Relief After ACDF for the Treatment of Cervical Radiculopathy , 2021, Global spine journal.

[5]  W. Anderst,et al.  The effects of age, pathology, and fusion on cervical neural foramen area , 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  Sakae Tanaka,et al.  Anatomical study of cervical intervertebral foramen in patients with cervical spondylotic radiculopathy. , 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[7]  Yuan Xue,et al.  0.5 - 1 Fold Intervertebral Distraction is a Protective Factor for Adjacent Segment Degeneration in Single-Level Anterior Cervical Discectomy and Fusion. , 2020, Spine.

[8]  Yong Shen,et al.  Risk factor analysis of axial symptoms after single-segment anterior cervical discectomy and fusion: A retrospective study of 113 patients , 2019, The Journal of international medical research.

[9]  Xijing He,et al.  Anterior Cervical Corpectomy and Fusion and Anterior Cervical Discectomy and Fusion Using Titanium Mesh Cages for Treatment of Degenerative Cervical Pathologies: A Literature Review , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[10]  F. Boop,et al.  Retrospective single-surgeon study of 1123 consecutive cases of anterior cervical discectomy and fusion: a comparison of clinical outcome parameters, complication rates, and costs between outpatient and inpatient surgery groups, with a literature review. , 2018, Journal of neurosurgery. Spine.

[11]  Huiyong Shen,et al.  Influences of different lower cervical bone graft heights on the size of the intervertebral foramen: multiple planar dynamic measurements with laser scanning , 2018, Lasers in Medical Science.

[12]  C. Ames,et al.  Changes in foraminal area with anterior decompression versus keyhole foraminotomy in the cervical spine: a biomechanical investigation. , 2017, Journal of neurosurgery. Spine.

[13]  G. Giammalva,et al.  White cord syndrome after non-contiguous double-level anterior cervical decompression and fusion (ACDF): A “no reflow phenomenon”? , 2017 .

[14]  P. Liu,et al.  Resection or degeneration of uncovertebral joints altered the segmental kinematics and load-sharing pattern of subaxial cervical spine: A biomechanical investigation using a C2-T1 finite element model. , 2016, Journal of biomechanics.

[15]  S. Moon,et al.  Clinical Outcome and Changes of Foraminal Dimension in Patients With Foraminal Stenosis After ACDF , 2015, Journal of spinal disorders & techniques.

[16]  T. Ryken,et al.  Indications for anterior cervical decompression for the treatment of cervical degenerative radiculopathy. , 2009, Journal of neurosurgery. Spine.

[17]  R. Ergün,et al.  Early changes in the cervical foraminal area after anterior interbody fusion with polyetheretherketone (PEEK) cage containing synthetic bone particulate: a prospective study of 20 cases , 2006, Neurological research.

[18]  Manohar M. Panjabi,et al.  Dynamic Intervertebral Foramen Narrowing During Simulated Rear Impact , 2006, Spine.

[19]  Jung-Tung Liu,et al.  Preliminary experience using a polyetheretherketone (PEEK) cage in the treatment of cervical disc disease. , 2002, Neurosurgery.

[20]  R. Bartels,et al.  Height of cervical foramina after anterior discectomy and implantation of a carbon fiber cage. , 2001, Journal of neurosurgery.

[21]  S. Gill,et al.  Transpedicular approaches to cervical uncovertebral osteophytes causing radiculopathy. , 2000, Journal of neurosurgery.

[22]  T. Albert,et al.  An in vivo analysis of the dimensional changes of the neuroforamen after anterior cervical diskectomy and fusion: a radiologic investigation. , 1997, Journal of spinal disorders.

[23]  R. Yeasting,et al.  Evaluation of Cervical Posterior Lateral Mass Screw Placement by Oblique Radiographs , 1996, Spine.

[24]  Jung U. Yoo,et al.  The Role of Distraction in Improving the Space Available for the Cord in Cervical Spondylosis , 1995, Spine.

[25]  W Caspar,et al.  Anterior cervical fusion and Caspar plate stabilization for cervical trauma. , 1989, Neurosurgery.

[26]  J. Marniemi,et al.  Radiochemical assay of glutathione S-epoxide transferase and its enhancement by phenobarbital in rat liver in vivo. , 1975, Biochemical pharmacology.

[27]  R. Robinson,et al.  The treatment of certain cervical-spine disorders by anterior removal of the intervertebral disc and interbody fusion. , 1958, The Journal of bone and joint surgery. American volume.

[28]  S. Garfin,et al.  Cervical Radiculopathy. , 1996, The Orthopedic clinics of North America.