Young age is associated with increased rates of residual and recurrent paediatric differentiated thyroid carcinoma

Differentiated thyroid carcinoma is rare in young children. There are conflicting data as to whether disease in this age group differs from that in adolescents and specifically, if it is more aggressive. Current practice guidelines do not differentiate treatment between these groups, but speculate that differences may exist. We sought to compare clinical features, treatment and outcomes between children (<12 years) and adolescents (12‐18 years) with thyroid nodules and thyroid malignancy over a 20‐year period.

[1]  M. Luster,et al.  Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer , 2018, Pediatrics.

[2]  M. Tucker,et al.  Thyroid Cancer after Childhood Exposure to External Radiation: An Updated Pooled Analysis of 12 Studies , 2016, Radiation Research.

[3]  M. Phillip,et al.  Pediatric Thyroid Cancer: Postoperative Classifications and Response to Initial Therapy as Prognostic Factors. , 2016, The Journal of clinical endocrinology and metabolism.

[4]  J. Lew,et al.  Surgically Treated Pediatric Nonpapillary Thyroid Carcinoma , 2015, European Journal of Pediatric Surgery.

[5]  M. Zimmermann,et al.  Iodine intake as a risk factor for thyroid cancer: a comprehensive review of animal and human studies , 2015, Thyroid Research.

[6]  Benjamin D. Smith,et al.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. , 2014, Cancer research.

[7]  P. Larsen,et al.  A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. , 2013, The Journal of clinical endocrinology and metabolism.

[8]  I. Asli,et al.  Differentiated thyroid carcinoma: comparison of histopathologic characteristics, clinical course, and outcome between young children and adolescents , 2013, Medical Oncology.

[9]  R. Tuttle,et al.  Suspicious cervical lymph nodes detected after thyroidectomy for papillary thyroid cancer usually remain stable over years in properly selected patients. , 2012, The Journal of clinical endocrinology and metabolism.

[10]  S. Rivkees,et al.  The treatment of differentiated thyroid cancer in children: emphasis on surgical approach and radioactive iodine therapy. , 2011, Endocrine reviews.

[11]  M. Stevens,et al.  Risk of thyroid cancer in survivors of childhood cancer: Results from the British Childhood Cancer Survivor Study , 2009, International journal of cancer.

[12]  L. Koniaris,et al.  Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients. , 2009, The Journal of surgical research.

[13]  M. Phillip,et al.  Differentiated thyroid carcinoma in pediatric patients: comparison of presentation and course between pre-pubertal children and adolescents. , 2009, The Journal of pediatrics.

[14]  S. Rivkees,et al.  Clinical and economic outcomes of thyroid and parathyroid surgery in children. , 2008, The Journal of clinical endocrinology and metabolism.

[15]  M. Niedziela,et al.  A prospective study of thyroid nodular disease in children and adolescents in western Poland from 1996 to 2000 and the incidence of thyroid carcinoma relative to iodine deficiency and the Chernobyl disaster , 2004, Pediatric blood & cancer.

[16]  G. Blair,et al.  Age is the major determinant of recurrence in pediatric differentiated thyroid carcinoma. , 2000, Medical and pediatric oncology.

[17]  G. Reaman,et al.  Cancer in adolescents and young adults , 1993, Cancer.

[18]  MS David F. Schneider MD,et al.  Impact of Lymph Node Ratio on Survival in Papillary Thyroid Cancer , 2012, Annals of Surgical Oncology.

[19]  M. Charron,et al.  Evidence-based Review of Treatment and Follow up of Pediatric Patients with Differentiated Thyroid Carcinoma , 2006, Journal of pediatric endocrinology & metabolism : JPEM.

[20]  A. Bleyer,et al.  Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000. , 2006 .