Reactions of 4-substituted tetrafluoropyridine derivatives with sulfur nucleophiles: SNAr and annelation processes

[1]  J. Howard,et al.  Annelation of perfluorinated heteroaromatic systems by 1,3-dicarbonyl derivatives , 2010 .

[2]  J. Howard,et al.  Annelation reactions of pentafluorobenzonitrile , 2010 .

[3]  J. Howard,et al.  Dipyrido[1,2-a;3′,4′-d]imidazole systems , 2010 .

[4]  J. Howard,et al.  N-Functionalised polyfluoropyridazin-3(2H)-one derivatives , 2009 .

[5]  J. Howard,et al.  Polysubstituted pyridazinones from sequential nucleophilic substitution reactions of tetrafluoropyridazine. , 2009, The Journal of organic chemistry.

[6]  J. Howard,et al.  Synthesis of tetrahydropyrido[2,3- b ]pyrazine scaffolds from 2,3,5,6-tetrafluoropyridine derivatives , 2007 .

[7]  A. Kranjc,et al.  Recent advances in the discovery of tissue factor/factor VIIa inhibitors and dual inhibitors of factor VIIa/factor Xa. , 2005, Current pharmaceutical design.

[8]  J. Howard,et al.  Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds from 4-phenylsulfonyl tetrafluoropyridine. , 2005, The Journal of organic chemistry.

[9]  R. Chambers,et al.  Elemental fluorine. Part 18. Selective direct fluorination of 1,3-ketoesters and 1,3-diketones using gas/liquid microreactor technology. , 2005, Lab on a chip.

[10]  J. Howard,et al.  Tetrahydropyrido[3,4-b]pyrazine scaffolds from pentafluoropyridine. , 2005, The Journal of organic chemistry.

[11]  Takashi Okazoe,et al.  Versatile Gas/Liquid Microreactors for Industry , 2005 .

[12]  R. Chambers,et al.  Elemental fluorine. Part 16. Versatile thin-film gas-liquid multi-channel microreactors for effective scale-out. , 2005, Lab on a chip.

[13]  J. Howard,et al.  Polyhalogenoheterocyclic compounds: Part 51. [1] Macrocycles from 4-alkoxy-tetrafluoropyridine derivatives , 2004 .

[14]  J. Howard,et al.  Polyhalogenated heterocyclic compounds. Macrocycles from perfluoro-4-isopropylpyridine. , 2003, Organic & biomolecular chemistry.

[15]  R. Wolf,et al.  SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors. , 2002, Bioorganic & medicinal chemistry letters.

[16]  K. Eagen,et al.  Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines. , 2002, Bioorganic & medicinal chemistry.

[17]  J. Howard,et al.  Polyhalogenated heterocyclic compounds. Part 47. Syntheses of multi-substituted pyridine derivatives from pentafluoropyridine , 2001 .

[18]  G. Brooke.  The preparation and properties of polyfluoro aromatic and heteroaromatic compounds , 1997 .

[19]  J. Elguero,et al.  Aromatic propellenes. Synthesis, X-Ray structures and conformational study of polypyrazolylpyridines , 1996 .

[20]  M. J. Silvester.  Recent advances in fluoroheterocyclic chemistry , 1994 .

[21]  K Fujikawa,et al.  The coagulation cascade: initiation, maintenance, and regulation. , 1991, Biochemistry.

[22]  K. Tsuda,et al.  Nucleophilic substitution of halopyridines by benzenethiolate anion via a radical chain mechanism , 1984 .

[23]  R. Chambers,et al.  Fluorine in organic chemistry , 1973 .