Induction of premature senescence and a less-fibrogenic phenotype by programmed cell death 4 knockdown in the human hepatic stellate cell line Lieming Xu-2

[1]  L. Niedernhofer,et al.  Recent advances in the discovery of senolytics , 2021, Mechanisms of Ageing and Development.

[2]  See-Hyoung Park,et al.  Induction of cell cycle arrest and apoptosis by tomentosin in hepatocellular carcinoma HepG2 and Huh7 cells , 2020, Human & experimental toxicology.

[3]  Yong Liu,et al.  Osteopontin Upregulates Col IV Expression by Repressing miR-29a in Human Retinal Capillary Endothelial Cells , 2020, Molecular therapy. Nucleic acids.

[4]  D. Pinato,et al.  Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis , 2019, Scientific Reports.

[5]  Yingying Chen,et al.  Abnormal expression and mutation of the RBPJ gene may be involved in CD59− clonal proliferation in paroxysmal nocturnal hemoglobinuria , 2019, Experimental and therapeutic medicine.

[6]  Hirokazu Takahashi,et al.  PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression , 2017, Front. Oncol..

[7]  S. Friedman,et al.  Hepatic stellate cells as key target in liver fibrosis. , 2017, Advanced drug delivery reviews.

[8]  V. Soetikno,et al.  Alpha mangostin Inhibits Hepatic Stellate Cells Activation Through TGF-β/Smad and Akt Signaling Pathways: An in vitro Study in LX2 , 2017, Drug Research.

[9]  K. Miyazawa,et al.  Snail suppresses cellular senescence and promotes fibroblast‐led cancer cell invasion , 2017, FEBS open bio.

[10]  N. Colburn,et al.  Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma , 2017, Oncogene.

[11]  David M. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[12]  R. Tajhya,et al.  Detection of Matrix Metalloproteinases by Zymography. , 2017, Methods in molecular biology.

[13]  Dong Eun Kim,et al.  PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation , 2016, Oncotarget.

[14]  Dimitris Kletsas,et al.  Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing , 2016, Nature Cell Biology.

[15]  A. Lujambio.  To clear, or not to clear (senescent cells)? That is the question , 2016, BioEssays : news and reviews in molecular, cellular and developmental biology.

[16]  Emanuel,et al.  Protracted p53-independent stimulation of p21 fuels genomic instability by deregulating the replication licensing machinery , 2016 .

[17]  Dong Eun Kim,et al.  Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation , 2015, Nature Cell Biology.

[18]  S. Friedman,et al.  Pathobiology of liver fibrosis: a translational success story , 2015, Gut.

[19]  K. Iwaisako,et al.  Origin of myofibroblasts in the fibrotic liver in mice , 2014, Proceedings of the National Academy of Sciences.

[20]  N. Colburn,et al.  Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65. , 2014, Carcinogenesis.

[21]  H. Zhang,et al.  Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells. , 2014, Cellular signalling.

[22]  R. Ordoñez,et al.  Inhibition of matrix metalloproteinase‐9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells , 2014, Journal of pineal research.

[23]  A. Nakashima,et al.  Branched-Chain Amino Acids Enhance Premature Senescence through Mammalian Target of Rapamycin Complex I-Mediated Upregulation of p21 Protein , 2013, PloS one.

[24]  S. Friedman,et al.  Hepatic stellate cells and liver fibrosis. , 2013, Comprehensive Physiology.

[25]  Masahira Hattori,et al.  Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome , 2013, Nature.

[26]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[27]  Hsin-Sheng Yang,et al.  Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc. , 2012, Biochimica et biophysica acta.

[28]  Christopher K. Glass,et al.  Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis , 2012, Proceedings of the National Academy of Sciences.

[29]  K. Iwaisako,et al.  What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis , 2012, Journal of gastroenterology and hepatology.

[30]  K. Eto,et al.  Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA , 2011, Cell Death and Differentiation.

[31]  Hsin-Sheng Yang,et al.  AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation. , 2011, Genes & cancer.

[32]  D. Peeper,et al.  The essence of senescence. , 2010, Genes & development.

[33]  S. Lowe,et al.  Senescence of Activated Stellate Cells Limits Liver Fibrosis , 2008, Cell.

[34]  K. Klempnauer,et al.  siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression , 2008, Oncogene.

[35]  L. Chiriboga,et al.  Alterations in the expression of PDCD4 in ductal carcinoma of the breast. , 2007, Oncology reports.

[36]  Y. Narisawa,et al.  Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions , 2007, Experimental dermatology.

[37]  Chunhong Ma,et al.  Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma. , 2007, Oncology reports.

[38]  M. Böttger,et al.  Expression of decorin and collagens I and III in different layers of human skin in vivo: a laser capture microdissection study , 2007, Biogerontology.

[39]  Michele Pagano,et al.  S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth , 2006, Science.

[40]  H. Zhang,et al.  Involvement of programmed cell death 4 in transforming growth factor-β1-induced apoptosis in human hepatocellular carcinoma , 2006, Oncogene.

[41]  Kyuyoung Song,et al.  Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. , 2006, Oncology reports.

[42]  H. Zhang,et al.  [Expression of programmed cell death 4 and its clinicopathological significance in human pancreatic cancer]. , 2005, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.

[43]  S. Friedman,et al.  Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis , 2004, Gut.

[44]  K. Miyazaki,et al.  Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells , 2004, British Journal of Cancer.

[45]  Yoshinori Hasegawa,et al.  GADD34 induces p53 phosphorylation and p21/WAF1 transcription , 2003, Journal of cellular biochemistry.

[46]  Iver Petersen,et al.  Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis , 2003, The Journal of pathology.

[47]  Anindya Dutta,et al.  A p53-dependent checkpoint pathway prevents rereplication. , 2003, Molecular cell.

[48]  D. Brenner,et al.  Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype , 2003, Hepatology.

[49]  M. Arthur,et al.  Extracellular Matrix Degradation and the Role of Hepatic Stellate Cells , 2001, Seminars in liver disease.

[50]  G. Peters,et al.  Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts , 1998, Current Biology.

[51]  Wenyi Wei,et al.  Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. , 1997, Science.

[52]  C. Brinckerhoff,et al.  The AP-1 site and MMP gene regulation: what is all the fuss about? , 1997, Matrix biology : journal of the International Society for Matrix Biology.

[53]  T. Honjo,et al.  Recognition sequence of a highly conserved DNA binding protein RBP-Jx , 1994 .

[54]  T. Honjo,et al.  Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. , 1994, Nucleic acids research.

[55]  Axel M. Gressner,et al.  Tumor necrosis factor alpha (TNFα) and transforming growth factor β1 (TGFβ1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts , 1993 .

[56]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[57]  D. Schuppan,et al.  Structure of the Extracellular Matrix in Normal and Fibrotic Liver: Collagens and Glycoproteins , 1990, Seminars in liver disease.

[58]  T. Veit,et al.  Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells , 1990, Virchows Archiv. B, Cell pathology including molecular pathology.

[59]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.