Conformational and structural considerations in oxytocin-receptor binding and biological activity.

[1]  M. Lebl,et al.  Analogs of oxytocin containing a pseudopeptide Leu-Gly bond of cis and trans configuration. , 2009, International journal of peptide and protein research.

[2]  L. Kinter,et al.  Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines. , 1989, Journal of medicinal chemistry.

[3]  V. Hruby,et al.  Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors. , 1988, Journal of medicinal chemistry.

[4]  V. Hruby,et al.  Weak oxytocin agonist converted to highly potent oxytocin antagonist through bicyclization , 1988 .

[5]  L. Kinter,et al.  Potent vasopressin antagonists modified at the carboxy-terminal tripeptide tail. , 1987, Journal of medicinal chemistry.

[6]  J. Hempel Chapter 5 – The Conformation of Neurohypophyseal Hormones , 1987 .

[7]  M. Lebl,et al.  CRC handbook of neurohypophyseal hormone analogs , 1987 .

[8]  M. Manning,et al.  No requirement of cyclic conformation of antagonists in binding to vasopressin receptors , 1987, Nature.

[9]  G. Gessa,et al.  Oxytocin: an extremely potent inducer of penile erection and yawning in male rats. , 1986, European journal of pharmacology.

[10]  I. L. Schwartz,et al.  Antidiuretic and pressor activities of vasopressin analogs with L-alaninamide and D-alaninamide substitutions at position 9. , 2009, International journal of peptide and protein research.

[11]  M. Manning,et al.  Carboxy terminus of vasopressin required for activity but not binding , 1984, Nature.

[12]  J. Glass,et al.  Studies of Hydrogen Bonding in Relation to Oxytocin Activity , 1983 .

[13]  G. Kovacs,et al.  Oxytocin is a precursor of potent behaviourally active neuropeptides. , 1983, European journal of pharmacology.

[14]  V. Hruby,et al.  Conformational study of the potent peptide hormone antagonist [1-penicillamine,2-leucine]oxytocin in aqueous solution. , 1981, Biochemistry.

[15]  M. Sofroniew,et al.  Evidence for a direct projection from oxytocin and vasopressin neurons in the hypothalamic paraventricular nucleus to the medulla oblongata: Immunohistochemical visualization of both the horseradish peroxidase transported and the peptide produced by the same neurons , 1981, Neuroscience Letters.

[16]  P. Cordopatis,et al.  Effect of changing the COOH-terminal amide group present in the hydrophilic cluster of oxytocin to dimethylamide. , 1980, Journal of medicinal chemistry.

[17]  G. Berntson,et al.  Antinociceptive effects of intraventricular or systemic administration of vasopressin in the rat. , 1980, Life sciences.

[18]  R. Walter,et al.  Synthesis and biological activities of arginine-vasopressin analogues designed from a conformation-activity approach. , 1979, Journal of medicinal chemistry.

[19]  P. Walter Indentification of sites in oxytocin involved in uterine receptor recognition and activation. , 1977, Federation proceedings.

[20]  V. Hruby,et al.  Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. Manning,et al.  Synthesis and some pharmacological properties of deamino(4-threonine,8-D-arginine)vasopressin and deamino(8-D-arginine)vasopressin, highly potent and specific antidiuretic peptides, and (8-D-arginine)vasopressin and deamino-arginine-vasopressin. , 1976, Journal of medicinal chemistry.

[22]  R. Walter,et al.  Conformational studies on arginine vasopressin and arginine vasotocin by proton magnetic resonance spectroscopy. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Manning,et al.  Structural changes in the arginine vasopressin molecule that enhance antidiuretic activity and specificity. , 1974, Endocrinology.

[24]  F. Šorm,et al.  Synthesis and some biological activities of analogues of deamino-vasopressin with the disulphide bridge altered to a thioether bridge , 1974 .

[25]  E. Schillinger,et al.  Structure activity relationship of the insulin-like effects of the neurohypophysial peptide hormones. , 1972, European journal of biochemistry.

[26]  L. B. Flexner,et al.  Effect of corticotropin and desglycinamide 9 -lysine vasopressin on suppression of memory by puromycin. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. W. Roberts,et al.  THE SYNTHESIS OF AN OCTAPEPTIDE AMIDE WITH THE HORMONAL ACTIVITY OF OXYTOCIN , 1953 .