One-pot Efficient Synthesis of Cbz-protected β-Amino Ketones: Three-component Coupling of Aldehydes, Ketones, and Benzyl Carbamate

An efficient one-pot three-component reactions of aldehydes, ketones, and benzyl carbamate in the presence of a catalytic amount of (bromodimethyl)sulfonium bromide have been accomplished in short reaction time to afford the corresponding Cbz-protected ;8-amino ketones in high yields and good diastereoselectivity.

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