Wnt pathway: a hallmark of drug discovery challenge.

[1]  R. Nusse,et al.  Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities , 2017, Cell.

[2]  S. Manicassamy,et al.  Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer , 2016, Front. Immunol..

[3]  K. Bhalla,et al.  Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors. , 2015, Journal of medicinal chemistry.

[4]  K. Bhalla,et al.  Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells , 2014, Leukemia.

[5]  R. Nusse,et al.  An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control , 2014, Science.

[6]  Michael Kahn,et al.  Can we safely target the WNT pathway? , 2014, Nature Reviews Drug Discovery.

[7]  W. Sellers,et al.  Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 , 2013, Proceedings of the National Academy of Sciences.

[8]  S. Krauss,et al.  Tankyrases as drug targets , 2013, The FEBS journal.

[9]  T. Grossmann,et al.  Direct targeting of β-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling. , 2013, Bioorganic & medicinal chemistry.

[10]  C. Niehrs.  The complex world of WNT receptor signalling , 2012, Nature Reviews Molecular Cell Biology.

[11]  B. R. Bowman,et al.  Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin , 2012, Proceedings of the National Academy of Sciences.

[12]  F. E. Bertrand,et al.  Developmental pathways in colon cancer , 2012, Cell cycle.

[13]  N. Lin,et al.  Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. , 2012, Biochemistry.

[14]  R. Dasgupta,et al.  An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway , 2011, Proceedings of the National Academy of Sciences.

[15]  C. Nguyên,et al.  Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis , 2010, Proceedings of the National Academy of Sciences.

[16]  J. Freese,et al.  Wnt signaling in development and disease , 2010, Neurobiology of Disease.

[17]  Xi He,et al.  Wnt/beta-catenin signaling: components, mechanisms, and diseases. , 2009, Developmental cell.

[18]  Jie J. Zheng,et al.  Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled* , 2009, The Journal of Biological Chemistry.

[19]  Frank Petersen,et al.  Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex , 2004 .

[20]  Jonas Wittwer,et al.  Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5 , 2003, The EMBO journal.