Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

[1]  T. Dinan,et al.  Microbiota and neurodevelopmental windows: implications for brain disorders. , 2014, Trends in molecular medicine.

[2]  T. Dinan,et al.  Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour , 2014, Acta paediatrica.

[3]  M. Sekelja,et al.  Correlation between the human fecal microbiota and depression , 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[4]  W. D. de Vos,et al.  The first 1000 cultured species of the human gastrointestinal microbiota , 2014, FEMS microbiology reviews.

[5]  J. Terrón,et al.  Novel insights into the potential involvement of 5-HT7 receptors in endocrine dysregulation in stress-related disorders , 2014, Reviews in the neurosciences.

[6]  T. Dinan,et al.  Selective influence of host microbiota on cAMP‐mediated ion transport in mouse colon , 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[7]  S. Rabot,et al.  Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats , 2014, Psychoneuroendocrinology.

[8]  T. Kusaka,et al.  Prolonged maternal separation disturbs the serotonergic system during early brain development , 2014, International Journal of Developmental Neuroscience.

[9]  F. Jin,et al.  Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat , 2014, Science China Life Sciences.

[10]  M. León‐Olea,et al.  Age differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphe , 2014, Behavioral and Brain Functions.

[11]  M. Bellini,et al.  Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome , 2014, Techniques in Coloproctology.

[12]  Shantanu H. Joshi,et al.  Irritable bowel syndrome in female patients is associated with alterations in structural brain networks , 2014, PAIN®.

[13]  M. Saffrey.  Aging of the mammalian gastrointestinal tract: a complex organ system , 2013, AGE.

[14]  Lawrence A. David,et al.  Diet rapidly and reproducibly alters the human gut microbiome , 2013, Nature.

[15]  J. M. Rodríguez,et al.  Antibiotic resistance, virulence determinants and production of biogenic amines among enterococci from ovine, feline, canine, porcine and human milk , 2013, BMC Microbiology.

[16]  S. Fukudo.  Stress and visceral pain: Focusing on irritable bowel syndrome , 2013, PAIN®.

[17]  W. Kaye,et al.  The ingestion of different dietary proteins by humans induces large changes in the plasma tryptophan ratio, a predictor of brain tryptophan uptake and serotonin synthesis. , 2013, Clinical nutrition.

[18]  John F. Cryan,et al.  Psychobiotics: A Novel Class of Psychotropic , 2013, Biological Psychiatry.

[19]  M. Saffrey.  Cellular changes in the enteric nervous system during ageing. , 2013, Developmental biology.

[20]  A. Carvalho,et al.  Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration. , 2013, Journal of psychiatric research.

[21]  G. Pacini,et al.  Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation , 2013, Molecular Psychiatry.

[22]  C. Ohland,et al.  Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome , 2013, Psychoneuroendocrinology.

[23]  S. Young,et al.  Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects. , 2013, Journal of psychiatry & neuroscience : JPN.

[24]  T. Dinan,et al.  Melancholic microbes: a link between gut microbiota and depression? , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[25]  J. Groeger,et al.  Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory , 2013, Psychological Medicine.

[26]  D. Spengler,et al.  Epigenetic Risk Factors in PTSD and Depression , 2013, Front. Psychiatry.

[27]  J. Hoffman,et al.  Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets , 2013, Nature Reviews Gastroenterology &Hepatology.

[28]  D. Gibbons,et al.  The gut mucosal immune system in the neonatal period , 2013, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[29]  P. Bercik,et al.  Altered colonic function and microbiota profile in a mouse model of chronic depression , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[30]  P. Scully,et al.  The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner , 2013, Molecular Psychiatry.

[31]  B. Naliboff,et al.  Consumption of fermented milk product with probiotic modulates brain activity. , 2013, Gastroenterology.

[32]  L. Desbonnet,et al.  Microbiota is essential for social development in the mouse , 2013, Molecular Psychiatry.

[33]  R. Heuckeroth,et al.  Enteric nervous system development: migration, differentiation, and disease , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[34]  R. Schwarcz,et al.  Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. , 2013, Biochemical pharmacology.

[35]  J. Neu,et al.  Effect of intestinal microbial ecology on the developing brain. , 2013, JAMA pediatrics.

[36]  Christopher L. Gardner,et al.  Lactobacillus johnsonii inhibits indoleamine 2,3‐dioxygenase and alters tryptophan metabolite levels in BioBreeding rats , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  M. Sears,et al.  Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months , 2013, Canadian Medical Association Journal.

[38]  F. Bäckhed,et al.  The gut microbiota — masters of host development and physiology , 2013, Nature Reviews Microbiology.

[39]  J. Neu,et al.  Gastrointestinal function development and microbiota , 2013, Italian Journal of Pediatrics.

[40]  K. Young,et al.  Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan. , 2013, Microbiology.

[41]  M. Gershon.  5-Hydroxytryptamine (serotonin) in the gastrointestinal tract , 2013, Current opinion in endocrinology, diabetes, and obesity.

[42]  S. Wood,et al.  Serotonin: from top to bottom , 2013, Biogerontology.

[43]  E. Dempsey,et al.  Microbiota diversity and stability of the preterm neonatal ileum and colon of two infants , 2013, MicrobiologyOpen.

[44]  G. Oxenkrug,et al.  Kynurenic Acid in the Digestive System—New Facts, New Challenges , 2013, International journal of tryptophan research : IJTR.

[45]  J. Toldi,et al.  Kynurenines in the CNS: recent advances and new questions , 2012, Nature Reviews Drug Discovery.

[46]  Andrew C. Terentis,et al.  Human Indoleamine 2,3-Dioxygenase Is a Catalyst of Physiological Heme Peroxidase Reactions , 2012, The Journal of Biological Chemistry.

[47]  M. Kleerebezem,et al.  The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. , 2012, Beneficial microbes.

[48]  S. Kennedy,et al.  Novel therapeutic targets in depression: Minocycline as a candidate treatment , 2012, Behavioural Brain Research.

[49]  J. Fernstrom.  Effects and side effects associated with the non-nutritional use of tryptophan by humans. , 2012, The Journal of nutrition.

[50]  Alexander C. Ford.  Acupuncture for irritable bowel syndrome. , 2012, Gastroenterology.

[51]  J. Mclaughlin,et al.  Ageing and the gut , 2012, Proceedings of the Nutrition Society.

[52]  H. Mushiake,et al.  Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling. , 2012, Gastroenterology.

[53]  F. Özoğul,et al.  The Function of Lactic Acid Bacteria on Biogenic Amines Production by Food-Borne Pathogens in Arginine Decarboxylase Broth , 2012 .

[54]  M. Surette,et al.  The interplay between the intestinal microbiota and the brain , 2012, Nature Reviews Microbiology.

[55]  T. Pan,et al.  The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits , 2012, Applied Microbiology and Biotechnology.

[56]  T. Dinan,et al.  Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour , 2012, Nature Reviews Neuroscience.

[57]  J. Gordon,et al.  Diversity, stability and resilience of the human gut microbiota , 2012, Nature.

[58]  George M. Weinstock,et al.  Genomic approaches to studying the human microbiota , 2012, Nature.

[59]  T. Dinan,et al.  Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology , 2012, Psychoneuroendocrinology.

[60]  D. Macfabe,et al.  Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders , 2012, Microbial ecology in health and disease.

[61]  D. Relman.  The human microbiome: ecosystem resilience and health. , 2012, Nutrition reviews.

[62]  O. Craig,et al.  Irritable bowel syndrome; update on pathophysiology and management. , 2012, The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.

[63]  P. Klivényi,et al.  Manipulating kynurenic acid levels in the brain - on the edge between neuroprotection and cognitive dysfunction. , 2012, Current topics in medicinal chemistry.

[64]  D. Sinderen,et al.  Gut microbiota composition correlates with diet and health in the elderly , 2012, Nature.

[65]  S. Milani,et al.  Altered neuro-endocrine–immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model , 2012, Journal of Gastroenterology.

[66]  R. Knight,et al.  Spatial and temporal variability of the human microbiota. , 2012, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[67]  R. Schwarcz,et al.  Kynurenines in the mammalian brain: when physiology meets pathology , 2012, Nature Reviews Neuroscience.

[68]  M. Furuya,et al.  Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[69]  Katherine H. Huang,et al.  A framework for human microbiome research , 2012, Nature.

[70]  S. Collins,et al.  Microbes and the gut‐brain axis , 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[71]  M. Gershon.  The play is still being written on opening day: postnatal maturation of enteric neurons may provide an opening for early life mischief , 2012, The Journal of physiology.

[72]  T. Dinan,et al.  A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome , 2012, Front. Pharmacol..

[73]  T. Stone,et al.  Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection , 2012, The FEBS journal.

[74]  Norman R. Saunders,et al.  Barrier Mechanisms in the Developing Brain , 2012, Front. Pharmacol..

[75]  J. Clemente,et al.  Human gut microbiome viewed across age and geography , 2012, Nature.

[76]  J. Homberg,et al.  The reciprocal interaction between serotonin and social behaviour , 2012, Neuroscience & Biobehavioral Reviews.

[77]  T. Dinan,et al.  Review article: probiotics for the treatment of irritable bowel syndrome – focus on lactic acid bacteria , 2012, Alimentary pharmacology & therapeutics.

[78]  J. Groeger,et al.  Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome , 2012, Neuroscience & Biobehavioral Reviews.

[79]  J. Homberg.  Serotonin and decision making processes , 2012, Neuroscience & Biobehavioral Reviews.

[80]  B. Berger,et al.  The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[81]  P. Levitt,et al.  Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain , 2011, Neuroscience.

[82]  P. Gaspar,et al.  Development of raphe serotonin neurons from specification to guidance , 2011, The European journal of neuroscience.

[83]  N. Floc’h,et al.  Tryptophan metabolism, from nutrition to potential therapeutic applications , 2011, Amino Acids.

[84]  John F. Cryan,et al.  Brain–Gut–Microbe Communication in Health and Disease , 2011, Front. Physio..

[85]  E. Fox,et al.  Development of the vagal innervation of the gut: steering the wandering nerve , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[86]  K. Kurz,et al.  Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells. , 2011, Transplant immunology.

[87]  T. Dinan,et al.  Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve , 2011, Proceedings of the National Academy of Sciences.

[88]  William D. Chey,et al.  Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome , 2011, Gut and liver.

[89]  Mark Lyte,et al.  Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics , 2011, BioEssays : news and reviews in molecular, cellular and developmental biology.

[90]  K. McCoy,et al.  The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. , 2011, Gastroenterology.

[91]  Emeran A. Mayer,et al.  Gut feelings: the emerging biology of gut–brain communication , 2011, Nature Reviews Neuroscience.

[92]  F. Ponti,et al.  Intestinal Serotonin Release, Sensory Neuron Activation, and Abdominal Pain in Irritable Bowel Syndrome , 2011, The American Journal of Gastroenterology.

[93]  M. Bracken,et al.  Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review , 2011, Pediatrics.

[94]  W. Walker,et al.  The Role of Microbes in Developmental Immunologic Programming , 2011, Pediatric Research.

[95]  G. Pezzoli,et al.  Use of probiotics for the treatment of constipation in Parkinson's disease patients. , 2011, Minerva gastroenterologica e dietologica.

[96]  G. Barbara,et al.  Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome , 2011, Current gastroenterology reports.

[97]  T. Dinan,et al.  Altered peripheral toll‐like receptor responses in the irritable bowel syndrome , 2011, Alimentary pharmacology & therapeutics.

[98]  B. Leonard,et al.  The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[99]  J. Foster,et al.  Reduced anxiety‐like behavior and central neurochemical change in germ‐free mice , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[100]  Michael Camilleri.  LX‐1031, a tryptophan 5‐hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[101]  D. Drossman,et al.  Centrally acting therapies for irritable bowel syndrome. , 2011, Gastroenterology clinics of North America.

[102]  J. Cryan,et al.  The microbiome‐gut‐brain axis: from bowel to behavior , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[103]  John F. Cryan,et al.  Maternal separation as a model of brain–gut axis dysfunction , 2011, Psychopharmacology.

[104]  G. Swain,et al.  Postnatal development of the serotonin signaling system in the mucosa of the guinea pig ileum , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[105]  A. Fanning,et al.  Differential Expression of Toll-Like Receptors in Patients With Irritable Bowel Syndrome , 2011, The American Journal of Gastroenterology.

[106]  H. Forssberg,et al.  Normal gut microbiota modulates brain development and behavior , 2011, Proceedings of the National Academy of Sciences.

[107]  E. Mayer,et al.  The brain-gut axis in abdominal pain syndromes. , 2011, Annual review of medicine.

[108]  W. Jackson,et al.  Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. , 2010, Gastroenterology.

[109]  C. Bernstein,et al.  Association Between the Use of Antibiotics in the First Year of Life and Pediatric Inflammatory Bowel Disease , 2010, The American Journal of Gastroenterology.

[110]  L. Desbonnet,et al.  Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression , 2010, Neuroscience.

[111]  M. Messaoudi,et al.  Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects , 2010, British Journal of Nutrition.

[112]  G. MacQueen,et al.  Bacterial infection causes stress-induced memory dysfunction in mice , 2010, Gut.

[113]  D. Relman,et al.  Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation , 2010, Proceedings of the National Academy of Sciences.

[114]  T. Dinan,et al.  The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat , 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[115]  C. Lebrilla,et al.  Human milk glycobiome and its impact on the infant gastrointestinal microbiota , 2010, Proceedings of the National Academy of Sciences.

[116]  W. Khan,et al.  Gut hormones: emerging role in immune activation and inflammation , 2010, Clinical and experimental immunology.

[117]  Jintae Lee,et al.  Indole as an intercellular signal in microbial communities. , 2010, FEMS microbiology reviews.

[118]  Marcus J. Claesson,et al.  Composition, variability, and temporal stability of the intestinal microbiota of the elderly , 2010, Proceedings of the National Academy of Sciences.

[119]  R. Knight,et al.  Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns , 2010, Proceedings of the National Academy of Sciences.

[120]  M. Ugrumov,et al.  Developing Brain as an Endocrine Organ: A Paradoxical Reality , 2010, Neurochemical Research.

[121]  J. Furness,et al.  A selective, high affinity 5‐HT2B receptor antagonist inhibits visceral hypersensitivity in rats , 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[122]  T. Dinan,et al.  5‐HT2B receptors modulate visceral hypersensitivity in a stress‐sensitive animal model of brain‐gut axis dysfunction , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[123]  T. Dinan,et al.  Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome , 2009, PloS one.

[124]  J. Mallet,et al.  Serotonin has a key role in pathogenesis of experimental colitis. , 2009, Gastroenterology.

[125]  R. Dantzer,et al.  CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression , 2009, Molecular Psychiatry.

[126]  T. Dinan,et al.  Irritable bowel syndrome: towards biomarker identification. , 2009, Trends in molecular medicine.

[127]  N. Yurina,et al.  The impact of melaphene on the expression of chloroplastic chaperone protein HSP70B and photosynthetic pigments in cells of Chlamydomonas reinhardtii , 2009, Applied Biochemistry and Microbiology.

[128]  V. A. Shishov,et al.  Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12 , 2009, Applied Biochemistry and Microbiology.

[129]  P. Turnbaugh,et al.  The core gut microbiome, energy balance and obesity , 2009, The Journal of physiology.

[130]  R. Hen,et al.  5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice , 2009, The Journal of Neuroscience.

[131]  B. P. Brennan,et al.  Duloxetine in the treatment of irritable bowel syndrome: an open‐label pilot study , 2009, Human psychopharmacology.

[132]  B. McEwen,et al.  Effects of stress throughout the lifespan on the brain, behaviour and cognition , 2009, Nature Reviews Neuroscience.

[133]  R. Dantzer,et al.  Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice , 2009, Molecular Psychiatry.

[134]  E. Mayer,et al.  Principles and clinical implications of the brain–gut–enteric microbiota axis , 2009, Nature Reviews Gastroenterology &Hepatology.

[135]  A. Mozzarelli,et al.  Tryptophan synthase: a mine for enzymologists , 2009, Cellular and Molecular Life Sciences.

[136]  B. Brew,et al.  Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons , 2009, Neurotoxicity Research.

[137]  P. Klodt,et al.  Development of central and peripheral serotonin-producing systems in rats in ontogenesis , 2009, Journal of Evolutionary Biochemistry and Physiology.

[138]  B. Roth,et al.  The expanded biology of serotonin. , 2009, Annual review of medicine.

[139]  S. Dowd,et al.  Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria , 2009, Physiology & Behavior.

[140]  W. R. Wikoff,et al.  Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites , 2009, Proceedings of the National Academy of Sciences.

[141]  V. Pachnis,et al.  Development of the enteric nervous system: bringing together cells, signals and genes , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[142]  P. Scully,et al.  Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses , 2009, Biological Psychiatry.

[143]  M. Camilleri.  Serotonin in the gastrointestinal tract , 2009, Current opinion in endocrinology, diabetes, and obesity.

[144]  Gerard Clarke,et al.  Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort , 2009, BMC gastroenterology.

[145]  R. Wall,et al.  Role of Gut Microbiota in Early Infant Development , 2009, Clinical medicine. Pediatrics.

[146]  L. Desbonnet,et al.  The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. , 2008, Journal of psychiatric research.

[147]  P. Scully,et al.  Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon‐gamma, severity of symptoms and psychiatric co‐morbidity , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[148]  P. Moayyedi,et al.  Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis , 2008, Gut.

[149]  R. Spiller.  Serotonin and GI clinical disorders , 2008, Neuropharmacology.

[150]  B. Roe,et al.  A core gut microbiome in obese and lean twins , 2008, Nature.

[151]  H. Kokki,et al.  Serotonin and dopamine transporter binding in children with autism determined by SPECT , 2008, Developmental medicine and child neurology.

[152]  S. Gwaltney-Brant,et al.  Serotonin: a review. , 2008, Journal of veterinary pharmacology and therapeutics.

[153]  T. Dinan,et al.  Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[154]  R. Gaykema,et al.  Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior , 2008, Brain, Behavior, and Immunity.

[155]  M. Teixeira,et al.  Commensal microbiota is fundamental for the development of inflammatory pain , 2008, Proceedings of the National Academy of Sciences.

[156]  R. Spiller.  Serotonin, Inflammation, and IBS: Fitting the Jigsaw Together? , 2007, Journal of pediatric gastroenterology and nutrition.

[157]  L. Gandía,et al.  A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla , 2007, Acta physiologica.

[158]  C. Yanofsky,et al.  RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria. , 2007, RNA.

[159]  R. Spiller.  Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5‐HT signalling and metabolism in human disease , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[160]  M. Gershon,et al.  Serotonin and neuroprotection in functional bowel disorders , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[161]  J. Saavedra.  Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. , 2007, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[162]  M. Crowell,et al.  5-HT and the brain–gut axis: opportunities for pharmacologic intervention , 2007, Expert opinion on investigational drugs.

[163]  D. Bylund,et al.  Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults. , 2007, Biochemical pharmacology.

[164]  C. MacKenzie,et al.  Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines. , 2007, Current drug metabolism.

[165]  J. Changeux,et al.  Nicotine and serotonin in immune regulation and inflammatory processes: a perspective , 2007, Journal of leukocyte biology.

[166]  W. Leung,et al.  Effects of neonatal maternal separation on neurochemical and sensory response to colonic distension in a rat model of irritable bowel syndrome. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[167]  Kevin Lee,et al.  5-HT in the enteric nervous system: gut function and neuropharmacology , 2007, Trends in Neurosciences.

[168]  R. Spiller,et al.  Mechanisms of hypersensitivity in IBS and functional disorders , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[169]  N. Talley,et al.  Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[170]  B. Rollins,et al.  Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[171]  R. Gaykema,et al.  Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium , 2006, Physiology & Behavior.

[172]  H. Smidt,et al.  Influence of the gastrointestinal microbiota on development of the immune system in young animals. , 2006, Current issues in intestinal microbiology.

[173]  P. A. van den Brandt,et al.  Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy , 2006, Pediatrics.

[174]  D. Nutt,et al.  Tryptophan metabolism in the central nervous system: medical implications , 2006, Expert Reviews in Molecular Medicine.

[175]  W. MacNaughton,et al.  Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon , 2006, Cellular microbiology.

[176]  L. Lynd,et al.  Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis. , 2006, Chest.

[177]  M. Fernstrom,et al.  Exercise, serum free tryptophan, and central fatigue. , 2006, The Journal of nutrition.

[178]  R. Spiller,et al.  Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction , 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[179]  W. Jackson,et al.  Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice , 2005, Gut.

[180]  R. Corinaldesi,et al.  A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation , 2005, Gut.

[181]  D. Nutt,et al.  Acute Tryptophan Depletion. Part I: Rationale and Methodology , 2005, The Australian and New Zealand journal of psychiatry.

[182]  D. Nutt,et al.  Acute Tryptophan Depletion. Part II: Clinical Effects and Implications , 2005 .

[183]  D. Fuchs,et al.  Aspirin down‐regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro , 2005, Clinical and experimental immunology.

[184]  F. Shanahan,et al.  Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. , 2005, Gastroenterology.

[185]  Vikram Bhatia,et al.  Stress and the gastrointestinal tract , 2005, Journal of gastroenterology and hepatology.

[186]  J. Mikkelsen,et al.  Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain , 2005, Neuropharmacology.

[187]  Rie Suzuki,et al.  Bad news from the brain: descending 5-HT pathways that control spinal pain processing. , 2004, Trends in pharmacological sciences.

[188]  A. Majid,et al.  The Potential of Minocycline for Neuroprotection in Human Neurologic Disease , 2004, Clinical neuropharmacology.

[189]  W. Chey,et al.  Long-Term Safety and Efficacy of Alosetron in Women with Severe Diarrhea-Predominant Irritable Bowel Syndrome , 2004, The American Journal of Gastroenterology.

[190]  F. Özoğul,et al.  Production of biogenic amines by Morganella morganii, Klebsiella pneumoniae and Hafnia alvei using a rapid HPLC method , 2004 .

[191]  Rene Hen,et al.  The developmental origins of anxiety , 2004, Nature Reviews Neuroscience.

[192]  Y. Chida,et al.  Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice , 2004, The Journal of physiology.

[193]  M. Crowell,et al.  Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. , 2004, Gastroenterology.

[194]  R. Gaykema,et al.  Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry , 2004, Brain, Behavior, and Immunity.

[195]  P. Levitt.  Structural and functional maturation of the developing primate brain. , 2003, The Journal of pediatrics.

[196]  L. West,et al.  Species comparison of anatomical and functional immune system development. , 2003, Birth defects research. Part B, Developmental and reproductive toxicology.

[197]  G. Martin,et al.  Randomized Controlled Trial of Cognitive–Behavioral Group Therapy for Irritable Bowel Syndrome in a Medical Setting , 2003, Journal of Clinical Psychology in Medical Settings.

[198]  B. Vogt,et al.  Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome. , 2003, Gastroenterology.

[199]  James B. Young.  Programming of sympathoadrenal function , 2002, Trends in Endocrinology & Metabolism.

[200]  S. Tanada,et al.  Age-related decline of serotonin transporters in living human brain of healthy males. , 2002, Life sciences.

[201]  C. Nord,et al.  The Fecal Microflora of 1–3-Month-Old Infants during Treatment with Eight Oral Antibiotics , 2002, Infection.

[202]  C. Segebarth,et al.  Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study , 2002, American Journal of Gastroenterology.

[203]  M. Gunnar,et al.  Social regulation of the cortisol levels in early human development , 2002, Psychoneuroendocrinology.

[204]  K. Schauenstein,et al.  Serotonin and Immune Response: Effect of the Amine on in vitro Proliferation of Rat Lymphocytes , 2001, Neuroimmunomodulation.

[205]  G. Chrousos,et al.  The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system. , 2000, Pharmacological reviews.

[206]  M. Lambrecht,et al.  Indole-3-acetic acid: a reciprocal signalling molecule in bacteria-plant interactions. , 2000, Trends in microbiology.

[207]  D. Rice,et al.  Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. , 2000, Environmental health perspectives.

[208]  R. Kessler,et al.  Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention. , 2000, Gastroenterology.

[209]  J. Muñoz-Bellido,et al.  Antimicrobial activity of psychotropic drugs: selective serotonin reuptake inhibitors. , 2000, International journal of antimicrobial agents.

[210]  D. Grundy,et al.  The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinalc-fos expression in the anaesthetised rat , 2000, Gut.

[211]  M. Gershon,et al.  Serotonin and the 5-HT2B Receptor in the Development of Enteric Neurons , 2000, The Journal of Neuroscience.

[212]  C. Coe,et al.  Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. , 1999, Developmental psychobiology.

[213]  J. Rubenstein,et al.  Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling , 1999, Nature.

[214]  I. Lucki,et al.  The spectrum of behaviors influenced by serotonin , 1998, Biological Psychiatry.

[215]  M. Lyte,et al.  Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation , 1998, Physiology & Behavior.

[216]  E. Strauss,et al.  The importance of bacterial infections as precipating factors of chronic hepatic encephalopathy in cirrhosis. , 1998, Hepato-gastroenterology.

[217]  Z. Segal,et al.  Cognitive-behavioral group therapy for patients with irritable bowel syndrome. , 1998, International journal of group psychotherapy.

[218]  R. Stenling,et al.  Colonic endocrine cells in inflammatory bowel disease , 1997, Journal of internal medicine.

[219]  A. Lavdas,et al.  Serotonin Promotes the Differentiation of Glutamate Neurons in Organotypic Slice Cultures of the Developing Cerebral Cortex , 1997, The Journal of Neuroscience.

[220]  L Bueno,et al.  Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. , 1997, Gastroenterology.

[221]  T. P. Rothman,et al.  Time of origin of neurons in the murine enteric nervous system: Sequence in relation to phenotype , 1991, The Journal of comparative neurology.

[222]  G. Gebhart,et al.  Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat , 1991, Brain Research.

[223]  G. Aghajanian,et al.  Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. , 1990, Archives of general psychiatry.

[224]  T. Branchek,et al.  Time course of expression of neuropeptide Y, calcitonin gene‐related peptide, and NADPH diaphorase activity in neurons of the developing murine bowel and the appearance of 5‐hydroxytryptamine in mucosal enterochromaffin cells , 1989, The Journal of comparative neurology.

[225]  D. Morgan.  The dopamine and serotonin systems during aging in human and rodent brain. A brief review , 1987, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[226]  J. Axelrod,et al.  Stress hormones: their interaction and regulation. , 1984, Science.

[227]  D. Straus,et al.  Growth and Amino Acid Requirements of Various Strains of Group B Streptococci , 1978, Journal of clinical microbiology.

[228]  Tissari Ah.  Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny. , 1975 .

[229]  D. Savage,et al.  Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract , 1974, Infection and immunity.

[230]  J. Dobbing,et al.  Quantitative growth and development of human brain , 1973, Archives of disease in childhood.

[231]  H. Savelkoul,et al.  Immune dysregulation in autism spectrum disorder , 2013, European Journal of Pediatrics.

[232]  E. Hsiao.  Immune dysregulation in autism spectrum disorder. , 2013, International review of neurobiology.

[233]  M. Gershon.  Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. , 2012, Transactions of the American Clinical and Climatological Association.

[234]  E. Gross,et al.  BASIC AND TRANSLATIONAL — ALIMENTARY TRACT Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice , 2012 .

[235]  P. Hylemon,et al.  Linkage of gut microbiome with cognition in hepatic encephalopathy. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[236]  Taku Sato,et al.  Epithelial and Mesenchymal Cell Biology Role of a Serotonin Precursor in Development of Gut Microvilli , 2010 .

[237]  J. Csapó,et al.  Composition of the mother's milk I. Protein contents, amino acid composition, biological value (Review). , 2008 .

[238]  Hinrich W. H. Göhlmann,et al.  Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. , 2007, Gastroenterology.

[239]  D. Ardid,et al.  Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors , 2007, Nature Medicine.

[240]  V. Ocaña,et al.  Production of antimicrobial substances by lactic acid bacteria II: screening bacteriocin-producing strains with probiotic purposes and characterization of a Lactobacillus bacteriocin. , 2004, Methods in molecular biology.

[241]  J. Polak,et al.  Increased populations of endocrine cells in Crohn's ileitis , 2004, Virchows Archiv A.

[242]  P. Celada,et al.  Plasma free 5HT and platelet 5HT in depression: case-control studies and the effect of antidepressant therapy. , 1991, Advances in experimental medicine and biology.

[243]  M. Gershon.  Serotonin: its role and receptors in enteric neurotransmission. , 1991, Advances in experimental medicine and biology.

[244]  M. Metzger,et al.  Neurogenesis in the enteric nervous system. , 2010, Archives italiennes de biologie.