Auditory event-related potentials in humans and rats: effects of task manipulation.

The purpose of this study was to compare components of the rat and human auditory event-related potential (ERP) as generated in active oddball and passive single-stimulus tasks. The rats were trained to discriminate between target and standard stimuli in an oddball task, whereas the human subjects received instructions. Task effects on various ERP components were found in both species. Interestingly, effects on the P3 component were similar in the species with regard to amplitude: Target stimuli elicited a higher amplitude in the oddball task than did standard stimuli. This might indicate that the P3 shares the same characteristics between species. However, the first four components occurred 1.82 times earlier in rats than in humans, expecting a P3 of about 200 ms in rats. The P3 in rats appeared at 380 ms. We conclude that either the relation between human and rat peak latencies is not linear, or the P3 in rats is not the equivalent of the human P3.

[1]  O. Prospero-Garcia,et al.  HIV‐derived protein gp120 suppresses P3 potential in rats: potential implications in HIV‐associated dementia , 2000, Neuroreport.

[2]  A. Cools,et al.  Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval , 2001, Biological Psychology.

[3]  T Seidenbecher,et al.  Task‐relevant late positive component in rats: Is it related to hippocampal theta rhythm? , 1996, Hippocampus.

[4]  R. Freedman,et al.  Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics , 1992, Biological Psychiatry.

[5]  J. Polich,et al.  P300 from a single-stimulus paradigm: passive versus active tasks and stimulus modality. , 1997, Electroencephalography and clinical neurophysiology.

[6]  G. Rose,et al.  Neurophysiological studies of sensory gating in rats: Effects of amphetamine, phencyclidine, and haloperidol , 1986, Biological Psychiatry.

[7]  P. Robledo,et al.  Long-latency event-related potentials in rats: Effects of task and stimulus parameters , 1994, Neuroscience.

[8]  Thomas Elbert,et al.  Modulation of auditory responses during oddball tasks , 1996, Biological Psychology.

[9]  R. Näätänen.  The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function , 1990, Behavioral and Brain Sciences.

[10]  E. Donchin.  Presidential address, 1980. Surprise!...Surprise? , 1981, Psychophysiology.

[11]  E. Jodo,et al.  P3b-like potential of rats recorded in an active discrimination task. , 1995, Electroencephalography and clinical neurophysiology.

[12]  E. Garcia-Rill,et al.  Serotonergic modulation of the P13 midlatency auditory evoked potential in the rat , 2000, Brain Research Bulletin.

[13]  E. Garcia-Rill,et al.  Sensory gating of the P13 midlatency auditory evoked potential and the startle response in the rat , 1999, Brain Research.

[14]  Acquisition of discriminations involving ambiguous or non-ambiguous features: an evaluation of two configural learning models , 2001, Behavioural Processes.

[15]  J. Polich,et al.  P300 and blink instructions , 2000, Clinical Neurophysiology.

[16]  G. Rose,et al.  Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating , 1991, Brain Research.

[17]  Robert Freedman,et al.  Auditory sensory gating in hippocampal neurons: A model system in the rat , 1990, Biological Psychiatry.

[18]  R. Knight,et al.  P3-like potential in rats. , 1993, Electroencephalography and clinical neurophysiology.

[19]  C. C. Wood,et al.  Potentials evoked in human and monkey medial temporal lobe during auditory and visual oddball paradigms. , 1992, Electroencephalography and clinical neurophysiology.

[20]  Kenji Nakashima,et al.  Cortical anesthesia reduced the amplitude of local P300 event-related potential in rabbits by auditory oddball paradigm , 1998, Neuroscience Letters.

[21]  T. Shinba.  Event-related potentials of the rat during active and passive auditory oddball paradigms. , 1997, Electroencephalography and clinical neurophysiology.

[22]  G. Berntson,et al.  Effects of cocaine on sensory inhibition in rats: preliminary data , 1994, Biological Psychiatry.

[23]  H. Shibasaki,et al.  Human auditory and somatosensory event-related potentials: effects of response condition and age. , 1987, Electroencephalography and clinical neurophysiology.

[24]  N. Boutros,et al.  A Parametric Study of the N40 Auditory Evoked Response in Rats , 1997, Biological Psychiatry.

[25]  M. Molnár,et al.  On the origin of the P3 event-related potential component. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[26]  E Başar,et al.  P300 in freely moving cats with intracranial electrodes. , 1991, The International journal of neuroscience.

[27]  J. Lubar,et al.  Auditory elicitation of the P300 event-related evoked potential in the rat , 1987, Physiology & Behavior.

[28]  M. Ghilardi,et al.  P300-like potentials in the normal monkey using classical conditioning and an auditory 'oddball' paradigm. , 1986, Electroencephalography and clinical neurophysiology.

[29]  C M Michel,et al.  Event-related potential maps depend on prestimulus brain electric microstate map. , 1994, The International journal of neuroscience.

[30]  H. Meeren,et al.  Auditory evoked potentials from auditory cortex, medial geniculate nucleus, and inferior colliculus during sleep–wake states and spike-wave discharges in the WAG/Rij rat , 2001, Brain Research.

[31]  T. Shinba.  Neuronal firing activity in the dorsal hippocampus during the auditory discrimination oddball task in awake rats: relation to event-related potential generation. , 1999, Brain research. Cognitive brain research.

[32]  G. V. Simpson,et al.  Surface auditory evoked potentials in the unrestrained rat: component definition. , 1985, Electroencephalography and clinical neurophysiology.

[33]  L. Butcher,et al.  'Cat P300' disappears after septal lesions. , 1988, Electroencephalography and clinical neurophysiology.

[34]  D. Lehmann,et al.  N1 and P2 of frequent and rare event-related potentials show effects and after-effects of the attended target in the oddball-paradigm. , 1990, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[35]  F. Mauguière,et al.  Revisiting the oddball paradigm. Non-target vs neutral stimuli and the evaluation of ERP attentional effects , 1992, Neuropsychologia.