Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance.
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[1] R. Medcalf,et al. Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation. , 2005, Biochemical and biophysical research communications.
[2] M. Russell,et al. Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice , 2005, Circulation research.
[3] L. Iversen,et al. Generalized Cellular Hypertrophy is Induced by a Dual-Acting PPAR Agonist in Rat Urinary Bladder Urothelium In Vivo , 2005, Toxicologic pathology.
[4] Jennifer Y. Liu,et al. Pioglitazone initiation and subsequent hospitalization for congestive heart failure , 2005, Diabetic medicine : a journal of the British Diabetic Association.
[5] Reena Rao,et al. Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption , 2005, Nature Medicine.
[6] H. Krumholz,et al. Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project. , 2005, Diabetes care.
[7] N. Chalasani,et al. Effect of Rosiglitazone on Serum Liver Biochemistries in Diabetic Patients with Normal and Elevated Baseline Liver Enzymes , 2005, The American Journal of Gastroenterology.
[8] T. Kurtz. Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator , 2005, Acta Diabetologica.
[9] P. Nilsson. Diabetes and obesity: new data on mechanisms and intervention trials , 2005, Expert review of cardiovascular therapy.
[10] C. Long,et al. PPAR-γ activation fails to provide myocardial protection in ischemia and reperfusion in pigs , 2005 .
[11] K. Wassermann,et al. The dual PPARα/γ agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats , 2005 .
[12] B. McDermott,et al. Effects of rosiglitazone and interactions with growth-regulating factors in ventricular cell hypertrophy. , 2005, European journal of pharmacology.
[13] V. D. Hsu,et al. Impact of regulatory labeling for troglitazone and rosiglitazone on hepatic enzyme monitoring compliance: findings from the state of Ohio medicaid program , 2005, Pharmacoepidemiology and drug safety.
[14] Y. Higaki,et al. High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits. , 2005, Metabolism: clinical and experimental.
[15] P. Raskin,et al. Thiazolidinediones and Insulin , 2005, Treatments in endocrinology.
[16] Aravindan Kolandaivelu,et al. Pioglitazone-induced heart failure despite normal left ventricular function. , 2004, The American journal of medicine.
[17] Roger A. Davis,et al. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ , 2004 .
[18] R. Czekay,et al. Unexpected Role of Plasminogen Activator Inhibitor 1 in Cell Adhesion and Detachment , 2004, Experimental biology and medicine.
[19] M. Herregods,et al. Weight Loss-Associated Induction of Peroxisome Proliferator-Activated Receptor-&agr; and Peroxisome Proliferator–Activated Receptor-&ggr; Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice , 2004, Circulation.
[20] M. Cooper. The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications. , 2004, American journal of hypertension.
[21] S. Doggrell. Telmisartan – killing two birds with one stone , 2004, Expert opinion on pharmacotherapy.
[22] J. Sowers,et al. Insights into the biology of diabetic vascular disease: what's new? , 2004, American journal of hypertension.
[23] H. Münzberg,et al. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. , 2004, Endocrinology.
[24] R. Tozawa,et al. Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. , 2004, Biochemical and biophysical research communications.
[25] O. Gavrilova,et al. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. , 2004, Endocrinology.
[26] A. Tsatsoulis,et al. The edematogenic properties of insulin. , 2004, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[27] Jeremy W Tomlinson,et al. 11 (cid:1) -Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response , 2004 .
[28] R. Rosenson,et al. Association between congestive heart failure and hospitalization in patients with type 2 diabetes mellitus receiving treatment with insulin or pioglitazone: a retrospective data analysis. , 2004, Clinical therapeutics.
[29] T. Marcy,et al. Second-Generation Thiazolidinediones and Hepatotoxicity , 2004, The Annals of pharmacotherapy.
[30] I. Goldberg,et al. Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk , 2004, Current atherosclerosis reports.
[31] Lingyun Wu,et al. Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. , 2004, American journal of hypertension.
[32] J. Sheehan,et al. Fasting hyperglycemia: etiology, diagnosis, and treatment. , 2004, Diabetes technology & therapeutics.
[33] S. Welle,et al. Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes. , 2004, American journal of physiology. Endocrinology and metabolism.
[34] R. MacIsaac,et al. Thiazolidinediones and congestive heart failure—exacerbation or new onset of left ventricular dysfunction? , 2004, Diabetic medicine : a journal of the British Diabetic Association.
[35] C. Yosefy,et al. Rosiglitazone Improves, While Glibenclamide Worsens Blood Pressure Control in Treated Hypertensive Diabetic and Dyslipidemic Subjects via Modulation of Insulin Resistance and Sympathetic Activity , 2004, Journal of cardiovascular pharmacology.
[36] Cunegundo M Vergara,et al. Continuation of thiazolidinedione therapy in patients without left ventricular dysfunction who developed edema and congestive-heart-failure symptoms. , 2004, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[37] M. Quon,et al. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. , 2004, Molecular endocrinology.
[38] B. Monia,et al. Role of resistin in diet-induced hepatic insulin resistance. , 2004, The Journal of clinical investigation.
[39] T. Ohshima,et al. Transcriptional Activity of Peroxisome Proliferator-activated Receptor γ Is Modulated by SUMO-1 Modification* , 2004, Journal of Biological Chemistry.
[40] C. Thiemermann. Ligands of the peroxisome proliferator‐activated receptor‐γ and heart failure , 2004 .
[41] J. Zierath,et al. Sending the signal: molecular mechanisms regulating glucose uptake. , 2004, Medicine and science in sports and exercise.
[42] A. Palmieri,et al. Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate , 2004, Human mutation.
[43] G. Bray,et al. The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo. , 2004, Diabetes care.
[44] Marjolein Visser,et al. Re: "Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men". , 2004, American journal of epidemiology.
[45] E. Schleicher,et al. Protein Kinase C-ζ-induced Phosphorylation of Ser318 in Insulin Receptor Substrate-1 (IRS-1) Attenuates the Interaction with the Insulin Receptor and the Tyrosine Phosphorylation of IRS-1* , 2004, Journal of Biological Chemistry.
[46] M. Lazar,et al. Peroxisome proliferator-activated receptor γ in diabetes and metabolism , 2004 .
[47] I. Juhan-vague,et al. Contribution of PAI-1 in cardiovascular pathology. , 2004, Archives des maladies du coeur et des vaisseaux.
[48] J. Seufert,et al. A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus. , 2004, Clinical therapeutics.
[49] L. J. Hardies,et al. Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients , 2004, International Journal of Obesity.
[50] Donald D Hensrud,et al. Splanchnic lipolysis in human obesity. , 2004, The Journal of clinical investigation.
[51] M. Roden. How free fatty acids inhibit glucose utilization in human skeletal muscle. , 2004, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.
[52] S. Sassa,et al. Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. , 2004, Current medicinal chemistry.
[53] P. Arner,et al. Targets for TNF-α-induced lipolysis in human adipocytes , 2004 .
[54] Robert Elashoff,et al. Coronary Vasomotor Abnormalities in Insulin-Resistant Individuals , 2004, Annals of Internal Medicine.
[55] K. Wellen,et al. Interaction of Tumor Necrosis Factor-α- and Thiazolidinedione-Regulated Pathways in Obesity , 2004 .
[56] T. Funahashi,et al. Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina , 2004, Thrombosis and Haemostasis.
[57] I. G. Fantus,et al. Thiazolidinedione-Induced Congestive Heart Failure , 2004, The Annals of pharmacotherapy.
[58] A. Bonen,et al. Regulation of fatty acid transport by fatty acid translocase/CD36 , 2004, The Proceedings of the Nutrition Society.
[59] R. Lerch,et al. Insulin resistance in adult cardiomyocytes undergoing dedifferentiation: role of GLUT4 expression and translocation , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[60] M. Eren,et al. Tumor Necrosis Factor α Activates the Human Plasminogen Activator Inhibitor-1 Gene through a Distal Nuclear Factor κB Site* , 2004, Journal of Biological Chemistry.
[61] M. Lorenzo,et al. Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner* , 2004, Journal of Biological Chemistry.
[62] R. Willette,et al. Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. , 2004, Cardiovascular research.
[63] J. Flier,et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. , 2004, Diabetes.
[64] S. Borst. The role of TNF-α in insulin resistance , 2004 .
[65] M. Evans,et al. Lifestyle intervention or treatment with metformin. Which delays onset of type 2 diabetes? , 2004, Canadian family physician Medecin de famille canadien.
[66] Melissa M. Parker,et al. Use of thiazolidinediones and risk of heart failure in people with type 2 diabetes: a retrospective cohort study: response to Delea et al. , 2004, Diabetes care.
[67] D. Dazzi,et al. Pioglitazone reduces blood pressure in non-dipping diabetic patients. , 2004, Minerva endocrinologica.
[68] S. Mathur,et al. PPAR&ggr; Agonist Rosiglitazone Improves Vascular Function and Lowers Blood Pressure in Hypertensive Transgenic Mice , 2004, Hypertension.
[69] C. Bode,et al. Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones , 2004, Thrombosis and Haemostasis.
[70] A. Greenberg,et al. Adipocytokines and insulin resistance. , 2004, The Journal of clinical endocrinology and metabolism.
[71] T. Meriden. Progress with thiazolidinediones in the management of type 2 diabetes mellitus. , 2004, Clinical therapeutics.
[72] J. Verbalis,et al. Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats , 2004, Journal of Pharmacology and Experimental Therapeutics.
[73] O. McGuinness,et al. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. , 2004, Diabetes.
[74] C. Fernández-Galaz,et al. Leptin impairs insulin signaling in rat adipocytes. , 2004, Diabetes.
[75] Byung-Hyun Park,et al. Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone. , 2004, Biochemical and biophysical research communications.
[76] Frank Hu,et al. Coffee Consumption and Risk for Type 2 Diabetes Mellitus , 2004, Annals of Internal Medicine.
[77] T. Ishihara,et al. An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats , 2004, Clinical and experimental pharmacology & physiology.
[78] C. Thiemermann. Ligands of the peroxisome proliferator‐activated receptor‐γ and heart failure , 2004 .
[79] P. Galuppo,et al. Peroxisome proliferator activated‐receptor agonism and left ventricular remodeling in mice with chronic myocardial infarction , 2004, British journal of pharmacology.
[80] A. Dobrian,et al. Pioglitazone Prevents Hypertension and Reduces Oxidative Stress in Diet-Induced Obesity , 2004, Hypertension.
[81] S. Grundy,et al. Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A Consensus Statement From the American Heart Association and American Diabetes Association , 2003, Diabetes care.
[82] L. Ragolia,et al. Protein phosphatase-1 and insulin action , 1998, Molecular and Cellular Biochemistry.
[83] B. Rodrigues,et al. Metabolic disturbances in diabetic cardiomyopathy , 1998, Molecular and Cellular Biochemistry.
[84] J. Putten,et al. Corticosteroids as long-term regulators of the insulin effectiveness in mouse 3T3 adipocytes , 1985, Diabetologia.
[85] R. Denton,et al. A partial view of the mechanism of insulin action , 1981, Diabetologia.
[86] J. Carvalheira,et al. Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. , 2004, Endocrinology.
[87] M. O’connor,et al. Peroxisome Proliferator Activator Receptor-γ Ligands, 15-Deoxy-Δ12,14-Prostaglandin J2 and Ciglitazone, Reduce Systemic Inflammation in Polymicrobial Sepsis by Modulation of Signal Transduction Pathways 1 , 2003, The Journal of Immunology.
[88] V. Fonseca. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. , 2003, The American journal of medicine.
[89] N. Hollenberg. Considerations for management of fluid dynamic issues associated with thiazolidinediones. , 2003, The American journal of medicine.
[90] J. Serratosa,et al. Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. , 2003, Human molecular genetics.
[91] Stephen A. Smith,et al. Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. , 2003, The Journal of clinical endocrinology and metabolism.
[92] J. Capeau,et al. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. , 2003, Biochemical and biophysical research communications.
[93] U. Smith,et al. Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects* , 2003, Journal of Biological Chemistry.
[94] P. Drake,et al. Ragaglitazar: The Pharmacokinetics, Pharmacodynamics, and Tolerability of a Novel Dual PPARα and γ Agonist in Healthy Subjects and Patients with Type 2 Diabetes , 2003 .
[95] G. Wolf. The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis. , 2003, Nutrition reviews.
[96] D. Stein,et al. Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes. , 2003, Diabetes.
[97] G. Oster,et al. Use of thiazolidinediones and risk of heart failure in people with type 2 diabetes: a retrospective cohort study. , 2003, Diabetes care.
[98] J. Berger,et al. O-Arylmandelic acids as highly selective human PPAR α/γ agonists , 2003 .
[99] K. Kaestner,et al. Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity , 2003 .
[100] R. Chakrabarti,et al. Ragaglitazar: a novel PPARα & PPARγ agonist with potent lipid‐lowering and insulin‐sensitizing efficacy in animal models , 2003 .
[101] K. Park,et al. Peroxisome proliferator-activated receptor gamma mediated inhibition of plasminogen activator inhibitor type 1 production and proliferation of human umbilical vein endothelial cells. , 2003, Diabetes research and clinical practice.
[102] S. Mudaliar,et al. Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications. , 2003, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
[103] A. Saltiel,et al. The Roles of Cbl-b and c-Cbl in Insulin-stimulated Glucose Transport* , 2003, Journal of Biological Chemistry.
[104] A. Garg,et al. Thiazolidinedione-associated congestive heart failure and pulmonary edema. , 2003, Mayo Clinic proceedings.
[105] W. März,et al. Pioglitazone reduces atherogenic dense LDL particles in nondiabetic patients with arterial hypertension: a double-blind, placebo-controlled study. , 2003, Diabetes care.
[106] K. Nakao,et al. Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. , 2003, Diabetes care.
[107] S. Tilghman,et al. Glyceroneogenesis and the Triglyceride/Fatty Acid Cycle* , 2003, Journal of Biological Chemistry.
[108] M. Matsuda,et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. , 2003, Diabetes.
[109] Kieran Clarke,et al. The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction. , 2003, Cardiovascular research.
[110] H. Lodish,et al. Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB* , 2003, Journal of Biological Chemistry.
[111] Minghan Wang,et al. Modulation of PPARγ activity with pharmaceutical agents: Treatment of insulin resistance and atherosclerosis , 2003, Journal of cellular biochemistry.
[112] C. Long,et al. Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs. , 2003, Diabetes.
[113] B. Hoogwerf,et al. Fluid retention after initiation of thiazolidinedione therapy in diabetic patients with established chronic heart failure. , 2003, Journal of the American College of Cardiology.
[114] F. Leonetti,et al. Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity. , 2003, Obesity research.
[115] S. Verma,et al. Glitazones and heart failure: critical appraisal for the clinician. , 2003, Circulation.
[116] J. Redondo,et al. Plasminogen activator inhibitor type‐1 inhibits insulin signaling by competing with αvβ3 integrin for vitronectin binding , 2003 .
[117] P. J. Larsen,et al. PPARα/γ ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly , 2003 .
[118] S. Gray,et al. Rosiglitazone and pulmonary oedema: an acute dose-dependent effect on human endothelial cell permeability , 2003, Diabetologia.
[119] H. Imoto,et al. Studies on non-thiazolidinedione antidiabetic agents. 2. Novel oxyiminoalkanoic acid derivatives as potent glucose and lipid lowering agents. , 2003, Chemical & pharmaceutical bulletin.
[120] L. Rossetti,et al. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. , 2003, The Journal of clinical investigation.
[121] Joanna D. Holbrook,et al. Resistin is expressed in human macrophages and directly regulated by PPARγ activators , 2003 .
[122] A. Marchetti,et al. Multicenter retrospective assessment of thiazolidinedione monotherapy and combination therapy in patients with type 2 diabetes: comparative subgroup analyses of glycemic control and blood lipid levels. , 2003, Clinical therapeutics.
[123] M. Stolar,et al. Type 2 diabetes, cardiovascular risk, and the link to insulin resistance. , 2003, Clinical therapeutics.
[124] G. Chrousos,et al. Modulation of 11 beta-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. , 2003, The Journal of clinical endocrinology and metabolism.
[125] G. Shulman,et al. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.
[126] A. Takeshita,et al. Pioglitazone, a Peroxisome Proliferator-Activated Receptor-&ggr; Agonist, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction , 2002, Circulation.
[127] R. Mooney,et al. Interleukin-6 induces cellular insulin resistance in hepatocytes. , 2002, Diabetes.
[128] T. Golub,et al. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. , 2002, Diabetes.
[129] K. Murphy,et al. A comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetes. , 2002, Diabetes care.
[130] R. Hammer,et al. Glyceroneogenesis comes of age , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[131] H. Imoto,et al. Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives. , 2002, Chemical & pharmaceutical bulletin.
[132] R. A. Norman,et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. , 2002, Diabetes.
[133] M. Lazar,et al. A futile metabolic cycle activated in adipocytes by antidiabetic agents , 2002, Nature Medicine.
[134] Jasmine Chen,et al. Constitutive Activation of Peroxisome Proliferator-activated Receptor-γ Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells* , 2002, The Journal of Biological Chemistry.
[135] T. Okura,et al. Vascular Inflammation Is Negatively Autoregulated by Interaction Between CCAAT/Enhancer-Binding Protein-&dgr; and Peroxisome Proliferator-Activated Receptor-&ggr; , 2002, Circulation research.
[136] B. Staels,et al. The role of PPARs in atherosclerosis. , 2002, Trends in molecular medicine.
[137] A. Eddy. Plasminogen activator inhibitor-1 and the kidney. , 2002, American journal of physiology. Renal physiology.
[138] H. Koistinen,et al. Analysis of paradoxical observations on the association between leptin and insulin resistance , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[139] S. Cuzzocrea,et al. Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[140] T. Asano,et al. Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. , 2002, Diabetes.
[141] B. Staels,et al. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury. , 2002, Diabetes.
[142] S. Zuckerman,et al. Peroxisome proliferator-activated receptor α,γ coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice , 2002, Lipids.
[143] M. Jensen,et al. Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.
[144] Jiming Zhou,et al. Genetic analysis of four novel peroxisome proliferator activated receptor-gamma splice variants in monkey macrophages. , 2002, Biochemical and biophysical research communications.
[145] K. Ogilvie,et al. A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models. , 2002, Diabetes.
[146] K. Clarke,et al. Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart. , 2002, Diabetes.
[147] H. Uozumi,et al. Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo , 2002 .
[148] E. Olson,et al. Modulating cardiac hypertrophy by manipulating myocardial lipid metabolism? , 2002, Circulation.
[149] H. Lebovitz,et al. Differentiating members of the thiazolidinedione class: a focus on safety , 2002, Diabetes/metabolism research and reviews.
[150] S. Matsukura,et al. Early events involved in the development of insulin resistance in Zucker fatty rat , 2002, International Journal of Obesity.
[151] Vincent Lebon,et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. , 2002, Diabetes.
[152] S. O’Rahilly,et al. Induction of Adipocyte Complement-related Protein of 30 Kilodaltons by Ppar␥ Agonists: a Potential Mechanism of Insulin Sensitization , 2022 .
[153] M. Lazar,et al. The Dawn of the SPPARMs? , 2002, Science's STKE.
[154] Millard H. Lambert,et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα , 2002, Nature.
[155] Lee-Ming Chuang,et al. Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. , 2002, Diabetes care.
[156] S. Tilghman,et al. A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[157] F. Lönnqvist,et al. Mapping of Early Signaling Events in Tumor Necrosis Factor-α-mediated Lipolysis in Human Fat Cells* , 2002, The Journal of Biological Chemistry.
[158] D. S. Worrall,et al. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. , 2002, The Journal of clinical endocrinology and metabolism.
[159] J. Berger,et al. The mechanisms of action of PPARs. , 2002, Annual review of medicine.
[160] D. Moller,et al. New drug targets for type 2 diabetes and the metabolic syndrome , 2001, Nature.
[161] J. Shaw,et al. Global and societal implications of the diabetes epidemic , 2001, Nature.
[162] C. Kahn,et al. Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.
[163] J. Flier,et al. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome , 2001, Science.
[164] M. Kohno,et al. Pioglitazone Improves Left Ventricular Diastolic Function and Decreases Collagen Accumulation in Prediabetic Stage of a Type II Diabetic Rat , 2001, Journal of cardiovascular pharmacology.
[165] L. Teboul,et al. Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation. , 2001, The Biochemical journal.
[166] N. Barzilai,et al. Overfeeding rapidly induces leptin and insulin resistance. , 2001, Diabetes.
[167] W. Bao,et al. In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-&ggr; Agonist Rosiglitazone , 2001, Circulation.
[168] Y. Terauchi,et al. The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance* , 2001, The Journal of Biological Chemistry.
[169] John J. Mullins,et al. Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice* , 2001, The Journal of Biological Chemistry.
[170] C. Drevon,et al. Inhibition by insulin of resistin gene expression in 3T3‐L1 adipocytes , 2001, FEBS letters.
[171] B. Spiegelman,et al. PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth* , 2001, The Journal of Biological Chemistry.
[172] Richard T. Lee,et al. Peroxisome Proliferator-Activated Receptor &ggr; Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes , 2001, Circulation.
[173] G. Sesti,et al. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[174] S. Verma,et al. Insulin Action in the Vasculature: Physiology and Pathophysiology , 2001, Journal of Vascular Research.
[175] M. Matsuda,et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. , 2001, Diabetes.
[176] T. Tai,et al. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. , 2001, Human molecular genetics.
[177] D. Loskutoff,et al. Disruption of the plasminogen activator inhibitor‐1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[178] G. Shulman,et al. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. , 2001, Genes & development.
[179] Y. Terauchi,et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.
[180] P. Scherer,et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action , 2001, Nature Medicine.
[181] M. Roden. Non-invasive studies of glycogen metabolism in human skeletal muscle using nuclear magnetic resonance spectroscopy , 2001, Current opinion in clinical nutrition and metabolic care.
[182] S. Kushibiki,et al. Insulin resistance induced in dairy steers by tumor necrosis factor alpha is partially reversed by 2,4-thiazolidinedione. , 2001, Domestic animal endocrinology.
[183] P. Raskin,et al. A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes. , 2001, Diabetes care.
[184] G. Schmitz,et al. Adipophilin is a sensitive marker for lipid loading in human blood monocytes. , 2001, Biochimica et biophysica acta.
[185] T. Sasaoka,et al. Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ , 2001 .
[186] M. Velussi. MCC-555 (Mitsubishi-Tokyo Pharmaceuticals). , 2001, IDrugs : the investigational drugs journal.
[187] M. Cooper,et al. Regulation of Expression of 11b-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue: Tissue-Specific Induction by Cytokines* , 2001 .
[188] R. Thieringer,et al. Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity* , 2001, The Journal of Biological Chemistry.
[189] S. Kalhan,et al. Glyceroneogenesis and the Source of Glycerol for Hepatic Triacylglycerol Synthesis in Humans* , 2001, The Journal of Biological Chemistry.
[190] H. Sul,et al. A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation* , 2001, The Journal of Biological Chemistry.
[191] H. Lodish,et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[192] M. Stewart,et al. Thiazolidinediones for type 2 diabetes. All glitazones may exacerbate heart failure. , 2001, BMJ.
[193] M. Lazar,et al. The hormone resistin links obesity to diabetes , 2001, Nature.
[194] K. Ueki,et al. Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling , 2001, Molecular and Cellular Biology.
[195] E. Mayer-Davis,et al. Obesity and sedentary lifestyle: Modifiable risk factors for prevention of type 2 diabetes , 2001, Current diabetes reports.
[196] A. Saltiel,et al. The role of protein phosphatase-1 in insulin action. , 2001, Recent progress in hormone research.
[197] R. Watson,et al. Intracellular organization of insulin signaling and GLUT4 translocation. , 2001, Recent progress in hormone research.
[198] C. Rondinone,et al. Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation. , 2001, Diabetes.
[199] B. Wajchenberg. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. , 2000, Endocrine reviews.
[200] R. Ahima,et al. Adipose Tissue as an Endocrine Organ , 2006, Obesity.
[201] M. Daly,et al. Guilt by association , 2000, Nature Genetics.
[202] Eric S. Lander,et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes , 2000, Nature Genetics.
[203] E. Bruckert,et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. , 2000, The Journal of clinical endocrinology and metabolism.
[204] F. Peale,et al. FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family , 2000, The EMBO journal.
[205] U. Boelsterli,et al. Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes. , 2000, Biochemical pharmacology.
[206] R. Dina,et al. Angiotensin II-receptor antagonists: an overview. , 2000, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[207] X. Shen,et al. Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. , 2000, Diabetes.
[208] A. Saltiel,et al. Cloning and Characterization of a Functional Peroxisome Proliferator Activator Receptor-γ-responsive Element in the Promoter of the CAP Gene* , 2000, The Journal of Biological Chemistry.
[209] Roger Davis,et al. The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 * , 2000, The Journal of Biological Chemistry.
[210] G. Schwartz,et al. Troglitazone improves recovery of left ventricular function after regional ischemia in pigs. , 2000, Circulation.
[211] S. Haffner,et al. Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. , 2000, Circulation.
[212] T. Willson,et al. The PPARs: from orphan receptors to drug discovery. , 2000, Journal of medicinal chemistry.
[213] B. Spiegelman,et al. A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation* , 2000, The Journal of Biological Chemistry.
[214] A. Saltiel. Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. , 2000, The Journal of clinical investigation.
[215] C. Glass,et al. The coregulator exchange in transcriptional functions of nuclear receptors. , 2000, Genes & development.
[216] G. Shulman,et al. On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .
[217] Aldons J. Lusis,et al. Atherosclerosis : Vascular biology , 2000 .
[218] J. Corton,et al. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. , 2000, Annual review of pharmacology and toxicology.
[219] S. O’Rahilly,et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension , 1999, Nature.
[220] T. Osumi,et al. Characterization of the Amino-terminal Activation Domain of Peroxisome Proliferator-activated Receptor α , 1999, The Journal of Biological Chemistry.
[221] P. Pilch,et al. Role of PPARγ in Regulating Adipocyte Differentiation and Insulin‐Responsive Glucose Uptake , 1999, Annals of the New York Academy of Sciences.
[222] B. Spiegelman,et al. PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro , 1999 .
[223] W. Wahli,et al. Peroxisome proliferator-activated receptors: nuclear control of metabolism. , 1999, Endocrine reviews.
[224] R. Hammer,et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy , 1999, Nature.
[225] M. Kodama,et al. Troglitazone inhibits bicarbonate secretion in rat and human duodenum. , 1999, The Journal of pharmacology and experimental therapeutics.
[226] M. Quon,et al. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. , 1999, Circulation.
[227] S. Wannamethee,et al. Weight change and duration of overweight and obesity in the incidence of type 2 diabetes. , 1999, Diabetes care.
[228] J. Auwerx. PPARγ, the ultimate thrifty gene , 1999, Diabetologia.
[229] T. Ishida,et al. Thiazolidinedione inhibits the production of monocyte chemoattractant protein‐1 in cytokine‐treated human vascular endothelial cells , 1999, FEBS letters.
[230] T. Ishida,et al. Thiazolidinedione inhibits production of RANTES in a cytokine‐treated human lung epithelial cell line , 1999, FEBS letters.
[231] G. Shulman,et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. , 1999, Diabetes.
[232] J. Lehmann,et al. A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[233] T. Watanabe,et al. Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARgamma in endothelial function. , 1999, Biochemical and biophysical research communications.
[234] A. Burger,et al. Regulation of the Transcriptional Activity of the Peroxisome Proliferator-activated Receptor α by Phosphorylation of a Ligand-independent trans-Activating Domain* , 1999, The Journal of Biological Chemistry.
[235] P. Pilch,et al. Reconstitution of Insulin-sensitive Glucose Transport in Fibroblasts Requires Expression of Both PPARγ and C/EBPα* , 1999, The Journal of Biological Chemistry.
[236] B. Frohnert,et al. Identification of a Functional Peroxisome Proliferator-responsive Element in the Murine Fatty Acid Transport Protein Gene* , 1999, The Journal of Biological Chemistry.
[237] D L Rothman,et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. , 1999, The Journal of clinical investigation.
[238] J. H. Johnson,et al. Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[239] P. J. Randle,et al. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. , 1998, Diabetes/metabolism reviews.
[240] Y. Yazaki,et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. , 1998, Diabetes.
[241] M. Lazar,et al. Interdomain communication regulating ligand binding by PPAR-γ , 1998, Nature.
[242] L. Jendeberg,et al. Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARγ* , 1998, The Journal of Biological Chemistry.
[243] J. Lehmann,et al. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. , 1998, Journal of medicinal chemistry.
[244] J. Auwerx,et al. PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter , 1998 .
[245] T. Willson,et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ , 1998, Nature.
[246] N. Sato,et al. Troglitazone Reduces Plasma Leptin Concentration but Increases Hunger in NIDDM Patients , 1998, Diabetes Care.
[247] K. Siddle,et al. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. , 1998, The Biochemical journal.
[248] C. Tack,et al. Troglitazone Decreases the Proportion of Small, Dense LDL and Increases the Resistance of LDL to Oxidation in Obese Subjects , 1998, Diabetes Care.
[249] R. Tsien,et al. Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.
[250] R. Evans,et al. PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL , 1998, Cell.
[251] T. Buchanan,et al. TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus. , 1998, Controlled clinical trials.
[252] K. Umesono,et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. , 1998, The Journal of clinical investigation.
[253] M. Benito,et al. Tumor Necrosis Factor-α Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes. , 1998, Endocrinology.
[254] G. Struhl,et al. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb , 1998, Nature.
[255] H. Sul,et al. Understanding adipocyte differentiation. , 1998, Physiological reviews.
[256] B. Seed,et al. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines , 1998, Nature.
[257] R. Komers,et al. THIAZOLIDINEDIONES: TOOLS FOR THE RESEARCH OF METABOLIC SYNDROME X , 1998 .
[258] Z. Wu,et al. PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes. , 1998, The Journal of clinical investigation.
[259] Edwards,et al. 11 b-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress , 1997 .
[260] J S Yudkin,et al. Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-�, in Vivo* , 2022 .
[261] D. Leroith,et al. A Molecular Basis for Insulin Resistance , 1997, The Journal of Biological Chemistry.
[262] J. Auwerx,et al. The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene* , 1997, The Journal of Biological Chemistry.
[263] A. Saltiel,et al. Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. , 1997, The Biochemical journal.
[264] Peter J. Brown,et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ , 1997 .
[265] G. Shulman,et al. 13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat* , 1997, The Journal of Biological Chemistry.
[266] U. Smith,et al. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[267] L. Hamann,et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists , 1997, Nature.
[268] Julio E. Pérez,et al. Cardiac and Glycemic Benefits of Troglitazone Treatment in NIDDM , 1997, Diabetes.
[269] Roy J Martin,et al. Evidence for a Central Mechanism of Obesity in the Zucker Rat: Role of Neuropeptide Y and Leptin 1 , 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[270] M. Lazar,et al. Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site* , 1997, The Journal of Biological Chemistry.
[271] J. Lehmann,et al. Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs* , 1997, The Journal of Biological Chemistry.
[272] J. Stephens,et al. Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction* , 1997, The Journal of Biological Chemistry.
[273] B. Goldstein,et al. Effect of tumor necrosis factor‐α on the phosphorylation of tyrosine kinase receptors is associated with dynamic alterations in specific protein‐tyrosine phosphatases , 1997 .
[274] M. D. Leibowitz,et al. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice. , 1996, Endocrinology.
[275] P. Pekala,et al. Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. , 1996, The Biochemical journal.
[276] J. Auwerx,et al. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. , 1996, The Journal of clinical investigation.
[277] Z. Wu,et al. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids , 1996, Molecular and cellular biology.
[278] M. D. Leibowitz,et al. Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2 , 1996 .
[279] S. Yamashita,et al. Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty , 1996, Nature Medicine.
[280] K. Petersen,et al. Mechanism of free fatty acid-induced insulin resistance in humans. , 1996, The Journal of clinical investigation.
[281] M. Lazar,et al. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[282] B. Spiegelman,et al. AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (*) , 1996, The Journal of Biological Chemistry.
[283] E. Shafrir,et al. Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. , 1996, Diabetes & metabolism.
[284] C. Roberts,et al. Interaction between the Insulin Receptor and Its Downstream Effectors , 1996, The Journal of Biological Chemistry.
[285] B. Spiegelman,et al. IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance , 1996, Science.
[286] J. Lehmann,et al. The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones , 1996 .
[287] R. Considine,et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. , 1996, The New England journal of medicine.
[288] W. Wahli,et al. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. , 1996, Endocrinology.
[289] K. Umesono,et al. The nuclear receptor superfamily: The second decade , 1995, Cell.
[290] B. Spiegelman,et al. 15-Deoxy-Δ 12,14-Prostaglandin J 2 is a ligand for the adipocyte determination factor PPARγ , 1995, Cell.
[291] Philipp E. Scherer,et al. A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*) , 1995, The Journal of Biological Chemistry.
[292] M. Papa,et al. Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. , 1995, The Journal of biological chemistry.
[293] N. Copeland,et al. Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes. , 1995, European journal of biochemistry.
[294] Z. Wu,et al. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. , 1995, Genes & development.
[295] T. Buchanan,et al. Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect. , 1995, The Journal of clinical investigation.
[296] J. Lehmann,et al. An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*) , 1995, The Journal of Biological Chemistry.
[297] D. Fabbro,et al. PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid. , 1995, The EMBO journal.
[298] B. Spiegelman,et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. , 1995, The Journal of clinical investigation.
[299] R. Shulman,et al. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[300] R. Kahn. Causes of insulin resistance , 1995, Nature.
[301] S. McKnight,et al. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. , 1995, Genes & development.
[302] B. Spiegelman,et al. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene , 1995, Molecular and cellular biology.
[303] B. Spiegelman,et al. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor , 1994, Cell.
[304] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.
[305] B. Spiegelman,et al. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. , 1994, The Journal of clinical investigation.
[306] N. Ruderman,et al. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. , 1994, The Journal of biological chemistry.
[307] J. Sowers,et al. Effects of pioglitazone on calcium channels in vascular smooth muscle. , 1994, Hypertension.
[308] M. Kasuga,et al. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. , 1994, The Biochemical journal.
[309] A. Brasier,et al. Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. , 1994, Endocrinology.
[310] B. Spiegelman,et al. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[311] C. Kahn,et al. The insulin signaling system. , 1994, The Journal of biological chemistry.
[312] E. Ravussin,et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.
[313] Y. Ebina,et al. Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. , 1993, Biochemical and biophysical research communications.
[314] M. Quon,et al. Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action. , 1993, The Journal of biological chemistry.
[315] T. Kadowaki,et al. Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin. , 1993, The Journal of biological chemistry.
[316] A. Mahfoudi,et al. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[317] G. Holman,et al. Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells. , 1993, The Journal of biological chemistry.
[318] B. Spiegelman,et al. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.
[319] I. Issemann,et al. The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor. , 1993, Biochimie.
[320] B. Jhun,et al. Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling. , 1992, The Journal of biological chemistry.
[321] K. Umesono,et al. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors , 1992, Nature.
[322] R. Nordan,et al. Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. , 1992, Cancer research.
[323] J. Stephens,et al. Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. , 1992, The Journal of biological chemistry.
[324] R. Shulman,et al. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. , 1992, The Journal of clinical investigation.
[325] Christine Dreyer,et al. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors , 1992, Cell.
[326] R. DeFronzo,et al. Pathogenesis of NIDDM: A Balanced Overview , 1992, Diabetes Care.
[327] C H Lang,et al. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. , 1992, Endocrinology.
[328] S. Enerbäck,et al. The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. , 1991, The EMBO journal.
[329] J. Stephens,et al. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. , 1991, The Journal of biological chemistry.
[330] A. Vaag,et al. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus. , 1991, The Journal of clinical investigation.
[331] R. Umek,et al. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. , 1991, Genes & development.
[332] M. Mozzoli,et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. , 1991, The Journal of clinical investigation.
[333] C. Kahn,et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein , 1991, Nature.
[334] I. Issemann,et al. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.
[335] C. Grunfeld,et al. Tumor necrosis factor: immunologic, antitumor, metabolic, and cardiovascular activities. , 1990, Advances in internal medicine.
[336] R. Roth,et al. Insulin receptor structure and function in normal and pathological conditions. , 1990, Annual review of medicine.
[337] H. Horikoshi,et al. Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation. , 1989, Journal of medicinal chemistry.
[338] Yii-Der I. Chen,et al. Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM , 1988, Diabetes.
[339] B V Howard,et al. Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. , 1988, The New England journal of medicine.
[340] C. Kahn,et al. A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. , 1988, The Journal of biological chemistry.
[341] O. Rosen,et al. Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor. , 1986, The Journal of biological chemistry.
[342] M. Rao,et al. Peroxisome proliterators and cancer: mechanisms and implications , 1986 .
[343] E. Van Obberghen,et al. Two different protein kinase activities are associated with the insulin receptor. , 1983, The Biochemical journal.
[344] G. Grunberger,et al. Insulin stimulates phosphorylation of serine residues in soluble insulin receptors. , 1983, Biochemical and biophysical research communications.
[345] H. Iwatsuka,et al. Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic Agent , 1983, Diabetes.
[346] M. Cobb,et al. Phosphorylation activates the insulin receptor tyrosine protein kinase. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[347] C. Kahn,et al. Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. , 1982, The Journal of biological chemistry.
[348] B. Jeanrenaud,et al. Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane. , 1981, The Journal of biological chemistry.
[349] O. Rosen,et al. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. , 1978, The Journal of biological chemistry.
[350] J. Olefsky. The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. , 1976, The Journal of clinical investigation.
[351] H. Green,et al. An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion , 1975, Cell.
[352] E. Newsholme,et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. , 1963, Lancet.