Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library.
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J. Wells | S. Atwell | J. Ridgway | P. Carter | J A Wells | P Carter | J B Ridgway | S Atwell | J. Wells | Shane Atwell | John B. Ridgway | James A. Wells | Paul S. Carter
[1] G. P. Smith,et al. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. , 1985, Science.
[2] Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene , 1992, The Journal of experimental medicine.
[3] S. Bass,et al. Selecting high-affinity binding proteins by monovalent phage display. , 1991, Biochemistry.
[4] S. Miller. Protein-protein recognition and the association of immunoglobulin constant domains. , 1990, Journal of molecular biology.
[5] N. Scrutton,et al. Engineering surface charge. 2. A method for purifying heterodimers of Escherichia coli glutathione reductase. , 1992, Biochemistry.
[6] Phage display of peptide libraries on protein scaffolds. , 1998, Methods in molecular biology.
[7] G. Winter,et al. In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation. , 1994, Journal of molecular biology.
[8] L. Presta,et al. Engineering a humanized bispecific F(ab')2 fragment for improved binding to T cells. , 1992, International journal of cancer. Supplement = Journal international du cancer. Supplement.
[9] S. Marsters,et al. A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells. , 1994, Journal of hematotherapy.
[10] Brad Snedecor,et al. High Level Escherichia coli Expression and Production of a Bivalent Humanized Antibody Fragment , 1992, Bio/Technology.
[11] B. Quimby,et al. Heterodimer formation and activity in the human enzyme galactose-1-phosphate uridylyltransferase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[12] H. K. Schachman,et al. Shared active sites in oligomeric enzymes: model studies with defective mutants of aspartate transcarbamoylase produced by site-directed mutagenesis. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[13] F. Wurm,et al. Biological properties of a CD4 immunoadhesin , 1990, Nature.
[14] G. Winter,et al. Construction of heterodimer tyrosyl-tRNA synthetase shows tRNATyr interacts with both subunits. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[15] T. Kunkel. Rapid and efficient site-specific mutagenesis without phenotypic selection. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[16] D. Dowbenko,et al. DNA sequence analysis of the type-common glycoprotein-D genes of herpes simplex virus types 1 and 2. , 1984, DNA.
[17] R. Kelley,et al. FAB Assembly and Enrichment in a Monovalent Phage Display System , 1991, Bio/Technology.
[18] G. Winter,et al. A model of synthetase/transfer RNA interaction as deduced by protein engineering , 1986, Nature.
[19] L. Presta,et al. Remodeling domain interfaces to enhance heterodimer formation , 1997, Protein science : a publication of the Protein Society.
[20] P. Carter,et al. Engineering subtilisin BPN′ for site‐specific proteolysis , 1989, Proteins.
[21] K. J. Dorrington,et al. Structure and function of immunoglobulin domains. III. Isolation and characterization of a fragment corresponding to the Cgamma2 homology region of human immunoglobin G1. , 1976, Journal of immunology.
[22] H. M. Martinez,et al. An RNA secondary structure workbench. , 1988, Nucleic acids research.
[23] P. Carter,et al. Toward the production of bispecific antibody fragments for clinical applications. , 1995, Journal of hematotherapy.
[24] F. Sanger,et al. DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.
[25] J. Wells,et al. Hormone phage: An enrichment method for variant proteins with altered binding properties , 1990, Proteins.
[26] H. K. Schachman,et al. Regeneration of active enzyme by formation of hybrids from inactive derivatives: implications for active sites shared between polypeptide chains of aspartate transcarbamoylase. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[27] J. Deisenhofer. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. , 1981, Biochemistry.
[28] P. T. Jones,et al. Isolation of high affinity human antibodies directly from large synthetic repertoires. , 1994, The EMBO journal.
[29] E. Chen,et al. Nucleotide sequence of the alkaline phosphatase gene of Escherichia coli. , 1986, Gene.
[30] H. Heyneker,et al. Nucleotide sequence of the gene for heat-stable enterotoxin II of Escherichia coli , 1983, Infection and immunity.
[31] J. Vieira,et al. Production of single-stranded plasmid DNA. , 1987, Methods in enzymology.
[32] L. Presta,et al. Development of a humanized disulfide-stabilized anti-p185HER2 Fv-beta-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug. , 1995, Cancer research.
[33] L. Lasky,et al. Protection from genital herpes simplex virus type 2 infection by vaccination with cloned type 1 glycoprotein D. , 1985, Science.
[34] G. P. Smith,et al. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. , 1988, Gene.
[35] L. Presta,et al. 'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization. , 1996, Protein engineering.
[36] Leroy E. Hood,et al. The nucleotide sequence of a human immunoglobulin C gamma1 gene , 1982, Nucleic Acids Res..
[37] I. Kuntz,et al. Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[38] P. Carter,et al. Electrospray ionization mass spectrometry of recombinantly engineered antibody fragments. , 1994, Analytical chemistry.
[39] S. Schreiber,et al. Rational Design of Orthogonal Receptor - Ligand Combinations** , 1995 .
[40] Leroy Hood,et al. Nucleotide Sequence of a Human Immunoglobulin Cγ4 Gene , 1981 .
[41] Thomas A. Kunkel,et al. Rapid and efficient site-specific mutagenesis without phenotypic selection. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[42] A. Fersht,et al. Effects of engineering complementary charged residues into the hydrophobic subunit interface of tyrosyl-tRNA synthetase. Appendix: Kinetic analysis of dimeric enzymes that reversibly dissociate into inactive subunits. , 1987, Biochemistry.