Snippets from the past: the evolution of Wade Hampton Frost's epidemiology as viewed from the American Journal of Hygiene/Epidemiology.

Wade Hampton Frost, who was a Professor of Epidemiology at Johns Hopkins University from 1919 to 1938, spurred the development of epidemiologic methods. His 6 publications in the American Journal of Hygiene, which later became the American Journal of Epidemiology, comprise a 1928 Cutter lecture on a theory of epidemics, a survey-based study of tonsillectomy and immunity to Corynebacterium diphtheriae (1931), 2 papers from a longitudinal study of the incidence of minor respiratory diseases (1933 and 1935), an attack rate ratio analysis of the decline of diphtheria in Baltimore (1936), and a 1936 lecture on the age, time, and cohort analysis of tuberculosis mortality. These 6 American Journal of Hygiene /American Journal of Epidemiology papers attest that Frost's personal evolution mirrored that of the emerging "early" epidemiology: The scope of epidemiology extended beyond the study of epidemics of acute infectious diseases, and rigorous comparative study designs and their associated quantitative methods came to light.

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[20]  W. H. Frost,et al.  Diphtheria in Baltimore : a Comparative Study of Morbidity, Carrier Prevalence and Antitoxic Immunity in 1921-24 and 1933-36. , 1936 .

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[23]  W. H. Frost,et al.  ACUTE MINOR RESPIRATORY DISEASES PREVAILING IN A GROUP OF FAMILIES RESIDING IN BALTIMORE, MARYLAND, 1928–1930. PREVALENCE, DISTRIBUTION AND CLINICAL DESCRIPTION OF OBSERVED CASES , 1933 .

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[26]  G. Mccoy,et al.  An Epidemiological and Statistical Study of Tonsillitis, Including Related Throat Conditions , 1929 .

[27]  W. H. Frost.  Infection, immunity and disease in the epidemiology of diphtheria , 1928 .

[28]  W. Fales,et al.  CARRIERS OF DIPHTHERIA BACILLI AMONG THE SCHOOL POPULATION OF BALTIMORE , 1923 .