A three-way crossover study was conducted with 24 healthy male volunteers to determine the relative bioavailability of four different 100-mg phenobarbital tablets compared with a reference elixir. Each subject received two of the tablets and the elixir at 30-d intervals. Blood samples were collected daily for 19 d after each dose. Plasma phenobarbital concentrations achieved with the five dosage forms differed by less than 20% within 2-3 h after dosing. The extent of absorption for all dosage forms, as determined from area under the plasma concentration-time profiles, were within 10% of each other. The peak plasma concentration was the greatest and the time to peak concentration was the shortest for the elixir. One of the tablets exhibited a time to peak concentration of 8.6 h, which was significantly longer than any of the other dosage forms. The time to peak concentration correlated with the percent of drug dissolved in 60 min, as determined in 0.1 M HCl, using the USP XX paddle method at 50 rpm.
[1]
D. Perrier,et al.
Phenobarbital Pharmacokinetics and Bioavailability in Adults
,
1982,
Journal of clinical pharmacology.
[2]
K. Albert.
Drug Absorption and Disposition: Statistical Considerations
,
1981
.
[3]
N. Alvarez,et al.
Low blood levels of phenobarbital due to poor gastrointestinal solubility of phenobarbital tablets
,
1981,
Annals of neurology.
[4]
P. Welling,et al.
Pharmacokinetics of Phenobarbital Following Single and Repeated Doses
,
1979,
Journal of clinical pharmacology.
[5]
P. Welling,et al.
Bioavailability of Oral and Intramuscular Phenobarbital
,
1978,
Journal of clinical pharmacology.
[6]
William G. Cochran,et al.
Experimental Designs, 2nd Edition
,
1950
.