Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics

Ring opening of α-substituted-α-methoxycarbonyl-N-nosylaziridines provides a practical access to enantiopure α,α‘-disubstituted β-lactam scaffolds, novel types of ditopic reverse turn surrogates. The procedure is general, short, and high yielding and starts from handy α-substituted serinates and α-amino acid derivatives.