An Integrated View of Immunometabolism

[1]  Y. W.,et al.  Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity , 2018, Yearbook of Paediatric Endocrinology.

[2]  Jong Bae Seo,et al.  Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity , 2017, Cell.

[3]  P. Libby,et al.  Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease , 2017, The New England journal of medicine.

[4]  M. Donath,et al.  The Role of Inflammation in β-cell Dedifferentiation , 2017, Scientific Reports.

[5]  E. Pearce,et al.  Ancillary Activity: Beyond Core Metabolism in Immune Cells. , 2017, Cell metabolism.

[6]  T. Chenevert,et al.  Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. , 2017, Cell metabolism.

[7]  J. Mauer,et al.  IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. , 2017, Cell metabolism.

[8]  M. Czech.  Insulin action and resistance in obesity and type 2 diabetes , 2017, Nature Medicine.

[9]  M. Ivan,et al.  The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks. , 2017, Molecular cell.

[10]  M. Watt,et al.  Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance , 2017, Nature Reviews Endocrinology.

[11]  J. Elmquist,et al.  Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice , 2017, Endocrinology.

[12]  Matthew J. Potthoff,et al.  FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms. , 2017, Cell metabolism.

[13]  G. Muccioli,et al.  Obesity-Induced Neuroinflammation: Beyond the Hypothalamus , 2017, Trends in Neurosciences.

[14]  P. Venditti,et al.  Skeletal muscle insulin resistance: role of mitochondria and other ROS sources. , 2017, The Journal of endocrinology.

[15]  F. Enguita,et al.  MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance , 2017, Journal of diabetes research.

[16]  J. Olefsky,et al.  Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling , 2017, The Journal of clinical investigation.

[17]  U. V. von Andrian,et al.  Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity , 2017, Immunity.

[18]  G. Hotamışlıgil.  Inflammation, metaflammation and immunometabolic disorders , 2017, Nature.

[19]  F. Pattou,et al.  Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation , 2017, Nature Immunology.

[20]  C. Newgard,et al.  Metabolomics and Metabolic Diseases: Where Do We Stand? , 2017, Cell metabolism.

[21]  C. Kahn,et al.  Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues , 2017, Nature.

[22]  Y. Koyama,et al.  Liver inflammation and fibrosis. , 2017, The Journal of clinical investigation.

[23]  J. Brüning,et al.  Hypothalamic inflammation in obesity and metabolic disease , 2017, The Journal of clinical investigation.

[24]  C. Ballantyne,et al.  Skeletal muscle inflammation and insulin resistance in obesity , 2017, The Journal of clinical investigation.

[25]  R. Nagai,et al.  Islet inflammation in type 2 diabetes and physiology , 2017, The Journal of clinical investigation.

[26]  D. Winer,et al.  Immunologic impact of the intestine in metabolic disease , 2017, The Journal of clinical investigation.

[27]  A. Goldfine,et al.  Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. , 2017, The Journal of clinical investigation.

[28]  Wei Ying,et al.  Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance , 2016, Cell.

[29]  U. Smith,et al.  Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids , 2016, Journal of internal medicine.

[30]  Roger J. Davis,et al.  Cell Signaling and Stress Responses. , 2016, Cold Spring Harbor perspectives in biology.

[31]  D. Accili,et al.  When β‐cells fail: lessons from dedifferentiation , 2016, Diabetes, obesity & metabolism.

[32]  S. Mudaliar,et al.  Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes , 2016, PloS one.

[33]  Á. González-Rodríguez,et al.  Nuevas dianas terapéuticas para el tratamiento de la resistencia a insulina basadas en la interacción entre hepatocitos y células de Kupffer , 2016 .

[34]  J. Rathmell,et al.  A guide to immunometabolism for immunologists , 2016, Nature Reviews Immunology.

[35]  F. Heppner,et al.  High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia , 2016, Acta Neuropathologica.

[36]  P. Scherer,et al.  Targeting adipose tissue in the treatment of obesity-associated diabetes , 2016, Nature Reviews Drug Discovery.

[37]  Ian R. Lanza,et al.  Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation? , 2016, Nutrients.

[38]  L. de las Fuentes,et al.  Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. , 2016, Cell metabolism.

[39]  S. Shoelson,et al.  Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. , 2016, Cell metabolism.

[40]  Renan Corrêa-Oliveira,et al.  Regulation of immune cell function by short-chain fatty acids , 2016, Clinical & translational immunology.

[41]  Clotilde Théry,et al.  Communication by Extracellular Vesicles: Where We Are and Where We Need to Go , 2016, Cell.

[42]  Jeffrey R. Chabot,et al.  A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects. , 2016, Cell metabolism.

[43]  D. Accili,et al.  Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[44]  Mamta Rai,et al.  Systemic Nutrient and Stress Signaling via Myokines and Myometabolites. , 2016, Annual review of physiology.

[45]  R. Rizza,et al.  β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation. , 2016, The Journal of clinical endocrinology and metabolism.

[46]  J. Ehses,et al.  Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates* , 2016, The Journal of Biological Chemistry.

[47]  G. Shulman,et al.  The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. , 2016, The Journal of clinical investigation.

[48]  J. Lacy,et al.  Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans , 2015, Obesity.

[49]  Patrice D. Cani,et al.  Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling , 2015, Cell metabolism.

[50]  Bruce M. Spiegelman,et al.  Brown and Beige Fat: Physiological Roles beyond Heat Generation. , 2015, Cell metabolism.

[51]  Ellen E. Blaak,et al.  Short-chain fatty acids in control of body weight and insulin sensitivity , 2015, Nature Reviews Endocrinology.

[52]  A. Ferrante,et al.  Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity , 2015, PloS one.

[53]  Rik van der Kant,et al.  GPR43 Potentiates β-Cell Function in Obesity , 2015, Diabetes.

[54]  C. Ballantyne,et al.  Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance , 2015, International Journal of Obesity.

[55]  J. Olefsky,et al.  High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability , 2015, PloS one.

[56]  D. Accili,et al.  Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity , 2015, Molecular metabolism.

[57]  J. Olefsky,et al.  LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes , 2015, Nature Medicine.

[58]  J. Seong,et al.  Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon‐like peptide 1 in diet‐induced obesity , 2015, The FASEB Journal.

[59]  S. Klein,et al.  Metabolically normal obese people are protected from adverse effects following weight gain. , 2015, The Journal of clinical investigation.

[60]  S. Pedraza,et al.  Hypothalamic damage is associated with inflammatory markers and worse cognitive performance in obese subjects. , 2015, The Journal of clinical endocrinology and metabolism.

[61]  M. Kivimaki,et al.  The natural course of healthy obesity over 20 years. , 2015, Journal of the American College of Cardiology.

[62]  Jimmy D Bell,et al.  Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults , 2014, Gut.

[63]  F. Geissmann,et al.  Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors , 2014, Nature.

[64]  F. Tacke,et al.  Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. , 2014, Hepatobiliary surgery and nutrition.

[65]  M. Laville,et al.  Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans , 2014, PloS one.

[66]  R. Evans,et al.  Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice , 2014, Diabetes.

[67]  D. Gozal,et al.  Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. , 2014, Cell metabolism.

[68]  Jennifer R. Harris,et al.  The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies , 2014, BMC Endocrine Disorders.

[69]  J. Olefsky,et al.  Macrophages, immunity, and metabolic disease. , 2014, Immunity.

[70]  S. Yagihashi,et al.  Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients , 2014, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[71]  L. Lynch.  Adipose invariant natural killer T cells , 2014, Immunology.

[72]  Caroline Tao,et al.  Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. , 2014, Cell metabolism.

[73]  Jung-whan Kim,et al.  Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity , 2014, Cell.

[74]  C. Ling,et al.  β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment , 2014, Diabetes Care.

[75]  M. Blüher,et al.  Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans , 2014, Obesity.

[76]  S. Corvera,et al.  Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. , 2014, Biochimica et biophysica acta.

[77]  Albert Tran,et al.  M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease , 2014, Hepatology.

[78]  D. Accili,et al.  Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids , 2013, Diabetes.

[79]  R. Locksley,et al.  Type 2 innate lymphoid cells control eosinophil homeostasis , 2013, Nature.

[80]  J. Clemente,et al.  Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice , 2013, Science.

[81]  E. Van Obberghen,et al.  MicroRNAs and metabolism crosstalk in energy homeostasis. , 2013, Cell metabolism.

[82]  H. Fu,et al.  The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. , 2013, Cell metabolism.

[83]  T. Gill,et al.  Diabetes and Cardiovascular Disease Outcomes in the Metabolically Healthy Obese Phenotype , 2013, Diabetes Care.

[84]  Masahira Hattori,et al.  Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome , 2013, Nature.

[85]  Sang-Uk Seo,et al.  Role of the gut microbiota in immunity and inflammatory disease , 2013, Nature Reviews Immunology.

[86]  M. Blüher,et al.  Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes , 2013, Diabetologia.

[87]  Susan S. Taylor,et al.  The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion , 2013, Cell.

[88]  Andrea De Gaetano,et al.  Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes , 2013, Diabetes Care.

[89]  R. Locksley,et al.  Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages , 2013, The Journal of experimental medicine.

[90]  Yongjie Ma,et al.  Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance , 2013, Pharmaceutical Research.

[91]  H. Said,et al.  Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. , 2013, The American journal of pathology.

[92]  I. Hochberg,et al.  An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions , 2013, Nature Medicine.

[93]  T. Pawson,et al.  Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. , 2013, Cell metabolism.

[94]  P. Scherer,et al.  Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction , 2012, Molecular and Cellular Biology.

[95]  A. Rissanen,et al.  Effect of anti‐IL‐1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo‐controlled trial , 2012, Diabetes, obesity & metabolism.

[96]  R. Seong,et al.  A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells , 2012, Molecular and Cellular Biology.

[97]  E. Zoetendal,et al.  Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. , 2012, Gastroenterology.

[98]  S. Mukhopadhyay,et al.  Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance , 2012, Nature Medicine.

[99]  M. Donath,et al.  Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes , 2012, Diabetes Care.

[100]  Ana D. Lopez,et al.  The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells , 2012, PloS one.

[101]  K. Iwaisako,et al.  Origin of myofibroblasts in liver fibrosis , 2012, Fibrogenesis & tissue repair.

[102]  B. Kemp,et al.  The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase , 2012, Science.

[103]  B. M. Filippi,et al.  Linking Inflammation to the Brain-Liver Axis , 2012, Diabetes.

[104]  C. Glass,et al.  Inflammation and lipid signaling in the etiology of insulin resistance. , 2012, Cell metabolism.

[105]  S. Summers,et al.  A ceramide-centric view of insulin resistance. , 2012, Cell metabolism.

[106]  Hua V. Lin,et al.  Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms , 2012, PloS one.

[107]  C. Benoist,et al.  PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells , 2012, Nature.

[108]  J. Pollard,et al.  A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells , 2012, Science.

[109]  T. Kadowaki,et al.  Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. , 2012, Cell metabolism.

[110]  M. Febbraio,et al.  Muscles, exercise and obesity: skeletal muscle as a secretory organ , 2012, Nature Reviews Endocrinology.

[111]  J. Pollard,et al.  Dichotomous effects of VEGF-A on adipose tissue dysfunction , 2012, Proceedings of the National Academy of Sciences.

[112]  C. Apovian,et al.  Relation of depot-specific adipose inflammation to insulin resistance in human obesity , 2012, Nutrition & Diabetes.

[113]  Alberto Mantovani,et al.  Macrophage plasticity and polarization: in vivo veritas. , 2012, The Journal of clinical investigation.

[114]  A. Rudensky,et al.  Extrathymically generated regulatory T cells control mucosal TH2 inflammation , 2012, Nature.

[115]  K. Honda,et al.  Induction of Treg cells in the mouse colonic mucosa: a central mechanism to maintain host-microbiota homeostasis. , 2012, Seminars in immunology.

[116]  M. Dietrich,et al.  Obesity is associated with hypothalamic injury in rodents and humans. , 2012, The Journal of clinical investigation.

[117]  Dorothy D. Sears,et al.  Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity , 2011, Cell.

[118]  M. Gassmann,et al.  Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells , 2011, Nature Medicine.

[119]  C. Kahn,et al.  The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. , 2011, Cell metabolism.

[120]  L. Niskanen,et al.  Metabolically healthy and unhealthy obesity phenotypes in the general population: the FIN-D2D Survey , 2011, BMC public health.

[121]  R. Schwendener,et al.  Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance , 2011, Diabetes.

[122]  O. Gavrilova,et al.  Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice , 2011, Diabetes.

[123]  P. Sansonetti,et al.  Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment , 2011, EMBO molecular medicine.

[124]  A. Antebi,et al.  Sterol regulation of metabolism, homeostasis, and development. , 2011, Annual review of biochemistry.

[125]  J. Auwerx,et al.  The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. , 2011, Journal of hepatology.

[126]  D. Clegg,et al.  Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. , 2011, The Journal of clinical investigation.

[127]  Michael N. Alonso,et al.  B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies , 2011, Nature Medicine.

[128]  L. Joosten,et al.  Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study. , 2011, The Journal of clinical endocrinology and metabolism.

[129]  R. Locksley,et al.  Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis , 2011, Science.

[130]  J. Brüning,et al.  Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism , 2011, Nature Cell Biology.

[131]  E. Randell,et al.  The Prevalence of Metabolically Healthy Obese Subjects Defined by BMI and Dual‐Energy X‐Ray Absorptiometry , 2011, Obesity.

[132]  Fanny Cazettes,et al.  Obesity-mediated inflammation may damage the brain circuit that regulates food intake , 2011, Brain Research.

[133]  S. Akira,et al.  Pathogen Recognition by the Innate Immune System , 2011, International reviews of immunology.

[134]  Christian Gieger,et al.  Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting , 2010, PloS one.

[135]  P. Scherer,et al.  Adipokines as novel biomarkers and regulators of the metabolic syndrome , 2010, Annals of the New York Academy of Sciences.

[136]  L. Luzi,et al.  Prevalence, Metabolic Features, and Prognosis of Metabolically Healthy Obese Italian Individuals , 2010, Diabetes Care.

[137]  F. Kuipers,et al.  Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism , 2010, Hepatology.

[138]  S. Watkins,et al.  GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects , 2010, Cell.

[139]  M. Schwartz,et al.  Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. , 2010, Endocrinology.

[140]  J. Rutledge,et al.  Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[141]  F. Ortis,et al.  Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes , 2010, Diabetologia.

[142]  S. Fiorucci,et al.  FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats[S] , 2010, Journal of Lipid Research.

[143]  Dorothy D. Sears,et al.  Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice* , 2010, The Journal of Biological Chemistry.

[144]  K. Jablonski,et al.  The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes , 2010, Annals of Internal Medicine.

[145]  C. Glass,et al.  Macrophages, inflammation, and insulin resistance. , 2010, Annual review of physiology.

[146]  H. Ginsberg,et al.  C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis , 2010, Diabetes.

[147]  A. Mora,et al.  Prevention of steatosis by hepatic JNK1. , 2009, Cell metabolism.

[148]  I. Verma,et al.  Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. , 2009, Cell metabolism.

[149]  R. Friedline,et al.  Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle , 2009, Diabetes.

[150]  Christophe Benoist,et al.  Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters , 2009, Nature Medicine.

[151]  P. Dent,et al.  Bile acids as regulatory molecules , 2009, Journal of Lipid Research.

[152]  T. Kadowaki,et al.  CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity , 2009, Nature Medicine.

[153]  J. Zieleński,et al.  Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis , 2009, Nature Medicine.

[154]  N. Morgan,et al.  Islet-associated macrophages in type 2 diabetes , 2009, Diabetologia.

[155]  C. Peterson,et al.  Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. , 2009, American journal of physiology. Endocrinology and metabolism.

[156]  W. Cefalu,et al.  Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice , 2009, Diabetes.

[157]  Ralph A. DeFronzo,et al.  From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus , 2009, Diabetes.

[158]  Tsonwin Hai,et al.  Adipocyte CREB promotes insulin resistance in obesity. , 2009, Cell metabolism.

[159]  D. Bartel.  MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[160]  Philipp E. Scherer,et al.  Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI , 2008, Molecular and Cellular Biology.

[161]  A. Saltiel,et al.  Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes , 2008, Diabetes.

[162]  B. Roe,et al.  A core gut microbiome in obese and lean twins , 2008, Nature.

[163]  C. Sempoux,et al.  Pancreatic β‐cell mass in European subjects with type 2 diabetes , 2008, Diabetes, obesity & metabolism.

[164]  J. Zierath,et al.  siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle , 2008, Diabetes.

[165]  R. DeFronzo,et al.  Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects , 2008, Diabetes.

[166]  R. Bibiloni,et al.  Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice , 2008, Diabetes.

[167]  A. Goldfine,et al.  Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes , 2008, Clinical and translational science.

[168]  P. Halban,et al.  Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells , 2008, Diabetes.

[169]  U. Smith,et al.  Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice , 2008, Diabetologia.

[170]  L. Fulton,et al.  Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. , 2008, Cell host & microbe.

[171]  M. Permutt,et al.  Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis , 2008, Diabetes.

[172]  M. Membrez,et al.  Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[173]  J. Habener,et al.  Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt , 2007, Diabetes.

[174]  C. Glass,et al.  A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways* , 2007, Journal of Biological Chemistry.

[175]  D. Webb,et al.  A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. , 2007, The American journal of clinical nutrition.

[176]  G. Shulman,et al.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.

[177]  H. Ellingsgaard,et al.  Increased Number of Islet-Associated Macrophages in Type 2 Diabetes , 2007, Diabetes.

[178]  Y. Kaneda,et al.  Selective inactivation of NF-κB in the liver using NF-κB decoy suppresses CCl4-induced liver injury and fibrosis , 2007 .

[179]  J. Ferrières,et al.  Metabolic Endotoxemia Initiates Obesity and Insulin Resistance , 2007, Diabetes.

[180]  S. Kliewer,et al.  Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. , 2007, Cell metabolism.

[181]  L. Velloso,et al.  TNF-α acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient—Effects on leptin and insulin signaling pathways , 2007, Peptides.

[182]  M. Matsuda,et al.  Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation , 2007, Diabetes.

[183]  M. Febbraio,et al.  Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. , 2007, Journal of applied physiology.

[184]  Jeffrey I. Gordon,et al.  Mechanisms underlying the resistance to diet-induced obesity in germ-free mice , 2007, Proceedings of the National Academy of Sciences.

[185]  A. Saltiel,et al.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.

[186]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[187]  B. Cannon,et al.  Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively. , 2006, The Biochemical journal.

[188]  J. Flier,et al.  TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.

[189]  M. Karin,et al.  Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates , 2006, Proceedings of the National Academy of Sciences.

[190]  D. James,et al.  Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase , 2006, Diabetes.

[191]  B. Melchior,et al.  CNS immune privilege: hiding in plain sight , 2006, Immunological reviews.

[192]  D. James,et al.  Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States , 2006, Diabetes.

[193]  Christine T. N. Pham,et al.  Neutrophil serine proteases: specific regulators of inflammation , 2006, Nature Reviews Immunology.

[194]  L. Bernstein,et al.  Effects of etanercept in patients with the metabolic syndrome. , 2006, Archives of internal medicine.

[195]  Folkert Kuipers,et al.  The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice* , 2006, Journal of Biological Chemistry.

[196]  Ke Ma,et al.  Farnesoid X receptor is essential for normal glucose homeostasis. , 2006, The Journal of clinical investigation.

[197]  F. Schick,et al.  α2-Heremans-Schmid Glycoprotein/ Fetuin-A Is Associated With Insulin Resistance and Fat Accumulation in the Liver in Humans , 2006 .

[198]  Simon C Watkins,et al.  Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier , 2006, The Journal of Immunology.

[199]  Timothy M Willson,et al.  Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[200]  H. Kaneto,et al.  The Forkhead Transcription Factor Foxo1 Bridges the JNK Pathway and the Transcription Factor PDX-1 through Its Intracellular Translocation* , 2006, Journal of Biological Chemistry.

[201]  L. Velloso,et al.  Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. , 2005, Endocrinology.

[202]  A. Vaag,et al.  Metabolic and Vascular Effects of Tumor Necrosis Factor-α Blockade with Etanercept in Obese Patients with Type 2 Diabetes , 2005, Journal of Vascular Research.

[203]  F. Bäckhed,et al.  Obesity alters gut microbial ecology. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[204]  J. Gromada,et al.  FGF-21 as a novel metabolic regulator. , 2005, The Journal of clinical investigation.

[205]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[206]  S. Shoelson,et al.  Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB , 2005, Nature Medicine.

[207]  A. Drosos,et al.  Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis , 2004, Annals of the rheumatic diseases.

[208]  D. Herndon,et al.  Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus. , 2004, Immunity.

[209]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[210]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[211]  J. Chan,et al.  Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes. , 2003, Diabetes.

[212]  Michael Karin,et al.  A central role for JNK in obesity and insulin resistance , 2002, Nature.

[213]  H. Joller-jemelka,et al.  Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. , 2002, The Journal of clinical investigation.

[214]  S. Bonner-Weir,et al.  Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression* , 2002, The Journal of Biological Chemistry.

[215]  H. Hauner,et al.  Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes. , 2002, Diabetes.

[216]  M. Kruhøffer,et al.  A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells* , 2001, The Journal of Biological Chemistry.

[217]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[218]  Andrew C. Li,et al.  Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. , 2000, The Journal of clinical investigation.

[219]  J. Olefsky.  Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists , 2000 .

[220]  S. Rössner,et al.  Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue. , 2000, Diabetes.

[221]  A. Scheen,et al.  No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. , 2000, The Journal of clinical endocrinology and metabolism.

[222]  S. Bonner-Weir,et al.  Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes* , 1999, The Journal of Biological Chemistry.

[223]  C. Stevens,et al.  Contributions of microbes in vertebrate gastrointestinal tract to production and conservation of nutrients. , 1998, Physiological reviews.

[224]  Christopher K. Glass,et al.  The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation , 1998, Nature.

[225]  Roy Taylor,et al.  Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM , 1996, Diabetes.

[226]  M. Naito,et al.  Development, Differentiation, and Maturation of Fetal Mouse Yolk Sac Macrophages in Cultures , 1989, Journal of leukocyte biology.

[227]  K. Feingold,et al.  Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia. , 1989, The Journal of clinical investigation.

[228]  Luc Bouwens,et al.  Quantitation, tissue distribution and proliferation kinetics of kupffer cells in normal rat liver , 1986, Hepatology.

[229]  Jerrold M. Olefsky,et al.  Regulation of metabolism by the innate immune system , 2016, Nature Reviews Endocrinology.

[230]  Á. Valverde,et al.  New therapeutic targets for the treatment of insulin resistance based on the paracrine cross-talk between hepatocytes and Kupffer cells , 2016 .

[231]  Christopher,et al.  Diabetes and Cardiovascular Disease Outcomes in theMetabolically Healthy Obese Phenotype A cohort study , 2015 .

[232]  C. Ling,et al.  b-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and , 2014 .

[233]  C. Grunfeld,et al.  Effect of Tumor Necrosis Factor ( TNF ) on Lipid Metabolism in the Diabetic Rat , 2013 .

[234]  M. Colonna,et al.  Accepted Manuscript Association Between Specific Adipose Tissue CD 4 + T-Cell Populations and Insulin Resistance in Obese People , 2013 .

[235]  G. Pacini,et al.  Chronic TNF-α Neutralization Does Not Improve Insulin Resistance or Endothelial Function in “Healthy” Men with Metabolic Syndrome , 2011, Molecular medicine.

[236]  M. Ruth.  Normalization of obesity-associated insulin resistance through immunotherapy , 2010 .

[237]  Y. Kaneda,et al.  Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[238]  M. González-Gay,et al.  Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis. , 2006, Clinical and experimental rheumatology.

[239]  S. Shoelson,et al.  Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. , 2005, Nature medicine.

[240]  H. Joller-jemelka,et al.  Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. , 2002, The Journal of clinical investigation.

[241]  D. Schorderet,et al.  Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. , 2001, Diabetes.

[242]  R. Evans,et al.  PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation , 2001, Nature Medicine.

[243]  D. Schorderet,et al.  Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of β-Cell Death , 2001 .

[244]  J. Olefsky.  Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. , 2000, The Journal of clinical investigation.

[245]  D. Brenner,et al.  The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. , 1999, Journal of hepatology.

[246]  J. Northrop,et al.  TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression. , 1997, Endocrinology.

[247]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.