SARS-CoV-2 Nsp13 is a viral RHIM protein promoting cell death linked to Z-RNA sensing and ZBP1-RIPK3 signaling
暂无分享,去创建一个
Oyahida Khatun | Shashank Tripathi | M. Ganji | M. Srivastava | S. Kesavardhana | Disha Jain | Keerthana Balamurugan | Sanchita Mishra | Micky Anand | S. Tripathi | Sahana Nagaraja | Shashank | Ayushi Amin Dey | Mansi | Srivastava | Tripathi
[1] J. Rehwinkel,et al. The Z-nucleic acid sensor ZBP1 in health and disease , 2023, The Journal of experimental medicine.
[2] S. Darst,et al. A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance , 2023, mBio.
[3] S. Balachandran,et al. Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: waalking the razor's edge. , 2023, Current opinion in immunology.
[4] T. Kanneganti,et al. PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis. , 2023, Current opinion in immunology.
[5] B. Shapiro,et al. Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis , 2023, bioRxiv.
[6] B. Lu,et al. SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses , 2023, Cell Research.
[7] B. tenOever,et al. Innate immune evasion strategies of SARS-CoV-2 , 2023, Nature Reviews Microbiology.
[8] J. Ragoussis,et al. Evolution of naturally arising SARS-CoV-2 defective interfering particles , 2022, Communications Biology.
[9] D. Mathews,et al. Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection , 2022, bioRxiv.
[10] O. Elemento,et al. Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19 , 2022, Science Immunology.
[11] A. Oberst,et al. ADAR1 mutation causes ZBP1-dependent immunopathology , 2022, Nature.
[12] P. Vandenabeele,et al. ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation , 2022, Nature.
[13] Yan Xu,et al. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis , 2022, Nature.
[14] Shondra M. Pruett-Miller,et al. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection , 2022, Science Immunology.
[15] S. Kesavardhana,et al. Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation , 2022, mBio.
[16] R. Horres,et al. Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host , 2022, Nature Communications.
[17] M. Poptsova,et al. Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology? , 2022, bioRxiv.
[18] Xiang Li,et al. Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death , 2022, Nature Cell Biology.
[19] M. Bathe,et al. Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells , 2022, Nature Communications.
[20] D. Shaw,et al. Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex , 2022, Nature Structural & Molecular Biology.
[21] M. Diamond,et al. Innate immunity: the first line of defense against SARS-CoV-2 , 2022, Nature Immunology.
[22] Zhaohui Qian,et al. The stalk domain of SARS-CoV-2 NSP13 is essential for its helicase activity , 2022, Biochemical and Biophysical Research Communications.
[23] S. Perlman,et al. Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy? , 2021, Nature reviews. Immunology.
[24] D. Shaw,et al. Ensemble cryo-electron microscopy reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex , 2021, bioRxiv.
[25] R. Andino,et al. A defective viral genome strategy elicits broad protective immunity against respiratory viruses , 2021, Cell.
[26] S. Balachandran,et al. Viral Z-RNA triggers ZBP1-dependent cell death. , 2021, Current opinion in virology.
[27] G. Neale,et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. , 2021, Cell reports.
[28] J. Rehwinkel,et al. Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses , 2021, Immunity.
[29] D. Schatz,et al. Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme , 2021, Science.
[30] Beat Vögeli,et al. Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA , 2021, International journal of molecular sciences.
[31] S. Kesavardhana,et al. Inflammasome regulation in driving COVID‐19 severity in humans and immune tolerance in bats , 2021, Journal of leukocyte biology.
[32] David F. Boyd,et al. Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract , 2021, Nature Reviews Microbiology.
[33] F. von Delft,et al. Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase , 2021, Nature Communications.
[34] E. Miska,et al. In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs , 2021, Cell.
[35] Lin‐Fa Wang,et al. Lessons from the host defences of bats, a unique viral reservoir , 2021, Nature.
[36] Daniel A. Jacobson,et al. Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models , 2020, Genome biology.
[37] R. Webby,et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes , 2020, Cell.
[38] Z. Rao,et al. Architecture of a SARS-CoV-2 mini replication and transcription complex , 2020, Nature Communications.
[39] P. Zhou,et al. Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection , 2020, Cell Reports.
[40] Peng Zhou,et al. SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation , 2020, Signal Transduction and Targeted Therapy.
[41] A. Pyle,et al. Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms , 2020, bioRxiv.
[42] B. Chait,et al. Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex , 2020, bioRxiv.
[43] T. Kanneganti,et al. ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease , 2020, The Journal of experimental medicine.
[44] T. Kanneganti,et al. Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) , 2020, Frontiers in Cellular and Infection Microbiology.
[45] Shondra M. Pruett-Miller,et al. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development , 2020, The Journal of Biological Chemistry.
[46] M. Sunde,et al. Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death , 2020, bioRxiv.
[47] David F. Boyd,et al. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis , 2020, Cell.
[48] Ting Yu,et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study , 2020, The Lancet Respiratory Medicine.
[49] M. Pasparakis,et al. Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation , 2020, Nature.
[50] Kai Zhao,et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin , 2020, Nature.
[51] P. Thomas,et al. ZBP1/DAI-Dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis. , 2020, Current topics in microbiology and immunology.
[52] C. López,et al. The Impact of Defective Viruses on Infection and Immunity. , 2019, Annual review of virology.
[53] M. Vignuzzi,et al. Defective viral genomes are key drivers of the virus–host interaction , 2019, Nature Microbiology.
[54] Hao Wu,et al. Mimicry by a viral RHIM , 2019, EMBO reports.
[55] Zhènglì Shí,et al. Origin and evolution of pathogenic coronaviruses , 2018, Nature Reviews Microbiology.
[56] M. Sunde,et al. Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies , 2018, EMBO reports.
[57] Yan Xu,et al. 2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA , 2018, Molecules.
[58] T. Kepler,et al. The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity , 2018, Cell.
[59] A. García-Sastre. Ten Strategies of Interferon Evasion by Viruses , 2017, Cell Host & Microbe.
[60] T. Kanneganti,et al. ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death , 2017, The Journal of experimental medicine.
[61] Maximilian T. Strauss,et al. Super-resolution microscopy with DNA-PAINT , 2017, Nature Protocols.
[62] D. Green,et al. Necroptosis in development, inflammation and disease , 2016, Nature Reviews Molecular Cell Biology.
[63] David F. Boyd,et al. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. , 2016, Cell host & microbe.
[64] A. Strasser,et al. RIPK1 inhibits ZBP1-driven necroptosis during development , 2016, Nature.
[65] M. Bertrand,et al. An evolutionary perspective on the necroptotic pathway. , 2016, Trends in cell biology.
[66] Oliver E. Sturm,et al. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. , 2016, Cell host & microbe.
[67] Lisa E. Gralinski,et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence , 2015, Nature Medicine.
[68] P. A. Harris,et al. Herpes simplex virus suppresses necroptosis in human cells. , 2015, Cell host & microbe.
[69] Judith N. Mandl,et al. Reservoir Host Immune Responses to Emerging Zoonotic Viruses , 2014, Cell.
[70] K. Hofmann,et al. Evolutionary link between metazoan RHIM motif and prion-forming domain of fungal heterokaryon incompatibility factor HET-s/HET-s , 2014, Scientific Reports.
[71] Qin Chen,et al. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense , 2014, Proceedings of the National Academy of Sciences.
[72] W. Kaiser,et al. Viral modulation of programmed necrosis. , 2013, Current opinion in virology.
[73] S. Perlman. Faculty Opinions recommendation of Comparative analysis of bat genomes provides insight into the evolution of flight and immunity. , 2013 .
[74] Lijun Wu,et al. Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity , 2013, Science.
[75] Ming Yi,et al. Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools , 2012, Nucleic Acids Res..
[76] Kenta Moriwaki,et al. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis , 2012, Cell.
[77] Mathias Jucker,et al. The Amyloid State of Proteins in Human Diseases , 2012, Cell.
[78] W. Kaiser,et al. DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. , 2012, Cell host & microbe.
[79] W. Kaiser,et al. Virus inhibition of RIP3-dependent necrosis. , 2010, Cell host & microbe.
[80] David H. Mathews,et al. RNAstructure: software for RNA secondary structure prediction and analysis , 2010, BMC Bioinformatics.
[81] F. Chan,et al. Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation , 2009, Cell.
[82] F. Tay,et al. An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells , 2006, Virology.
[83] J. Ziebuhr,et al. A Complex Zinc Finger Controls the Enzymatic Activities of Nidovirus Helicases , 2005, Journal of Virology.
[84] V. Dixit,et al. Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3* , 2002, The Journal of Biological Chemistry.
[85] I. Tinoco,et al. ‘Z-RNA’—a left-handed RNA double helix , 1984, Nature.
[86] A. Rich,et al. The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions. , 1981, Nucleic acids research.
[87] T. Kanneganti,et al. Caspases in Cell Death, Inflammation, and Pyroptosis , 2020 .
[88] Si Ming Man,et al. ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. , 2016, Science immunology.
[89] A. Rich,et al. A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1. , 2007, Structure.
[90] Mariusz Popenda,et al. High salt solution structure of a left-handed RNA double helix. , 2004, Nucleic acids research.