Scurvy, Megaloblastic Anaemia and Osteoporosis

Clinical scurvy in the adult is uncommon in this country so that the opportunities for observing its complications are infrequent. One of these, megaloblastic anaemia, is well recognized, but osteoporosis of a degree sufficient to produce crush fractures of vertebrae is rare. This paper records observations on a patient with scurvy complicated by megaloblastic anaemia and osteoporosis who was treated with vitamin C as the sole medication.

[1]  W. Cooke,et al.  Scurvy and anaemia. , 1962, The American journal of medicine.

[2]  B. La Du,et al.  THE ROLE OF ASCORBIC ACID IN TYROSINE METABOLISM , 1961, Annals of the New York Academy of Sciences.

[3]  A. Mazur.  ROLE OF ASCORBIC ACID IN THE INCORPORATION OF PLASMA IRON INTO FERRITIN * , 1961, Annals of the New York Academy of Sciences.

[4]  W. R. Murdoch,et al.  Megaloblastic Anaemia Associated with Adult Scurvy , 1960, Postgraduate medical journal.

[5]  V. Doctor.  Role of reducing agents, adrenal glands, and pituitary glands on the conversion of folic acid to citrovorum factor. , 1960, Endocrinology.

[6]  E. H. Back,et al.  Megaloblastic Anaemia of Infancy in Jamaica , 1960, Archives of disease in childhood.

[7]  James McE. Neilson.  Megaloblastic Anaemia in Scurvy Report of a Case , 1960, Scottish medical journal.

[8]  R. Girdwood.  The role of folic acid in the blood disorders. , 1959, British medical bulletin.

[9]  B. Anderson,et al.  The Clearance from the Plasma of Folic Acid Injected Intravenously in Normal Subjects and Patients with Megaloblastic Anaemia , 1958, British journal of haematology.

[10]  E. Samuel,et al.  A syndrome of osteoporosis in Africans and its relationship to scurvy. , 1957, The American journal of clinical nutrition.

[11]  K. Shaw,et al.  3-Methoxy-4-hydroxy-D-mandelic acid, a urinary metabolite of norepinephrine. , 1957, Biochimica et biophysica acta.

[12]  M. Silverman,et al.  LABILE CITROVORUM FACTOR IN URINE , 1956, Journal of bacteriology.

[13]  A. Brown.  Megaloblastic Anaemia associated with Adult Scurvy: Report of a case which responded to Synthetic Ascorbic Acid alone , 1955, British journal of haematology.

[14]  C. M. Young,et al.  Blood lipid levels as influenced by weight reduction in men. , 1955, The American journal of clinical nutrition.

[15]  J. F. Rinehart,et al.  Serum Iron Levels in Rhesus Monkeys with Chronic Vitamin C Deficiency.∗ , 1955, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[16]  J. J. Will,et al.  Interrelationship of folic acid, vitamin B12 and ascorbic acid in patients with megaloblastic anemia. , 1955, The American journal of clinical nutrition.

[17]  V. Doctor,et al.  In vivo and In vitro Conversion of Folic Acid to Citrovorum Factor by Rat.∗ , 1954, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[18]  P. Kincaid‐smith,et al.  Scurvy in adult Africans; a clinical, haematological, and pathological study. , 1954, The American journal of clinical nutrition.

[19]  C. Merskey.  Survival of Transfused Red Cells in Scurvy , 1953, British medical journal.

[20]  C. May,et al.  Experimental megaloblastic anemia and scurvy in the monkey. V. Nature of the relation of ascorbic acid deficiency to the metabolism of folic acid compounds. , 1953, The Journal of nutrition.

[21]  R. G. Holly.  Megaloblastic Anemia in Pregnancy. Remission Following Combined Therapy with Ascorbic Acid and Vitamin B12.∗ , 1951, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[22]  C. May,et al.  Pathogenesis of megaloblastic anemia in infancy; an interrelationship between pteroglutamic acid and ascorbic acid. , 1950, American journal of diseases of children.

[23]  C. A. Nichol,et al.  Synthesis of Citrovorum Factor From Folic Acid By Liver Slices; Augmentation By Ascorbic Acid.∗ , 1950, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[24]  N. Doblhamer.  Vitamin B12. , 1950, Wiener medizinische Wochenschrift.

[25]  H. H. Gordon,et al.  The Effect of Pteroylglutamic Acid on the Aromatic Amino Acid Metabolism of Premature Infants. , 1949, Science.

[26]  H. Painter,et al.  The influence of l-ascorbic acid on the rupture of the benzene ring of l-tyrosine consumed in high doses by guinea-pigs. , 1947, The Biochemical journal.

[27]  W. Zuelzer,et al.  Megaloblastic anemia in infancy; a common syndrome responding specifically to folic acid therapy. , 1946, American journal of diseases of children.

[28]  R. B. McMillan,et al.  Scurvy: A Survey of 53 Cases , 1944, British medical journal.

[29]  S. Wolbach,et al.  TISSUE CHANGES IN VITAMIN DEFICIENCIES , 1942 .

[30]  S. Sherry,et al.  ADULT SCURVY AND THE METABOLISM OF VITAMIN C , 1941 .

[31]  S. H. Liu,et al.  Anemia in Vitamin C Deficiency and Its Response to Iron , 1941 .

[32]  H. H. Gordon,et al.  A DEFECT IN THE METABOLISM OF AROMATIC AMINO ACIDS IN PREMATURE INFANTS: THE ROLE OF VITAMIN C. , 1939, Science.

[33]  H. C. Aron.  The relation of vitamin C deficiency to nutritional anemia. , 1939 .

[34]  J. D. Croft,et al.  CEVITAMIC ACID DEFICIENCY.: FREQUENCY IN A GROUP OF 100 UNSELECTED PATIENTS , 1939 .

[35]  C. J. Farmer,et al.  THE BLOOD PLASMA ASCORBIC ACID IN PATIENTS WITH ACHLORHYDRIA (PERNICIOUS AND IRON DEFICIENCY ANEMIA) , 1939 .

[36]  A. Glazebrook,et al.  Clinical and Blood Pictures in Adult Scurvy , 1938, British medical journal.

[37]  A. Cohen,et al.  ADULT SCURVY; STUDY OF THE URINARY OUTPUT OF CEVITAMIC ACID , 1937 .

[38]  S. Wolbach.  THE PATHOLOGIC CHANGES RESULTING FROM VITAMIN DEFICIENCY , 1937 .

[39]  W. Mcfarlane.  Some observations on the reduction of iron by tissue extracts and by ascorbic acid, with a note on the stabilization of ascorbic acid solutions. , 1936, The Biochemical journal.

[40]  W. C. Smallwood,et al.  Studies in the anaemia of infancy and early childhood , 1935, Archives of disease in childhood.

[41]  E. A. Park,et al.  The recognition of scurvy with especial reference to the early x-ray changes , 1935, Archives of disease in childhood.

[42]  L. Parsons,et al.  Studies in the Anæmias of Infancy and Early Childhood , 1933, Archives of disease in childhood.

[43]  W. Townsend,et al.  SCURVY IN ADULTS: ESPECIALLY THE EFFECT OF FOOD RICH IN VITAMIN C ON BLOOD FORMATION , 1930 .

[44]  H. Harris.  The Histological and Radiographic of Appearance of Infantile Scurvy (Barlow's Disease) , 1928 .