Pathoadaptive mutations: gene loss and variation in bacterial pathogens.

Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

[1]  W. L. Payne,et al.  High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens , 1996, Science.

[2]  M. Kimura,et al.  The neutral theory of molecular evolution. , 1983, Scientific American.

[3]  Transmission of uropathogens between sex partners. , 1997, The Journal of infectious diseases.

[4]  J. Bull,et al.  Short-sighted evolution and the virulence of pathogenic microorganisms. , 1994, Trends in microbiology.

[5]  M. Nishibuchi,et al.  Manifestation of the Kanagawa phenomenon, the virulence‐associated phenotype, of Vibrio parahaemolyticus depends on a particular single base change in the promoter of the thermostable direct haemolysin gene , 1998, Molecular microbiology.

[6]  J. Miller,et al.  Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repair. , 1996, Annual review of microbiology.

[7]  P. Hedrick.  GENETIC POLYMORPHISM IN HETEROGENEOUS ENVIRONMENTS: A DECADE LATER , 1986 .

[8]  T. Pitt,et al.  Auxotrophic variants of Pseudomonas aeruginosa are selected from prototrophic wild-type strains in respiratory infections in patients with cystic fibrosis , 1995, Journal of clinical microbiology.

[9]  J Hacker,et al.  Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution , 1997, Molecular microbiology.

[10]  F. Gunzer,et al.  The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coli infection , 1995, Infection and immunity.

[11]  M. Skurnik,et al.  Increased virulence of Yersinia pseudotuberculosis by two independent mutations , 1988, Nature.

[12]  C. Sasakawa,et al.  The absence of a surface protease, OmpT, determines the intercellular spreading ability of Shigella: the relationship between the ompT and kcpA loci , 1993, Molecular microbiology.

[13]  D. Berg,et al.  Adaptive mutation and cocolonization during Helicobacter pylori infection of gnotobiotic piglets , 1995, Infection and immunity.

[14]  C. Bloch,et al.  A key role for type 1 pili in enterobacterial communicability , 1992, Molecular microbiology.

[15]  F. Taddei,et al.  To be a mutator, or how pathogenic and commensal bacteria can evolve rapidly. , 1997, Trends in microbiology.

[16]  S. Falkow.  What is a pathogen , 1997 .

[17]  D. Berg,et al.  Emergence of recombinant strains of Helicobacter pylori during human infection , 1999, Molecular microbiology.

[18]  K. E. Shroff,et al.  Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut , 1995, Infection and immunity.

[19]  K. Millman,et al.  Molecular and mutation trends analyses of omp1 alleles for serovar E of Chlamydia trachomatis. Implications for the immunopathogenesis of disease. , 1997, The Journal of clinical investigation.

[20]  R. Proctor,et al.  A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly , 1997, Journal of bacteriology.

[21]  V. Deretic,et al.  Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection , 1997, Infection and immunity.

[22]  E. Moxon,et al.  An ancestral mutation enhancing the fitness and increasing the virulence of Haemophilus influenzae type b. , 1993, The Journal of infectious diseases.

[23]  J. Galán.  'Avirulence genes' in animal pathogens? , 1998, Trends in microbiology.

[24]  J. Hacker,et al.  Amino acid residue Ala‐62 in the FimH fimbrial adhesin is critical for the adhesiveness of meningitis‐associated Escherichia coli to collagens , 1999, Molecular microbiology.

[25]  M. Hanes,et al.  Microbial Pathogenesis in Cystic Fibrosis: Pulmonary Clearance of Mucoid Pseudomonas aeruginosa and Inflammation in a Mouse Model of Repeated Respiratory Challenge , 1998, Infection and Immunity.

[26]  E. Mahenthiralingam,et al.  Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis , 1994, Infection and immunity.