Openings between defective endothelial cells explain tumor vessel leakiness.
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R K Jain | R. Jain | D. McDonald | G. Thurston | P. Baluk | H. Hashizume | S. Morikawa | J. McLean | S. Roberge | H Hashizume | P Baluk | S Morikawa | J W McLean | G Thurston | S Roberge | D M McDonald | J. Mclean
[1] D. McDonald,et al. Determinants of Endothelial Cell Phenotype in Venules , 2000, Microcirculation.
[2] Thomas N. Sato,et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. , 1999, Science.
[3] P. Meltzer,et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. , 1999, The American journal of pathology.
[4] G. Yancopoulos,et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. , 1999, Science.
[5] D. Bates,et al. Vascular Endothelial Growth Factor and Microvascular Permeability , 1999, Microcirculation.
[6] K. Alitalo,et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. , 1999, American Journal of Pathology.
[7] D. McDonald,et al. Endothelial Gaps as Sites for Plasma Leakage in Inflammation , 1999, Microcirculation.
[8] C. Michel,et al. Openings Through Endothelial Cells Associated with Increased Microvascular Permeability , 1999, Microcirculation.
[9] H. Dvorak,et al. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. , 1999, Current topics in microbiology and immunology.
[10] D M Shames,et al. Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small-molecular contrast media. , 1998, AJR. American journal of roentgenology.
[11] W. Cavenee,et al. Host microvasculature influence on tumor vascular morphology and endothelial gene expression. , 1998, The American journal of pathology.
[12] R K Jain,et al. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[13] L. Kindblom,et al. Angiosarcoma of soft tissue: a study of 80 cases. , 1998, The American journal of surgical pathology.
[14] R. Jain. The next frontier of molecular medicine: Delivery of therapeutics , 1998, Nature Medicine.
[15] P. Hutzler,et al. Lectin Intravital Perfusion Studies in Tumor-bearing Mice: Micrometer-resolution, Wide-area Mapping of Microvascular Labeling, Distinguishing Efficiently and Inefficiently Perfused Microregions in the Tumor , 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[16] R. Jain,et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[17] D. Hanahan,et al. Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice. , 1998, The Journal of clinical investigation.
[18] R. Jain,et al. Delivery of Molecular and Cellular Medicine to Solid Tumors , 1997, Advanced drug delivery reviews.
[19] N. van Bruggen,et al. Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. , 1998, Cancer investigation.
[20] D. Hanahan,et al. Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. , 1998, The International journal of developmental biology.
[21] H. Dvorak,et al. Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea‐fig, mouse and rat: many are transcellular pores , 1997, The Journal of physiology.
[22] W. Cavenee,et al. Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[23] D. McDonald,et al. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice. , 1997, The American journal of physiology.
[24] W. Risau,et al. Mechanisms of angiogenesis , 1997, Nature.
[25] R K Jain,et al. Geometric Resistance and Microvascular Network Architecture of Human Colorectal Carcinoma , 1997, Microcirculation.
[26] G. Palade,et al. Neovasculature induced by vascular endothelial growth factor is fenestrated. , 1997, Cancer research.
[27] William Arbuthnot Sir Lane,et al. Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth , 1997, Cell.
[28] D. McDonald,et al. Endothelial gaps: time course of formation and closure in inflamed venules of rats. , 1997, The American journal of physiology.
[29] R. Jain. The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors. , 1997, Microcirculation.
[30] I. O. Ellis,et al. Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast. , 1997, British Journal of Cancer.
[31] D. McDonald,et al. Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding. , 1996, The American journal of physiology.
[32] R. Jain,et al. Perfusion of Single Tumor Microvessels: Application to Vascular Permeability Measurement , 1996, Microcirculation.
[33] R. Jain,et al. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. , 1996, Microvascular research.
[34] R. Brasch,et al. Contrast-enhanced MR imaging assessment of tumor capillary permeability: effect of irradiation on delivery of chemotherapy. , 1996, Radiology.
[35] H. Dvorak,et al. The vesiculo‐vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation , 1996, Journal of leukocyte biology.
[36] E. Lander,et al. Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma. , 1995, Cancer research.
[37] David A. Cheresh,et al. Definition of Two Angiogenic Pathways by Distinct αv Integrins , 1995, Science.
[38] R K Jain,et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.
[39] C Danieli,et al. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products , 1995, The Journal of experimental medicine.
[40] H. Dvorak,et al. Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. , 1995, International archives of allergy and immunology.
[41] E. van Marck,et al. Microvessel quantification in primary colorectal carcinoma: an immunohistochemical study. , 1995, British Journal of Cancer.
[42] E. Manseau,et al. Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining. , 1995, Cancer research.
[43] H. Dvorak,et al. Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. , 1995, Cancer research.
[44] M A Konerding,et al. Microvascular corrosion casting in the study of tumor vascularity: a review. , 1995, Scanning microscopy.
[45] D. Cheresh,et al. Definition of two angiogenic pathways by distinct alpha v integrins. , 1995, Science.
[46] D. McDonald. Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli. , 1994, The American journal of physiology.
[47] K. Honn,et al. Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium. , 1993, The Journal of biological chemistry.
[48] S. Albelda,et al. Expression of platelet‐endothelial cell adhesion molecule‐1 (PECAM‐1) during melanoma‐induced angiogenesis in vivo , 1993, Journal of cutaneous pathology.
[49] R. Jain,et al. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. , 1992, Cancer research.
[50] H. Dvorak,et al. Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels. , 1992, Laboratory investigation; a journal of technical methods and pathology.
[51] L. Liotta,et al. Cancer cell invasion and metastasis. , 1992, Scientific American.
[52] R. Jain,et al. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. , 1991, Cancer research.
[53] I. McLean,et al. Traumatic enucleation for posterior uveal melanoma. , 1990, American journal of ophthalmology.
[54] D. Hanahan,et al. Transgenic mice as probes into complex systems. , 1989, Science.
[55] M. Trotter,et al. The use of fluorescent probes to identify regions of transient perfusion in murine tumors. , 1989, International journal of radiation oncology, biology, physics.
[56] M A Konerding,et al. The vascular system of xenotransplanted tumors--scanning electron and light microscopic studies. , 1989, Scanning microscopy.
[57] H. Dvorak,et al. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. , 1988, The American journal of pathology.
[58] J. Schechter,et al. Estrogen-induced tumors: changes in the vasculature in two strains of rat. , 1987, The American journal of anatomy.
[59] J. Tew,et al. The relationship between the capillary structure and hemorrhage in gliomas. , 1987, Journal of neurosurgery.
[60] R. Jain,et al. Microvascular permeability of normal and neoplastic tissues. , 1986, Microvascular research.
[61] D. Hanahan,et al. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. , 1985, Nature.
[62] L. Orci,et al. Endothelial fenestral diaphragms: a quick-freeze, deep-etch study , 1985, The Journal of cell biology.
[63] K. Messmer,et al. The fine structure of tumor blood vessels. I. Participation of non-endothelial cells in tumor angiogenesis. , 1985, International journal of microcirculation, clinical and experimental.
[64] N. Kumano,et al. Ultrastructure of the Lewis lung carcinoma. , 1982, European journal of cancer & clinical oncology.
[65] K. Messmer,et al. Microcirculatory blood flow, capillary morphology and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3. , 1982, Journal of the National Cancer Institute.
[66] C. Finch,et al. Pituitary tumorigenesis in aging female C57BL/6J mice: A light and electron microscopic study , 1981, The Anatomical record.
[67] Hans-Inge Peterson,et al. Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors , 1979 .
[68] Toshio Tanaka,et al. HEMANGIOSARCOMA OF THE BREAST—CASE REPORT WITH SCANNING ELECTRON MICROSCOPIC STUDY— , 1978, Acta pathologica japonica.
[69] J. Folkman,et al. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. , 1977, Microvascular research.
[70] M. Stone,et al. The significance of free blood in liquid and solid tumours. , 1977, British journal of experimental pathology.
[71] H. Peterson,et al. Tumour vessel permeability and transcapillary exchange of large molecules of different size. , 1977, Bibliotheca anatomica.
[72] P. Lantos,et al. The fine structure of blood vessels in ethylnitrosourea-induced tumours of the rat nervous system: with special reference to the breakdown of the blood-brain barrier. , 1976, British journal of experimental pathology.
[73] B. Tóth,et al. Scanning electron‐microscopic study of the surface characteristics of neoplastic endo‐thelial cells of blood vessels , 1976, The Journal of pathology.
[74] J. Papadimitriou,et al. Structural and functional characteristics of the microcirculation in neoplasms , 1975, The Journal of pathology.
[75] B. Warren,et al. Tumour angiogenesis: ultrastructure of endothelial cells in mitosis. , 1972, British journal of experimental pathology.
[76] J. Schechter. Ultrastructural changes in the capillary bed of human pituitary tumors. , 1972, The American journal of pathology.
[77] G. Palade,et al. STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study , 1961 .
[78] V. Menkin. STUDIES ON INFLAMMATION , 1931, The Journal of experimental medicine.