Energetic constraints in adaptive gene expression responses of yeast under environmental changes

adaptive response of yeast under stress requires the synthesis of protective molecules that help minimizing cellular damage. The amount and type of these molecules depends on the type of stress. We search for functional constraints that can explain fine tuning of gene expression under stress. For instance, under resource depletion, one may expect to find downregulation of the expression of large and abundant proteins, and upregulation of the expression of shorter proteins. Such a trend may be less evident if the stress does not compromise resource availability. In this work we analyze the existing data and find evidence that is consistent with economy in metabolism as an important pressure for shaping regulation of proteins synthesis in yeast stress response.