Estimating a multivariate treatment effect under a biased allocation rule

In a clinical trial with a biased allocation rule whereby all and only those patients at risk are given the new treatment, Robbins and Zhang (1989) derived an asymptotically normal and efficient estimator of the mean difference between the new and old treatments on those at risk. This paper with the use of a well known identity of Stein (1981) generalizes the result to the multivariate situation.

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