A Patient-Specific Computational Fluid Dynamics Model of the Left Atrium in Atrial Fibrillation: Development and Initial Evaluation

Atrial fibrillation (AF) is associated to a five-fold increase in the risk of stroke and AF strokes are especially severe. Stroke risk is connected to several AF related morphological and functional remodeling mechanisms which favor blood stasis and clot formation inside the left atrium. The goal of this study was therefore to develop a patient-specific computational fluid dynamics model of the left atrium which could quantify the hemodynamic implications of atrial fibrillation on a patient-specific basis. Hereto, dynamic patient-specific CT imaging was used to derive the 3D anatomical model of the left atrium by applying a specifically designed image segmentation algorithm. The computational model consisted in a fluid governed by the incompressible Navier-Stokes equations written in the Arbitrary Lagrangian Eulerian (ALE) frame of reference. In this paper, we present the developed model as well as its application to two AF patients. These initial results confirmed that morphological and functional remodeling processes associated to AF effectively reduce blood washout in the left atrium, thereby increasing the risk of clot formation. Our analysis is a step forward towards improved patient-specific stroke risk stratification and therapy planning.