Partitioned EDGE devices for high throughput production of monodisperse emulsion droplets with two distinct sizes.

We present a novel microfluidic EDGE (Edge based Droplet GEneration) device with regularly spaced micron-sized partitions, which is aimed at upscaling of o/w emulsion preparation. By this means, remarkably higher pressure stability was obtained, and two orders of magnitude higher droplet formation frequency was achieved compared to regular EDGE devices. Interestingly, we observed two different monodisperse droplet formation regimes for plateaus that were 2 micrometres in height, and to the best of our knowledge, no other microfluidic device has this ability. The average diameters of the droplets were 9 and 28 μm, both with a coefficient of variation (CV) below 5%. Based on the experimental throughput and a plausible mass parallelization scenario, the amount of hexadecane that can be emulsified is estimated to be between 6 and 25 m(3) m(-2) h(-1) depending on the required droplet size. With its high throughput potential and ability to produce uniform droplets of two different sizes, the partitioned EDGE device is promising for industrial emulsion production.

[1]  Mitsutoshi Nakajima,et al.  Effect of dispersed phase viscosity on maximum droplet generation frequency in microchannel emulsification using asymmetric straight-through channels , 2011 .

[2]  Piotr Garstecki,et al.  Formation of bubbles and droplets in parallel, coupled flow-focusing geometries. , 2008, Small.

[3]  R. Boom,et al.  Spontaneous droplet formation techniques for monodisperse emulsions preparation - Perspectives for food applications , 2011 .

[4]  R. Boom,et al.  Coalescence dynamics of surfactant-stabilized emulsions studied with microfluidics , 2012 .

[5]  Ryutaro Maeda,et al.  Straight-through microchannel devices for generating monodisperse emulsion droplets several microns in size , 2008 .

[6]  M. Nakajima,et al.  Comparison of stability of bovine serum albumin-stabilized emulsions prepared by microchannel emulsification and homogenization , 2006 .

[7]  Karin Schroën,et al.  Microfluidic emulsification devices: from micrometer insights to large-scale food emulsion production , 2015 .

[8]  Minoru Seki,et al.  Prediction of Droplet Diameter for Microchannel Emulsification: Prediction Model for Complicated Microchannel Geometries , 2004 .

[9]  R. Boom,et al.  A geometric model for the dynamics of microchannel emulsification. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[10]  Mitsutoshi Nakajima,et al.  Microchannel emulsification for mass production of uniform fine droplets: integration of microchannel arrays on a chip , 2010 .

[11]  Remko M. Boom,et al.  Status of cross-flow membrane emulsification and outlook for industrial application , 2004 .

[12]  Remko M. Boom,et al.  EDGE emulsification for food-grade dispersions. , 2010 .

[13]  Remko M Boom,et al.  Dynamic interfacial tension measurements with microfluidic Y-junctions. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[14]  R. Boom,et al.  The mechanism of droplet formation in microfluidic EDGE systems , 2010 .

[15]  R. V. D. Sman,et al.  Analysis of droplet formation and interactions during cross-flow membrane emulsification , 2002 .

[16]  Mitsutoshi Nakajima,et al.  Generation of highly uniform droplets using asymmetric microchannels fabricated on a single crystal silicon plate: Effect of emulsifier and oil types , 2008 .

[17]  Karin Schroën,et al.  Parallelized edge-based droplet generation (EDGE) devices. , 2009, Lab on a chip.

[18]  H. Fessi,et al.  The membrane emulsification process: a review , 2004 .

[19]  Craig A. Simmons,et al.  Simultaneous generation of droplets with different dimensions in parallel integrated microfluidic droplet generators. , 2008, Soft matter.

[20]  R. Boom,et al.  Preparation of monodispersed oil-in-water emulsions through semi-metal microfluidic EDGE systems , 2013 .

[21]  Remko M. Boom,et al.  Simultaneous formation of many droplets in a single microfluidic droplet formation unit , 2009 .

[22]  Mitsutoshi Nakajima,et al.  CFD analysis of microchannel emulsification: Droplet generation process and size effect of asymmetric straight flow-through microchannels , 2011 .

[23]  Yuji Kikuchi,et al.  Regular-sized cell creation in microchannel emulsification by visual microprocessing method , 1997 .

[24]  P. Tabeling,et al.  Producing droplets in parallel microfluidic systems. , 2006, Physical review. E, Statistical, nonlinear, and soft matter physics.

[25]  Mitsutoshi Nakajima,et al.  Effect of slot aspect ratio on droplet formation from silicon straight-through microchannels. , 2004, Journal of colloid and interface science.

[26]  Remko M. Boom,et al.  Effect of viscosities of dispersed and continuous phases in microchannel oil-in-water emulsification , 2010 .

[27]  Mitsutoshi Nakajima,et al.  Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices , 2012 .

[28]  R. Boom,et al.  Monodispersed water-in-oil emulsions prepared with semi-metal microfluidic EDGE systems , 2013 .

[29]  R. Boom,et al.  Microchannel emulsification: from computational fluid dynamics to predictive analytical model. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[30]  R. Boom,et al.  Influence of membrane morphology on pore activation in membrane emulsification , 2003 .

[31]  F. Chollet,et al.  New regime of droplet generation in a T-shape microfluidic junction , 2013 .

[32]  H. Fujita,et al.  Silicon array of elongated through-holes for monodisperse emulsion droplets , 2002 .