hypoxia by HIF-1 Transcriptional regulation of vascular endothelial cell responses to

[1]  M. Dewhirst,et al.  Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. , 2004, Cancer cell.

[2]  J. Thyberg,et al.  Comparative Evaluation of FGF-2–, VEGF-A–, and VEGF-C–Induced Angiogenesis, Lymphangiogenesis, Vascular Fenestrations, and Permeability , 2004, Circulation research.

[3]  C. Sotiriou,et al.  Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene , 2004, British Journal of Cancer.

[4]  D. Fliser,et al.  Erythropoietin regulates endothelial progenitor cells. , 2004, Blood.

[5]  L. Poellinger,et al.  HIF-1 and hypoxic response: the plot thickens. , 2004, Current opinion in genetics & development.

[6]  K. Seta,et al.  Functional genomics approach to hypoxia signaling. , 2004, Journal of applied physiology.

[7]  W. Aird,et al.  Thrombin and Phenotypic Modulation of the Endothelium , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[8]  Brian Keith,et al.  Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation , 2003, Molecular and Cellular Biology.

[9]  Kiichi Hirota,et al.  Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1 , 2003, Circulation research.

[10]  Dirk Koczan,et al.  Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells* , 2003, Journal of Biological Chemistry.

[11]  Hugh R. Brady,et al.  The Role of HIF-1α in Transcriptional Regulation of the Proximal Tubular Epithelial Cell Response to Hypoxia* , 2003, Journal of Biological Chemistry.

[12]  Seng H. Cheng,et al.  Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors , 2003, Circulation research.

[13]  K. Kitada,et al.  Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231. , 2003, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  A. Giaccia,et al.  HIF-1 as a target for drug development , 2003, Nature Reviews Drug Discovery.

[15]  G. Semenza.  Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[16]  M. Gassmann,et al.  Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells , 2003, Molecular and Cellular Biology.

[17]  H. Moch,et al.  Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL , 2003, Nature.

[18]  R. Altman,et al.  Investigating hypoxic tumor physiology through gene expression patterns , 2003, Oncogene.

[19]  K. Kivirikko,et al.  Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor* , 2003, Journal of Biological Chemistry.

[20]  C. Heeschen,et al.  Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. , 2003, Blood.

[21]  Sang Chul Park,et al.  Analysis of the effect of aging on the response to hypoxia by cDNA microarray , 2003, Mechanisms of Ageing and Development.

[22]  P. Carmeliet.  Angiogenesis in health and disease , 2003, Nature Medicine.

[23]  P. Ratcliffe,et al.  Regulation of angiogenesis by hypoxia: role of the HIF system , 2003, Nature Medicine.

[24]  Chi V. Dang,et al.  A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[25]  J. Klco,et al.  Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways. , 2003, Molecular cancer research : MCR.

[26]  T. Noll,et al.  Signaling of hypoxia‐induced autonomous proliferation of endothelial cells , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  R. Rickert,et al.  Hypoxia-Inducible Factor 1 (cid:2) Is Essential for Cell Cycle Arrest during Hypoxia , 2002 .

[28]  R. Johnson,et al.  Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. , 2003, Gene expression.

[29]  Hao Wu,et al.  MAANOVA: A Software Package for the Analysis of Spotted cDNA Microarray Experiments , 2003 .

[30]  Mircea Ivan,et al.  Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. McKnight,et al.  A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF , 2001, Science.

[32]  Michael I. Wilson,et al.  C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.

[33]  S. White,et al.  HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[34]  G. Semenza,et al.  Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. , 2001, Trends in molecular medicine.

[35]  J. Alam,et al.  Gene microarray analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells. , 2001, International journal of oncology.

[36]  M. Ivan,et al.  HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing , 2001, Science.

[37]  Michael I. Wilson,et al.  Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.

[38]  A. Harris,et al.  Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling , 2000, Oncogene.

[39]  V. V. van Hinsbergh,et al.  Urokinase receptor expression on human microvascular endothelial cells is increased by hypoxia: implications for capillary-like tube formation in a fibrin matrix. , 2000, Blood.

[40]  F. Peale,et al.  Gene expression profiling in an in vitro model of angiogenesis. , 2000, The American journal of pathology.

[41]  N. Voelkel,et al.  Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. , 1999, The Journal of clinical investigation.

[42]  C. Wykoff,et al.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.

[43]  G. Semenza,et al.  Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. , 1999, Developmental biology.

[44]  Yuichi Makino,et al.  Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway* , 1999, The Journal of Biological Chemistry.

[45]  P. Carmeliet,et al.  Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998) , 1998 .

[46]  L. Huang,et al.  Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway , 1998 .

[47]  Jessica Lo,et al.  HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .

[48]  T. E. Fitzpatrick,et al.  Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway. , 1998, Blood.

[49]  M. Gassmann,et al.  Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. , 1998, Genes & development.

[50]  J. Caro,et al.  Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. , 1997, The Journal of biological chemistry.

[51]  G. Semenza,et al.  Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. , 1996, The American journal of physiology.

[52]  G. Semenza,et al.  Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.

[53]  G. Semenza,et al.  Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1* , 1996, The Journal of Biological Chemistry.

[54]  G. Semenza,et al.  Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. , 1995, Proceedings of the National Academy of Sciences of the United States of America.