Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

[1]  R. D. Fisher,et al.  HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein , 2003, The Journal of cell biology.

[2]  S. Emr,et al.  Vps27 recruits ESCRT machinery to endosomes during MVB sorting , 2003, The Journal of cell biology.

[3]  A. Brech,et al.  Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes , 2003, The Journal of cell biology.

[4]  Rick A. Rogers,et al.  Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis* , 2003, Journal of Biological Chemistry.

[5]  A. Bean,et al.  Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex , 2003, The Journal of cell biology.

[6]  Yosef Yarden,et al.  Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation* , 2003, Journal of Biological Chemistry.

[7]  Y. Yarden,et al.  c-Cbl is a critical modulator of the Ron tyrosine kinase receptor , 2003, Oncogene.

[8]  Stanley N Cohen,et al.  TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[9]  K. Hofmann,et al.  When ubiquitin meets ubiquitin receptors: a signalling connection , 2003, Nature Reviews Molecular Cell Biology.

[10]  Morag Park,et al.  Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. , 2003, Cancer cell.

[11]  W. Salerno,et al.  Solution Structure of a CUE-Ubiquitin Complex Reveals a Conserved Mode of Ubiquitin Binding , 2003, Cell.

[12]  W. Cavenee,et al.  Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  H. Stenmark,et al.  STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes* , 2003, The Journal of Biological Chemistry.

[14]  Ivan Dikic,et al.  Negative receptor signalling. , 2003, Current opinion in cell biology.

[15]  Xuejun Jiang,et al.  Grb2 regulates internalization of EGF receptors through clathrin-coated pits. , 2003, Molecular biology of the cell.

[16]  Y. Yarden,et al.  Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Y. Yarden,et al.  The role of ubiquitylation in signaling by growth factors: implications to cancer. , 2003, Seminars in cancer biology.

[18]  W. Sundquist,et al.  Mechanisms of enveloped RNA virus budding. , 2002, Trends in cell biology.

[19]  S. Emr,et al.  Receptor downregulation and multivesicular-body sorting , 2002, Nature Reviews Molecular Cell Biology.

[20]  D. Birnbaum,et al.  Interaction between Two Ubiquitin-Protein Isopeptide Ligases of Different Classes, CBLC and AIP4/ITCH* , 2002, The Journal of Biological Chemistry.

[21]  Y. Yarden,et al.  Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4 , 2002, Traffic.

[22]  L. Neckers,et al.  Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Boon Chuan Low,et al.  Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling , 2002, The EMBO journal.

[24]  I. Dikic,et al.  Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Cowburn,et al.  A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. , 2002, Biochemical and biophysical research communications.

[26]  S. Lemeer,et al.  A Ubiquitin-interacting Motif (UIM) Is Essential for Eps15 and Eps15R Ubiquitination* , 2002, The Journal of Biological Chemistry.

[27]  F. Chou,et al.  Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas , 2002, Oncogene.

[28]  W. Sundquist,et al.  Structure and functional interactions of the Tsg101 UEV domain , 2002, The EMBO journal.

[29]  I. Lax,et al.  FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Madura The Ubiquitin-Associated (UBA) Domain: On the Path from Prudence to Prurience , 2002, Cell cycle.

[31]  P. Woodman,et al.  Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates , 2002, The Journal of cell biology.

[32]  Pier Paolo Di Fiore,et al.  A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins , 2002, Nature.

[33]  I. Dikic,et al.  Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors , 2002, Nature.

[34]  Giorgio F. Gilestro,et al.  The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met , 2002, Nature.

[35]  L. E. Johannessen,et al.  Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies , 2002, The Journal of cell biology.

[36]  K. Wilhelmsen,et al.  C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus , 2002, Oncogene.

[37]  Linyi Chen,et al.  Ubiquitin‐Independent Entry into the Yeast Recycling Pathway , 2002, Traffic.

[38]  H. Bellen,et al.  Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila , 2002, Cell.

[39]  J. Benovic,et al.  Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting* , 2001, The Journal of Biological Chemistry.

[40]  Wesley I. Sundquist,et al.  Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding , 2001, Cell.

[41]  A. Tsygankov,et al.  Beyond the RING: CBL proteins as multivalent adapters , 2001, Oncogene.

[42]  A. Aiyar,et al.  Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[43]  R. Baron,et al.  Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins* , 2001, The Journal of Biological Chemistry.

[44]  S. Emr,et al.  Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I , 2001, Cell.

[45]  Y. Yarden,et al.  Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex* , 2001, The Journal of Biological Chemistry.

[46]  L. Hicke,et al.  Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis* , 2001, The Journal of Biological Chemistry.

[47]  V. Rybin,et al.  Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins. , 2001, Journal of molecular biology.

[48]  T. Hunter,et al.  Oncogenic kinase signalling , 2001, Nature.

[49]  P. Woodman,et al.  TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes* , 2001, The Journal of Biological Chemistry.

[50]  W. Langdon,et al.  Cbl: many adaptations to regulate protein tyrosine kinases , 2001, Nature Reviews Molecular Cell Biology.

[51]  M. Komada,et al.  Hrs and hbp: possible regulators of endocytosis and exocytosis. , 2001, Biochemical and biophysical research communications.

[52]  Xiaolong Wei,et al.  Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor* , 2001, The Journal of Biological Chemistry.

[53]  Y. Yarden,et al.  Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.

[54]  H. Steven Wiley,et al.  Regulation of Receptor Tyrosine Kinase Signaling by Endocytic Trafficking , 2001, Traffic.

[55]  K. Miyazawa,et al.  A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP* , 2000, The Journal of Biological Chemistry.

[56]  A. Ciechanover,et al.  The ubiquitin system , 2000, Nature Medicine.

[57]  N. Kitamura,et al.  Early Endosomal Localization of Hrs Requires a Sequence within the Proline- and Glutamine-rich Region but Not the FYVE Finger* , 2000, The Journal of Biological Chemistry.

[58]  Y. Yarden,et al.  Threonine Phosphorylation Diverts Internalized Epidermal Growth Factor Receptors from a Degradative Pathway to the Recycling Endosome* , 2000, The Journal of Biological Chemistry.

[59]  C. Tacchetti,et al.  Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis , 2000, The Journal of cell biology.

[60]  R. Rottapel,et al.  Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation* , 2000, The Journal of Biological Chemistry.

[61]  L. E. Johannessen,et al.  Polyubiquitination of the Epidermal Growth Factor Receptor Occurs at the Plasma Membrane upon Ligand-induced Activation* , 2000, The Journal of Biological Chemistry.

[62]  S. Emr,et al.  Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking , 2000, Traffic.

[63]  N. Kitamura,et al.  A Hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors , 2000, Genes to cells : devoted to molecular & cellular mechanisms.

[64]  B. Kay,et al.  The EH network. , 1999, Experimental cell research.

[65]  R. Baron,et al.  Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7* , 1999, The Journal of Biological Chemistry.

[66]  S. Mundell,et al.  Trafficking of the HIV Coreceptor CXCR4 , 1999, The Journal of Biological Chemistry.

[67]  R. Baron,et al.  Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl , 1999, The Journal of Biological Chemistry.

[68]  T. Hunter,et al.  The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.

[69]  D. Rotin,et al.  mGrb10 Interacts with Nedd4* , 1999, The Journal of Biological Chemistry.

[70]  Y. Yarden,et al.  The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.

[71]  P. P. D. Fiore,et al.  Endocytosis and mitogenic signaling. , 1999 .

[72]  R. Heilker,et al.  Recognition of sorting signals by clathrin adaptors , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[73]  Y. Yarden,et al.  The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[74]  B. André,et al.  The yeast Npi1/Rsp5 ubiquitin ligase lacking its N-terminal C2 domain is competent for ubiquitination but not for subsequent endocytosis of the gap1 permease. , 1999, Biochemical and biophysical research communications.

[75]  H. Wiley,et al.  ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors* , 1999, The Journal of Biological Chemistry.

[76]  F. Brodsky,et al.  EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake , 1999, Cell.

[77]  H. Sakamoto,et al.  APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis , 1999, Oncogene.

[78]  Shyr‐Yi Lin,et al.  Multiple truncated transcripts of TSG101 in gastrointestinal cancers , 1998, Journal of gastroenterology and hepatology.

[79]  T. Stevens,et al.  Multiple sorting pathways between the late Golgi and the vacuole in yeast. , 1998, Biochimica et biophysica acta.

[80]  B. Druker,et al.  The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[81]  A. Schwartz,et al.  Di-leucine-mediated Internalization of Ligand by a Truncated Growth Hormone Receptor Is Independent of the Ubiquitin Conjugation System* , 1998, The Journal of Biological Chemistry.

[82]  S. Schmid,et al.  AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis , 1998, The Journal of cell biology.

[83]  N. Tanaka,et al.  Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule , 1997, The Journal of Biological Chemistry.

[84]  W. Langdon,et al.  Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl , 1997, Oncogene.

[85]  Stanley N Cohen,et al.  Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours , 1997, Oncogene.

[86]  A. Verkleij,et al.  Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin , 1997, The Journal of cell biology.

[87]  Sakae Tanaka,et al.  c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption , 1996, Nature.

[88]  Rein Aasland,et al.  Endosomal Localization of the Autoantigen EEA1 Is Mediated by a Zinc-binding FYVE Finger* , 1996, The Journal of Biological Chemistry.

[89]  Stanley N Cohen,et al.  tsg101: A Novel Tumor Susceptibility Gene Isolated by Controlled Homozygous Functional Knockout of Allelic Loci in Mammalian Cells , 1996, Cell.

[90]  P. De Camilli,et al.  Phosphoinositides as Regulators in Membrane Traffic , 1996, Science.

[91]  Howard Riezman,et al.  Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis , 1996, Cell.

[92]  H. Wiley,et al.  Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[93]  D. McCance,et al.  The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes , 1995, Journal of virology.

[94]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[95]  H. Kung,et al.  Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R , 1991, Journal of virology.

[96]  A. Ullrich,et al.  Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body , 1990, Cell.

[97]  J. Welsh,et al.  Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. , 1990, Science.

[98]  S. Klinken,et al.  v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. , 1989, Proceedings of the National Academy of Sciences of the United States of America.