Duration and Influencing Factors of Postoperative Urinary Incontinence after Robot-Assisted Radical Prostatectomy in a Japanese Community Hospital: A Single-Center Retrospective Cohort Study

Objectives: Post-operative urinary incontinence (PUI) after robotic-assisted radical prostatectomy (RARP) is an important complication; PUI occurs immediately after postoperative urethral catheter removal, and, although approximately 90% of patients improve within one year after surgery, it can significantly worsen their quality of life. However, information is lacking on its nature in community hospital settings, particularly in Asian countries. The purposes of this study were to investigate the time required to recover from PUI after RARP and to identify its associated factors in a Japanese community hospital. Methods: Data were extracted from the medical records of 214 men with prostate cancer who underwent RARP from 2019 to 2021. We then calculated the number of days elapsed from the surgery to the initial outpatient visit confirming PUI recovery among the patients. We estimated the PUI recovery rate using the Kaplan–Meier product limit method and evaluated associated factors using the multivariable Cox proportional hazards model. Results: The PUI recovery rates were 5.7%, 23.4%, 64.6%, and 93.3% at 30, 90, 180, and 365 days following RARP, respectively. After an adjustment, those with preoperative urinary incontinence experienced significantly slower PUI recovery than their counterparts, while those with bilateral nerve sparing experienced recovery significantly sooner than those with no nerve sparing. Conclusion: Most PUI improved within one year, but a proportion of those experiencing recovery before 90 days was smaller than previously reported.

[1]  M. Oya,et al.  Predictors of urinary function recovery after laparoscopic and robot-assisted radical prostatectomy , 2022, International braz j urol : official journal of the Brazilian Society of Urology.

[2]  Christian Wagner,et al.  Impact of obesity on perioperative, functional and oncological outcomes after robotic-assisted radical prostatectomy in a high-volume center , 2022, World Journal of Urology.

[3]  K. Amano,et al.  Changes in quality of life and lower urinary tract symptoms over time in cancer patients after a total prostatectomy: systematic review and meta-analysis , 2021, Supportive Care in Cancer.

[4]  R. Newton,et al.  Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy – a systematic review and meta-analysis , 2021, Disability and rehabilitation.

[5]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[6]  H. G. van der Poel,et al.  EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. , 2020, European urology.

[7]  H. Ahn,et al.  Integrity of the Urethral Sphincter Complex, Nerve-sparing, and Long-term Continence Status after Robotic-assisted Radical Prostatectomy. , 2019, European urology focus.

[8]  Yuhong Yuan,et al.  The benefits and harms of different extents of lymph node dissection during radical prostatectomy for prostate cancer: A systematic review , 2018 .

[9]  Dapeng Wu,et al.  Robot-Assisted Radical Prostatectomy Is More Beneficial for Prostate Cancer Patients: A System Review and Meta-Analysis , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[10]  I-Hung Shao,et al.  Predictors of short-term and long-term incontinence after robot-assisted radical prostatectomy , 2017, The Journal of international medical research.

[11]  A. Takenaka,et al.  A prognostic model for predicting urinary incontinence after robot‐assisted radical prostatectomy , 2017, The international journal of medical robotics + computer assisted surgery : MRCAS.

[12]  Manish I. Patel,et al.  Preoperative Pelvic Floor Muscle Exercise and Postprostatectomy Incontinence: A Systematic Review and Meta-analysis. , 2016, European urology.

[13]  F. Shishido,et al.  Association between postoperative pelvic anatomic features on magnetic resonance imaging and lower tract urinary symptoms after radical prostatectomy. , 2014, Urology.

[14]  H. G. van der Poel,et al.  Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy. , 2012, European urology.

[15]  Jens Hansen,et al.  Perioperative outcomes of robot-assisted radical prostatectomy compared with open radical prostatectomy: results from the nationwide inpatient sample. , 2012, European urology.

[16]  P. Scardino,et al.  Recovery of urinary function after radical prostatectomy: predictors of urinary function on preoperative prostate magnetic resonance imaging. , 2011, The Journal of urology.

[17]  A. Haese*,et al.  Full functional-length urethral sphincter preservation during radical prostatectomy. , 2011, European urology.

[18]  V. Ficarra,et al.  Evaluating urinary continence and preoperative predictors of urinary continence after robot assisted laparoscopic radical prostatectomy. , 2010, The Journal of urology.

[19]  H. Hricak,et al.  Recovery of urinary continence after radical prostatectomy: association with urethral length and urethral fibrosis measured by preoperative and postoperative endorectal magnetic resonance imaging. , 2009, European urology.

[20]  Michel Bolla,et al.  [EAU guidelines on prostate cancer]. , 2009, Actas urologicas espanolas.