Detection of early behavioral markers of Huntington's disease in R6/2 mice employing an automated social home cage

[1]  W. I. Welker,et al.  “Free” versus “Forced” Exploration of a Novel Situation by Rats , 1957 .

[2]  S. Zola-Morgan,et al.  Comparative neuropsychology and Korsakoff's syndrome. III—Delayed response, delayed alternation and DRL performance , 1982, Neuropsychologia.

[3]  R. Wilson,et al.  Memory failure in Huntington's disease. , 1987, Journal of clinical and experimental neuropsychology.

[4]  Impaired learning of a motor skill in patients with Huntington's disease. , 1988, Behavioral neuroscience.

[5]  D. Salmon,et al.  Impaired learning of a motor skill in patients with Huntington's disease. , 1988, Behavioral neuroscience.

[6]  M. Nissen,et al.  Procedural learning is impaired in Huntington's disease: Evidence from the serial reaction time task , 1991, Neuropsychologia.

[7]  Manish S. Shah,et al.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.

[8]  M. Morris Dementia and cognitive changes in Huntington's disease. , 1995, Advances in neurology.

[9]  Virginia E. Papaioannou,et al.  Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue , 1995, Nature Genetics.

[10]  C. Marsden,et al.  Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[11]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[12]  Jacqueline K. White,et al.  Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion , 1997, Nature Genetics.

[13]  L. Bäckman,et al.  Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes. , 1997, Brain : a journal of neurology.

[14]  J. Penney,et al.  Huntingtin localization in brains of normal and Huntington's disease patients , 1997, Annals of neurology.

[15]  J. Gabrieli,et al.  Intact mirror-tracing and impaired rotary-pursuit skill learning in patients with Huntington's disease: evidence for dissociable memory systems in skill learning. , 1997, Neuropsychology.

[16]  T. Robbins,et al.  Discrimination, reversal, and shift learning in Huntington’s disease: mechanisms of impaired response selection , 1999, Neuropsychologia.

[17]  M. Hurlbert,et al.  Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. , 1999, Diabetes.

[18]  A. Morton,et al.  Selective Discrimination Learning Impairments in Mice Expressing the Human Huntington's Disease Mutation , 1999, The Journal of Neuroscience.

[19]  Stephen B. Dunnett,et al.  Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation , 1999, The Journal of Neuroscience.

[20]  Jane S. Paulsen,et al.  The disparate effects of Alzheimer's disease and Huntington's disease on semantic memory. , 1999, Neuropsychology.

[21]  S B Dunnett,et al.  Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation , 2000, The Journal of Neuroscience.

[22]  T. Robbins,et al.  Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits. , 2000, Brain : a journal of neurology.

[23]  R. D Rogers,et al.  Impaired planning but intact decision making in early Huntington’s disease: implications for specific fronto-striatal pathology , 2000, Neuropsychologia.

[24]  D. Rigamonti,et al.  Huntingtin's Neuroprotective Activity Occurs via Inhibition of Procaspase-9 Processing* , 2001, The Journal of Biological Chemistry.

[25]  J. Schiefer,et al.  Evaluation of R6/2 HD transgenic mice for therapeutic studies in Huntington's disease: behavioral testing and impact of diabetes mellitus , 2001, Behavioural Brain Research.

[26]  Ole A. Andreassen,et al.  Therapeutic Effects of Coenzyme Q10 and Remacemide in Transgenic Mouse Models of Huntington's Disease , 2002, The Journal of Neuroscience.

[27]  Klaus Schmidtke,et al.  Cognitive procedural learning in patients with fronto-striatal lesions. , 2002, Learning & memory.

[28]  D. Neary,et al.  Psychomotor, Executive, and Memory Function in Preclinical Huntington's Disease , 2002, Journal of clinical and experimental neuropsychology.

[29]  Stephen Monsell,et al.  Task-Set Switching Deficits in Early-Stage Huntington's Disease: Implications for Basal Ganglia Function , 2003, Journal of Cognitive Neuroscience.

[30]  Cathryn M Lewis,et al.  Standardization and statistical approaches to therapeutic trials in the R6/2 mouse , 2003, Brain Research Bulletin.

[31]  V. Bolivar,et al.  Exploratory activity and fear conditioning abnormalities develop early in R6/2 Huntington's disease transgenic mice. , 2003, Behavioral Neuroscience.

[32]  Y. Yoshida,et al.  Oropharyngeal dysphagia in a case of Huntington's disease. , 2004, Auris, nasus, larynx.

[33]  Pascal O. Zinn,et al.  Automated behavioral analysis of mice using INTELLICAGE: inter-laboratory comparisons and validation with exploratory behavior and spatial learning , 2005 .

[34]  A. Vyssotski,et al.  A comparison of wild-caught wood mice and bank voles in the Intellicage: assessing exploration, daily activity patterns and place learning paradigms , 2005, Behavioural Brain Research.

[35]  N. Nukina,et al.  Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine‐EGFP fluorescent aggregates , 2005, Journal of neurochemistry.

[36]  M. Chesselet,et al.  Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing , 2005, Neurobiology of Disease.

[37]  A. Morton,et al.  A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease , 2005, The European journal of neuroscience.

[38]  Ewelina Knapska,et al.  Differential involvement of the central amygdala in appetitive versus aversive learning. , 2006, Learning & memory.

[39]  S. Humbert,et al.  Huntington’s disease: from huntingtin function and dysfunction to therapeutic strategies , 2006, Cellular and Molecular Life Sciences CMLS.

[40]  V. Bolivar,et al.  Habituation in rodents: A review of behavior, neurobiology, and genetics , 2006, Neuroscience & Biobehavioral Reviews.

[41]  S. Chanda,et al.  Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system , 2006, Nature Methods.

[42]  S. Dunnett,et al.  The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock‐in mouse model of Huntington's disease , 2007, The European journal of neuroscience.

[43]  S. Hersch,et al.  Drug targeting of dysregulated transcription in Huntington's disease , 2007, Progress in Neurobiology.

[44]  Jeffrey H Kordower,et al.  Animal models of Huntington's disease. , 2007, ILAR journal.

[45]  Andrew D. Steele,et al.  The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases , 2007, Proceedings of the National Academy of Sciences.

[46]  M. Scattoni,et al.  Behavioral and electrophysiological effects of the adenosine A2A receptor antagonist SCH 58261 in R6/2 Huntington’s disease mice , 2007, Neurobiology of Disease.

[47]  A. Young,et al.  A small-molecule therapeutic lead for Huntington's disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse , 2007, Proceedings of the National Academy of Sciences.

[48]  A. Reiner,et al.  Wild-type huntingtin plays a role in brain development and neuronal survival , 2007, Molecular Neurobiology.

[49]  J. Cha,et al.  Transcriptional signatures in Huntington's disease , 2007, Progress in Neurobiology.

[50]  T. Hökfelt,et al.  Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[51]  G. Rebec,et al.  Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease , 2007, Behavioural Brain Research.

[52]  Jaclyn I. Wamsteeker,et al.  Increased metabolism in the R6/2 mouse model of Huntington’s disease , 2008, Neurobiology of Disease.

[53]  D. Rubinsztein,et al.  Huntington's disease: from pathology and genetics to potential therapies. , 2008, The Biochemical journal.

[54]  R. Barker,et al.  Increased thirst and drinking in Huntington's disease and the R6/2 mouse , 2008, Brain Research Bulletin.

[55]  D. Sengelaub,et al.  Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse , 2008, Neuroscience.

[56]  H. Diana Rosas,et al.  Neuroprotection for Huntington’s disease: Ready, set, slow , 2008, Neurotherapeutics.