Embryonic infection with the endogenous avian leukosis virus Rous-associated virus-0 alters responses to exogenous avian leukosis virus infection

We inoculated susceptible chicken embryos with the endogenous avian leukosis virus Rous-associated virus-0 (RAV-0) on day 6 of incubation. At 1 week after hatching, RAV-0-infected and control chickens were inoculated with either RAV-1 or RAV-2, exogenous viruses belonging to subgroups A and B, respectively. The chickens injected with RAV-0 as embryos remained viremic with exogenous virus longer and either failed to develop type-specific humoral immunity to exogenous virus or developed it later than the control chickens not inoculated with RAV-0. The RAV-0-injected chickens also developed neoplasms at a much higher frequency than did the control chickens. We suggest that the lower immune responses of the RAV-0-injected chickens were due to an immunological tolerance to envelope group-specific glycoproteins shared among endogenous and exogenous viruses.

[1]  E. Smith,et al.  Selective shedding and congenital transmission of endogenous avian leukosis viruses , 1986, Journal of virology.

[2]  E. Smith,et al.  Endogenous viral genes in a slow-feathering line of White Leghorn chickens. , 1986, Avian pathology : journal of the W.V.P.A.

[3]  J. Coffin,et al.  Molecular basis of host range variation in avian retroviruses , 1985, Journal of virology.

[4]  E. Smith,et al.  Influence of endogenous viral (ev) gene expression and strain of exogenous avian leukosis virus (ALV) on mortality and ALV infection and shedding in chickens. , 1984, Avian diseases.

[5]  V. A. Garwood,et al.  Influence of sex-linked feathering phenotypes of parents and progeny upon lymphoid leukosis virus infection status and egg production. , 1984, Poultry science.

[6]  E. Smith,et al.  Effect of endogenous leukosis virus genes on response to infection with avian leukosis and reticuloendotheliosis viruses. , 1982, Avian diseases.

[7]  J. M. Sharma,et al.  Resistance to Marek's disease at hatching in chickens vaccinated as embryos with the turkey herpesvirus. , 1982, Avian diseases.

[8]  L. Crittenden.  Exogenous and endogenous leukosis virus genes--a review. , 1981, Avian pathology : journal of the W.V.P.A.

[9]  D. L. Harris,et al.  Lymphoid leukosis virus infection: effects on production and mortality and consequences in selection for high egg production. , 1980, Poultry science.

[10]  S. Astrin,et al.  Ev 2, a genetic locus containing structural genes for endogenous virus, codes for Rous-associated virus type 0 produced by line 72 chickens , 1980, Journal of virology.

[11]  W. S. Hayward,et al.  Endogenous viral genes are non-essential in the chicken , 1979, Nature.

[12]  A. Fadly,et al.  Low incidence of lymphoid tumors in chickens continuously producing endogenous virus. , 1979, Avian diseases.

[13]  L. Crittenden,et al.  Assays for Endogenous and Exogenous Lymphoid Leukosis Viruses and Chick Helper Factor with RSV(−) Cell Lines , 1979, Infection and immunity.

[14]  M. Halpern,et al.  Immunogenicity of the envelope glycoprotein of avian sarcoma virus. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[15]  E. Smith,et al.  Genetic control of RAV-O production in chickens. , 1977, Virology.

[16]  H. Hanafusa.  Avian RNA Tumor Viruses , 1975 .

[17]  R. Weiss,et al.  Host gene control of endogenous avian leukosis virus production. , 1974, Virology.

[18]  P. Vogt,et al.  An avian leukosis virus related to RSV(O): properties and evidence for helper activity. , 1971, Virology.

[19]  P. Vogt,et al.  Patterns of viral interference in the avian leukosis and sarcoma complex. , 1966, Virology.

[20]  P. Vogt,et al.  Immunological relationships among envelope antigens of avian tumor viruses. , 1966, Virology.

[21]  H. Rubin,et al.  Tolerance and immunity in chickens after congenital and contact infection with an avian leukosis virus. , 1962, Virology.