Drugs, leads, and drug-likeness: an analysis of some recently launched drugs.
暂无分享,去创建一个
[1] Eugen Reichel,et al. 1. A - C , 1909 .
[2] S. Cohen,et al. A new probe for heterogeneity in muscarinic receptors: 2-methyl-spiro-(1, 3-dioxolane-4, 3')-quinuclidine. , 1976, European journal of pharmacology.
[3] H. Hofmeister,et al. Synthesis of Spirorenone—A Novel Highly Active Aldosterone Antagonist , 1982 .
[4] T. Mori,et al. Synthetic studies of vitamin D3 analogues. VIII. Synthesis of 22-oxavitamin D3 analogues. , 1986, Chemical & pharmaceutical bulletin.
[5] J. Flippen-Anderson,et al. Arteether, a new antimalarial drug: synthesis and antimalarial properties. , 1988, Journal of medicinal chemistry.
[6] D W Cushman,et al. Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines. , 1988, Journal of medicinal chemistry.
[7] P. Lombardi,et al. 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): a new irreversible aromatase inhibitor. , 1988, Journal of steroid biochemistry.
[8] M. Yasunami,et al. Synthesis and anti-ulcer activities of sodium alkylazulene sulfonates. , 1988, Chemical & pharmaceutical bulletin.
[9] K. Iwata,et al. In vitro and in vivo activities of piritetrate (M-732), a new antidermatophytic thiocarbamate , 1989, Antimicrobial Agents and Chemotherapy.
[10] M Gwilt,et al. Selective class III antiarrhythmic agents. 1 Bis(arylalkyl)amines. , 1990, Journal of medicinal chemistry.
[11] H. Sugano,et al. Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. , 1990, Journal of medicinal chemistry.
[12] Aalt Bast,et al. Comprehensive medicinal chemistry , 1991 .
[13] Anne W. Schmidt,et al. 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents. , 1991, Journal of medicinal chemistry.
[14] D. Gurwitz,et al. (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. , 1991, The Journal of pharmacology and experimental therapeutics.
[15] J. Gobert,et al. ucb L059, a novel anti-convulsant drug: pharmacological profile in animals. , 1992, European journal of pharmacology.
[16] A. Brown,et al. (+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor. , 1993, Journal of medicinal chemistry.
[17] H. Ohnishi,et al. Gastric antisecretory effect of FRG-8813, a new histamine H2 receptor antagonist, in rats and dogs. , 1993, European journal of pharmacology.
[18] D. Mangelsdorf,et al. Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. , 1994, Journal of medicinal chemistry.
[19] K. Jaeggi,et al. Preclinical pharmacology of CGP 42′446, a new, potent, heterocyclic bisphosphonate compound , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[20] N. Kalkkinen,et al. Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study. , 1994, The Journal of biological chemistry.
[21] L Zhang,et al. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. , 1994, Journal of medicinal chemistry.
[22] M. Yoshigi,et al. Succinimide derivatives. II. Synthesis and antipsychotic activity of N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cis- cyclohexanedicarboximide (SM-9018) and related compounds. , 1995, Chemical & pharmaceutical bulletin.
[23] S. J. Brickner,et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. , 1996, Journal of medicinal chemistry.
[24] Anne W. Schmidt,et al. 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. , 1996, Journal of medicinal chemistry.
[25] Ajay,et al. Can we learn to distinguish between "drug-like" and "nondrug-like" molecules? , 1998, Journal of medicinal chemistry.
[26] Dale J. Kempf,et al. ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease , 1998, Antimicrobial Agents and Chemotherapy.
[27] H. Kubinyi,et al. A scoring scheme for discriminating between drugs and nondrugs. , 1998, Journal of medicinal chemistry.
[28] G. Bemis,et al. Properties of known drugs. 2. Side chains. , 1999, Journal of medicinal chemistry.
[29] Tudor I. Oprea,et al. The Design of Leadlike Combinatorial Libraries. , 1999, Angewandte Chemie.
[30] J. Palacios,et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. , 2000, European journal of pharmacology.
[31] Pickett,et al. Computational methods for the prediction of 'drug-likeness' , 2000, Drug discovery today.
[32] Tudor I. Oprea,et al. Is There a Difference between Leads and Drugs? A Historical Perspective , 2001, J. Chem. Inf. Comput. Sci..
[33] I. Muegge,et al. Simple selection criteria for drug-like chemical matter. , 2001, Journal of medicinal chemistry.