Using SemRep to Label Semantic Relations Extracted from Clinical Text

In this paper we examined the relationship between semantic relatedness among medical concepts found in clinical reports and biomedical literature. Our objective is to determine whether relations between medical concepts identified from Medline abstracts may be used to inform us as to the nature of the association between medical concepts that appear to be closely related based on their distribution in clinical reports. We used a corpus of 800k inpatient clinical notes as a source of data for determining the strength of association between medical concepts and SemRep database as a source of labeled relations extracted from Medline abstracts. The same pair of medical concepts may be found with more than one predicate type in the SemRep database but often with different frequencies. Our analysis shows that predicate type frequency information obtained from the SemRep database appears to be helpful for labeling semantic relations obtained with measures of semantic relatedness and similarity.

[1]  Ted Pedersen,et al.  UMLS-Interface and UMLS-Similarity : Open Source Software for Measuring Paths and Semantic Similarity , 2009, AMIA.

[2]  Marcelo Fiszman,et al.  Extracting Semantic Predications from Medline Citations for Pharmacogenomics , 2006, Pacific Symposium on Biocomputing.

[3]  Michael E. Lesk,et al.  Automatic sense disambiguation using machine readable dictionaries: how to tell a pine cone from an ice cream cone , 1986, SIGDOC '86.

[4]  Christiane Fellbaum,et al.  Combining Local Context and Wordnet Similarity for Word Sense Identification , 1998 .

[5]  Bridget T. McInnes,et al.  Evaluating measures of redundancy in clinical texts. , 2011, AMIA ... Annual Symposium proceedings. AMIA Symposium.

[6]  R. Nosofsky Attention, similarity, and the identification-categorization relationship. , 1986, Journal of experimental psychology. General.

[7]  Martha Palmer,et al.  Verb Semantics and Lexical Selection , 1994, ACL.

[8]  Carol Friedman,et al.  Exploiting Semantic Relations for Literature-Based Discovery , 2006, AMIA.

[9]  Martin Chodorow,et al.  Combining local context and wordnet similarity for word sense identification , 1998 .

[10]  Roy Rada,et al.  Development and application of a metric on semantic nets , 1989, IEEE Trans. Syst. Man Cybern..

[11]  Marcelo Fiszman,et al.  Graph-based methods for discovery browsing with semantic predications. , 2011, AMIA ... Annual Symposium proceedings. AMIA Symposium.

[12]  Ashwin Ram,et al.  Socio-Semantic Health Information Access , 2011, AAAI Spring Symposium: AI and Health Communication.

[13]  Terrence Adam,et al.  Semantic Similarity and Relatedness between Clinical Terms: An Experimental Study. , 2010, AMIA ... Annual Symposium proceedings. AMIA Symposium.

[14]  Deendayal Dinakarpandian,et al.  Finding disease similarity based on implicit semantic similarity , 2012, J. Biomed. Informatics.

[15]  Christiane Fellbaum,et al.  Lexical Chains as Representations of Context for the Detection and Correction of Malapropisms , 1998 .

[16]  Halil Kilicoglu,et al.  Medical Facts to Support Inferencing in Natural Language Processing , 2005, AMIA.

[17]  R. Nosofsky Attention, similarity, and the identification-categorization relationship. , 1986 .

[18]  Marcelo Fiszman,et al.  The interaction of domain knowledge and linguistic structure in natural language processing: interpreting hypernymic propositions in biomedical text , 2003, J. Biomed. Informatics.

[19]  Halil Kilicoglu,et al.  Abstraction Summarization for Managing the Biomedical Research Literature , 2004, HLT-NAACL 2004.

[20]  Lawrence Hunter,et al.  Coordination resolution in biomedical texts , 2011 .

[21]  Halil Kilicoglu,et al.  Semantic MEDLINE: A web application for managing the results of PubMed searches , 2008, SMBM 2008.

[22]  Alan R. Aronson,et al.  Effective mapping of biomedical text to the UMLS Metathesaurus: the MetaMap program , 2001, AMIA.

[23]  Ted Pedersen,et al.  Using WordNet-based Context Vectors to Estimate the Semantic Relatedness of Concepts , 2006 .

[24]  Bridget T. McInnes,et al.  Knowledge-based method for determining the meaning of ambiguous biomedical terms using information content measures of similarity. , 2011, AMIA ... Annual Symposium proceedings. AMIA Symposium.

[25]  Ted Pedersen,et al.  Semantic relatedness study using second order co-occurrence vectors computed from biomedical corpora, UMLS and WordNet , 2012, IHI '12.