Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb/III trial

[1]  M. Wahidi,et al.  Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy , 2019, Chest.

[2]  D. Rex,et al.  A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy. , 2018, Gastrointestinal endoscopy.

[3]  D. Riff,et al.  A phase IIb study comparing the safety and efficacy of remimazolam and midazolam in patients undergoing colonoscopy. , 2016, Gastrointestinal endoscopy.

[4]  D. Riff,et al.  A Phase IIa, Randomized, Double-Blind Study of Remimazolam (CNS 7056) Versus Midazolam for Sedation in Upper Gastrointestinal Endoscopy , 2015, Anesthesia and analgesia.

[5]  M. Worthington,et al.  A Phase Ib, Dose-Finding Study of Multiple Doses of Remimazolam (CNS 7056) in Volunteers Undergoing Colonoscopy , 2013, Anesthesia and analgesia.

[6]  T. Schnider,et al.  Context sensitive decrement times of remimazolam. , 2013, Anesthesia and analgesia.

[7]  R. Eckenhoff,et al.  Anesthetic drug development: Novel drugs and new approaches , 2013, Surgical neurology international.

[8]  Gavin Kilpatrick,et al.  A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part I. Safety, Efficacy, and Basic Pharmacokinetics , 2012, Anesthesia and analgesia.

[9]  Gavin Kilpatrick,et al.  A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation , 2012, Anesthesia and analgesia.

[10]  K. Olkkola,et al.  Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology , 2011, Pharmacological Reviews.

[11]  R. Upton,et al.  Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep. , 2010, British journal of anaesthesia.

[12]  J. R. Sneyd,et al.  New drugs and technologies, intravenous anaesthesia is on the move (again). , 2010, British journal of anaesthesia.

[13]  Gavin Kilpatrick,et al.  CNS 7056: A Novel Ultra–short-acting Benzodiazepine , 2007, Anesthesiology.

[14]  J. Johansen,et al.  Update on bispectral index monitoring. , 2006, Best practice & research. Clinical anaesthesiology.

[15]  M Danhof,et al.  Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam. , 1999, The Journal of pharmacology and experimental therapeutics.

[16]  Pharmaceutical Development.  INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE ICH HARMONISED TRIPARTITE GUIDELINE , 1998 .

[17]  J Norman,et al.  Propofol: clinical strategies for preventing the pain of injection , 1988, Anaesthesia.

[18]  R. Hetherington,et al.  A SIMPLE STUDY OF AWARENESS AND DREAMING DURING ANAESTHESIA , 1970 .