Economic Cost of Dengue in Puerto Rico

Dengue, endemic in Puerto Rico, reached a record high in 2010. To inform policy makers, we derived annual economic cost. We assessed direct and indirect costs of hospitalized and ambulatory dengue illness in 2010 dollars through surveillance data and interviews with 100 laboratory-confirmed dengue patients treated in 2008–2010. We corrected for underreporting by using setting-specific expansion factors. Work absenteeism because of a dengue episode exceeded the absenteeism for an episode of influenza or acute otitis media. From 2002 to 2010, the aggregate annual cost of dengue illness averaged $38.7 million, of which 70% was for adults (age 15+ years). Hospitalized patients accounted for 63% of the cost of dengue illness, and fatal cases represented an additional 17%. Households funded 48% of dengue illness cost, the government funded 24%, insurance funded 22%, and employers funded 7%. Including dengue surveillance and vector control activities, the overall annual cost of dengue was $46.45 million ($12.47 per capita).

[1]  J. Muñoz-Jordán,et al.  Description of a large island-wide outbreak of dengue in Puerto Rico, 2007. , 2009, The American journal of tropical medicine and hygiene.

[2]  A. Fauci,et al.  Dengue and hemorrhagic fever: a potential threat to public health in the United States. , 2008, JAMA.

[3]  M. Guzmán,et al.  Impacto económico de la epidemia de dengue 2 en Santiago de Cuba, 1997 , 2002 .

[4]  P. Singhasivanon,et al.  Dengue is a major global health problem. Foreword. , 2009, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[5]  L. Morris,et al.  Dengue fever in a Puerto Rican community. , 1967, American journal of epidemiology.

[6]  N. Valero,et al.  Impacto económico del dengue y del dengue hemorrágico en el Estado de Zulia, Venezuela, 1997-2003 , 2006 .

[7]  Y. Halasa,et al.  Economic cost of dengue public prevention activities in Puerto Rico. , 2010 .

[8]  A. Piperno,et al.  2003 , 2003, Intensive Care Medicine.

[9]  A David Paltiel,et al.  Economic costs of influenza-related work absenteeism. , 2003, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

[10]  G. Ruche,et al.  Increase in dengue fever imported from Côte d'Ivoire and West Africa to France , 2010 .

[11]  S. Halstead,et al.  Neutralization and antibody-dependent enhancement of dengue viruses. , 2003, Advances in virus research.

[12]  H. Nishiura Duration of short-lived cross-protective immunity against a clinical attack of dengue: A preliminary estimate , 2008 .

[13]  G. Clark,et al.  Community beliefs and practices about dengue in Puerto Rico. , 2009, Revista panamericana de salud publica = Pan American journal of public health.

[14]  J. Lang,et al.  Epidemiological and clinical observations on patients with dengue in Puerto Rico: results from the first year of enhanced surveillance--June 2005-May 2006. , 2008, The American journal of tropical medicine and hygiene.

[15]  D. Gubler Emerging vector-borne flavivirus diseases: are vaccines the solution? , 2011, Expert review of vaccines.

[16]  Alfonso Gúzman,et al.  Update on the global spread of dengue. , 2010, International journal of antimicrobial agents.

[17]  W. Gropp,et al.  Does increased aromatase activity in adipose fibroblasts cause low sexual desire in patients with HIV lipodystrophy? , 2002, Sexually transmitted infections.

[18]  Eva Harris,et al.  Global spread and persistence of dengue. , 2008, Annual review of microbiology.

[19]  D. Gubler,et al.  Community-based dengue prevention programs in Puerto Rico: impact on knowledge, behavior, and residential mosquito infestation. , 2002, The American journal of tropical medicine and hygiene.

[20]  P. Garg,et al.  Economic burden of dengue infections in India. , 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[21]  Duane J. Gubler,et al.  Dengue and Dengue Hemorrhagic Fever , 1998, Clinical Microbiology Reviews.

[22]  J. Castro,et al.  The health and economic impact of dengue in Latin America. , 2007, Cadernos de saude publica.

[23]  James E. Robinson,et al.  Neutralizing and non-neutralizing monoclonal antibodies against dengue virus E protein derived from a naturally infected patient , 2010, Virology Journal.

[24]  Vicente Bayard,et al.  Clinical characteristics and national economic cost of the 2005 dengue epidemic in Panama. , 2008, The American journal of tropical medicine and hygiene.

[25]  G. Crane Dengue haemorrhagic fever: diagnosis, treatment, prevention and control , 1999 .

[26]  C. Dolea,et al.  World Health Organization , 1949, International Organization.

[27]  S. Rosenbaum,et al.  Examining the Experiences of Puerto Rico's Community Health Centers Under the Government Health Insurance Plan , 2009 .

[28]  J. Torres,et al.  The health and economic impact of dengue in , 2007 .

[29]  A. Nisalak,et al.  Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study , 2007, The Lancet.

[30]  S. Halstead,et al.  Cost of dengue cases in eight countries in the Americas and Asia: a prospective study. , 2009, The American journal of tropical medicine and hygiene.

[31]  T. Pokka,et al.  Costs arising from otitis media , 1999, Acta paediatrica.

[32]  H. Margolis,et al.  Health Economics of Dengue: A Systematic Literature Review and Expert Panel's Assessment , 2011, The American journal of tropical medicine and hygiene.

[33]  D. Morens,et al.  Epidemic dengue fever in Puerto Rico, 1977: a cost analysis. , 1979, The American journal of tropical medicine and hygiene.

[34]  J. Rigau-Pérez,et al.  Hospitalizations for suspected dengue in Puerto Rico, 1991-1995: estimation by capture-recapture methods. The Puerto Rico Association of Epidemiologists. , 1999, The American journal of tropical medicine and hygiene.

[35]  Chandralekha,et al.  The north Indian dengue outbreak 2006: a retrospective analysis of intensive care unit admissions in a tertiary care hospital. , 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[36]  Weltgesundheitsorganisation Weekly epidemiological monitor , 2012 .

[37]  D. Webster,et al.  Progress towards a dengue vaccine. , 2009, The Lancet. Infectious diseases.

[38]  A. Nisalak,et al.  Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. , 2005, The American journal of tropical medicine and hygiene.

[39]  S. Halstead,et al.  Dengue , 1872, The Lancet.

[40]  M. Keech,et al.  The Impact of Influenza on Working Days Lost , 2008, PharmacoEconomics.

[41]  D. Canyon Historical analysis of the economic cost of dengue in Australia. , 2008, Journal of vector borne diseases.

[42]  J. Rigau-Pérez,et al.  Cómo responder a una epidemia de dengue: visión global y experiencia en Puerto Rico , 2005 .

[43]  S. Halstead,et al.  Pathogenesis of dengue: challenges to molecular biology. , 1988, Science.

[44]  D. Greenberg,et al.  The burden of acute otitis media on the patient and the family , 2003, European Journal of Pediatrics.

[45]  D. Shepard,et al.  Cost of dengue in Thailand , 2010 .

[46]  D. Mavalankar,et al.  Quantifying the Impact of Chikungunya and Dengue on Tourism Revenues , 2009 .

[47]  D. Gubler,et al.  Dengue and dengue hemorrhagic fever in Latin America and the Caribbean. , 2000, Infectious disease clinics of North America.

[48]  Debarati Guha-Sapir,et al.  Emerging Themes in Epidemiology BioMed Central Review , 2005 .

[49]  D. Gubler,et al.  Update on Dengue: Epidemiology, Virus Evolution, Antiviral Drugs, and Vaccine Development , 2010, Current infectious disease reports.

[50]  U. Thisyakorn,et al.  Dengue infection: a growing global health threat. , 2007, Bioscience trends.

[51]  Rosanna W. Peeling,et al.  Dengue: a continuing global threat , 2010, Nature Reviews Microbiology.

[52]  A. Nisalak,et al.  Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. , 1989, The American journal of tropical medicine and hygiene.

[53]  Lin Yuan,et al.  What is the solution? , 1984, Nature.

[54]  D. Gubler,et al.  Using disability-adjusted life years to assess the economic impact of dengue in Puerto Rico: 1984-1994. , 1998, The American journal of tropical medicine and hygiene.

[55]  O. Horstick,et al.  Editorial: Towards a global dengue research agenda , 2007, Tropical medicine & international health : TM & IH.

[56]  H. Margolis,et al.  Cost of dengue and other febrile illnesses to households in rural Cambodia: a prospective community-based case-control study , 2009, BMC public health.

[57]  G. Clark,et al.  [How to respond to a dengue epidemic: overview and experience in Puerto Rico]. , 2005, Revista panamericana de salud publica = Pan American journal of public health.