Gut microbiota and circadian rhythm in Alzheimer’s disease pathophysiology: a review and hypothesis on their association

[1]  X. Liao,et al.  Reducing light exposure enhances the circadian rhythm of the biological clock through interactions with the gut microbiota. , 2022, The Science of the total environment.

[2]  Jianfeng Luo,et al.  Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study , 2022, Nutrients.

[3]  S. Askarova,et al.  Study of gut microbiota alterations in Alzheimer's dementia patients from Kazakhstan , 2022, Scientific Reports.

[4]  Xuefeng Yu,et al.  Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions , 2022, Aging cell.

[5]  O. Hansson,et al.  Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers , 2022, Alzheimer's research & therapy.

[6]  E. Musiek,et al.  Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden , 2022, Scientific Reports.

[7]  Keyvan Yousefi,et al.  The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer’s Disease: An Overview and Update on New Developments , 2022, Cellular and Molecular Neurobiology.

[8]  Yan Yang,et al.  A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease , 2022, International journal of molecular sciences.

[9]  D. Bechtold,et al.  Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism , 2021, bioRxiv.

[10]  Kangding Liu,et al.  Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target , 2021, Mechanisms of Ageing and Development.

[11]  Jong-Seok Moon,et al.  Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer’s Disease , 2020, International journal of molecular sciences.

[12]  S. Leutgeb,et al.  Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes , 2020, Neuron.

[13]  D. P. Singh,et al.  Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6 , 2020, Cells.

[14]  M. Deli,et al.  Sleep loss disrupts pericyte-brain endothelial cell interactions impairing blood-brain barrier function , 2020, Brain, Behavior, and Immunity.

[15]  A. Xie,et al.  BMAL1 regulation of microglia‐mediated neuroinflammation in MPTP‐induced Parkinson's disease mouse model , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  Q. Tang,et al.  BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress , 2020, Circulation research.

[17]  A. Hannan,et al.  Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease , 2020, Neurobiology of Disease.

[18]  E. Musiek,et al.  Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease , 2019, Aging cell.

[19]  J. Lübke,et al.  Bmal1‐deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes , 2019, Glia.

[20]  Mitchell H. Murdock,et al.  The microbiota regulate neuronal function and fear extinction learning , 2019, Nature.

[21]  Zhengquan Yu,et al.  Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice , 2019, Journal of pineal research.

[22]  N. Bray The microbiota–gut–brain axis , 2019 .

[23]  Mingmei Zhou,et al.  Chronic paradoxical sleep deprivation‐induced depression‐like behavior, energy metabolism and microbial changes in rats , 2019, Life sciences.

[24]  Vanni Bucci,et al.  Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway , 2019, mBio.

[25]  P. Sassone-Corsi,et al.  BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis , 2019, Cell.

[26]  S. Gerber,et al.  Common miRNA Patterns of Alzheimer’s Disease and Parkinson’s Disease and Their Putative Impact on Commensal Gut Microbiota , 2019, Front. Neurosci..

[27]  C. Consolandi,et al.  Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism , 2018, Movement disorders : official journal of the Movement Disorder Society.

[28]  H. Reinke,et al.  Crosstalk between metabolism and circadian clocks , 2019, Nature Reviews Molecular Cell Biology.

[29]  W. Lukiw,et al.  Lipopolysaccharide-stimulated, NF-kB-, miRNA-146a- and miRNA-155-mediated molecular-genetic communication between the human gastrointestinal tract microbiome and the brain. , 2019, Folia neuropathologica.

[30]  A. Nouvenne,et al.  Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging. , 2019, Advances in experimental medicine and biology.

[31]  Liang Shen,et al.  Associations Between Gut Microbiota and Alzheimer's Disease: Current Evidences and Future Therapeutic and Diagnostic Perspectives. , 2019, Journal of Alzheimer's disease : JAD.

[32]  F. Scheer,et al.  Circadian clocks and insulin resistance , 2018, Nature Reviews Endocrinology.

[33]  J. Takahashi,et al.  Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1 , 2018, bioRxiv.

[34]  K. Foster,et al.  Why does the microbiome affect behaviour? , 2018, Nature Reviews Microbiology.

[35]  Hua Zhu,et al.  The intestinal microbiome and Alzheimer's disease: A review , 2018, Animal models and experimental medicine.

[36]  Trevor O. Kirby,et al.  The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue , 2018, Medical sciences.

[37]  B. Vincent Protective roles of melatonin against the amyloid‐dependent development of Alzheimer's disease: A critical review , 2018, Pharmacological research.

[38]  Y. Takaesu Circadian rhythm in bipolar disorder: A review of the literature , 2018, Psychiatry and clinical neurosciences.

[39]  E. Brzozowska,et al.  The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review , 2018, Molecular Neurobiology.

[40]  H. Braakman,et al.  Can epilepsy be treated by antibiotics? , 2018, Journal of Neurology.

[41]  O. Froy,et al.  The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects. , 2018, Endocrine reviews.

[42]  J. Attems,et al.  SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease , 2018, Scientific Reports.

[43]  B. Dell’Osso,et al.  Dietary Neurotransmitters: A Narrative Review on Current Knowledge , 2018, Nutrients.

[44]  Fen Wang,et al.  Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson's Disease , 2018, Oxidative medicine and cellular longevity.

[45]  D. Holtzman,et al.  Regulation of amyloid-β dynamics and pathology by the circadian clock , 2018, The Journal of experimental medicine.

[46]  W. Lukiw,et al.  Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease , 2018, Front. Neurol..

[47]  Bruno Bonaz,et al.  The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis , 2018, Front. Neurosci..

[48]  W. Banks,et al.  Gut reactions: How the blood–brain barrier connects the microbiome and the brain , 2017, Experimental biology and medicine.

[49]  E. Quigley Microbiota-Brain-Gut Axis and Neurodegenerative Diseases , 2017, Current Neurology and Neuroscience Reports.

[50]  W. Lukiw,et al.  Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain , 2017, Front. Immunol..

[51]  W. Lukiw,et al.  Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus , 2017, Front. Cell. Infect. Microbiol..

[52]  H. Abdolmaleky,et al.  Microbiome, inflammation, epigenetic alterations, and mental diseases , 2017, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[53]  T. Dinan,et al.  The Microbiome-Gut-Brain Axis in Health and Disease. , 2017, Gastroenterology Clinics of North America.

[54]  L. Berdondini,et al.  Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling , 2017, Nature Communications.

[55]  G. Frisoni,et al.  Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota , 2017, Scientific Reports.

[56]  G. Frisoni,et al.  Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly , 2017, Neurobiology of Aging.

[57]  Bin Zhao,et al.  The Gut Microbiota and Alzheimer's Disease. , 2017, Journal of Alzheimer's disease : JAD.

[58]  T. Dinan,et al.  Anxiety, Depression, and the Microbiome: A Role for Gut Peptides , 2017, Neurotherapeutics.

[59]  F. D’Antonio,et al.  Sundowning in Dementia: Clinical Relevance, Pathophysiological Determinants, and Therapeutic Approaches , 2016, Front. Med..

[60]  H. Wekerle The gut-brain connection: triggering of brain autoimmune disease by commensal gut bacteria. , 2016, Rheumatology.

[61]  C. DeCarli,et al.  Gram-negative bacterial molecules associate with Alzheimer disease pathology , 2016, Neurology.

[62]  D. Holtzman,et al.  Mechanisms linking circadian clocks, sleep, and neurodegeneration , 2016, Science.

[63]  Yu-ping Wang,et al.  Gut Microbiota-brain Axis , 2016, Chinese medical journal.

[64]  Paul Edison,et al.  Neuroinflammation in Alzheimer's disease: Current evidence and future directions , 2016, Alzheimer's & Dementia.

[65]  Joanna Mattis,et al.  Circadian Rhythms, Sleep, and Disorders of Aging , 2016, Trends in Endocrinology & Metabolism.

[66]  X. Zhang,et al.  Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population. , 2015, Genetics and molecular research : GMR.

[67]  Frederic D Bushman,et al.  Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock , 2015, Proceedings of the National Academy of Sciences.

[68]  Alan L. Hutchison,et al.  Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. , 2015, Cell host & microbe.

[69]  M. Carabotti,et al.  The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems , 2015, Annals of gastroenterology.

[70]  Hyundong Song,et al.  Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease , 2015, Molecular Neurodegeneration.

[71]  E. Pekkonen,et al.  Gut microbiota are related to Parkinson's disease and clinical phenotype , 2015, Movement disorders : official journal of the Movement Disorder Society.

[72]  D. Fuchs,et al.  Elevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut , 2015, Journal of Neural Transmission.

[73]  L. Galland The gut microbiome and the brain. , 2014, Journal of medicinal food.

[74]  Eran Segal,et al.  Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis , 2014, Cell.

[75]  L. Gioglio,et al.  Can a bacterial endotoxin be a key factor in the kinetics of amyloid fibril formation? , 2014, Journal of Alzheimer's disease : JAD.

[76]  D. Holtzman,et al.  Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. , 2013, The Journal of clinical investigation.

[77]  Lucie Geurts,et al.  Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity , 2013, Proceedings of the National Academy of Sciences.

[78]  Jacob Richards,et al.  Mechanism of the circadian clock in physiology. , 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

[79]  C. Johnson,et al.  Circadian Disruption Leads to Insulin Resistance and Obesity , 2013, Current Biology.

[80]  M. Surette,et al.  The interplay between the intestinal microbiota and the brain , 2012, Nature Reviews Microbiology.

[81]  Kristopher L. Nazor,et al.  Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells , 2012, Nature.

[82]  W. Oertel,et al.  Intravenous Immunoglobulins as a Treatment for Alzheimer’s Disease , 2010, Drugs.

[83]  Diane B. Boivin,et al.  Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects , 2011, Journal of biological rhythms.

[84]  S. Bloom,et al.  Hormonal interactions between gut and brain. , 2010, Discovery medicine.

[85]  G. MacQueen,et al.  Bacterial infection causes stress-induced memory dysfunction in mice , 2010, Gut.

[86]  Joseph S. Takahashi,et al.  Disruption of the Clock Components CLOCK and BMAL 1 Leads to Hypoinsulinemia and Diabetes , 2012 .

[87]  E. Borrelli,et al.  Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation , 2010, PloS one.

[88]  E. Masliah,et al.  APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis , 2009, Brain Structure and Function.

[89]  D. Holtzman,et al.  The Role of Apolipoprotein E in Alzheimer's Disease , 2009, Neuron.

[90]  Florian Kreppel,et al.  SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation , 2008, Cell.

[91]  H. Yamamori,et al.  Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus , 2008, Journal of neuropathology and experimental neurology.

[92]  J. Ferrières,et al.  Metabolic Endotoxemia Initiates Obesity and Insulin Resistance , 2007, Diabetes.

[93]  J. Wesson Ashford,et al.  APOE genotype effects on alzheimer’s disease onset and epidemiology , 2007, Journal of Molecular Neuroscience.

[94]  P. Lucassen,et al.  Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus , 2006, Neurobiology of Disease.

[95]  Peter Davies,et al.  Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides* , 2005, Journal of Biological Chemistry.

[96]  E. Masliah,et al.  Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. , 2005, The American journal of pathology.

[97]  Fred W. Turek,et al.  Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice , 2005, Science.

[98]  B. Price,et al.  Memory dysfunction. , 2005, The New England journal of medicine.

[99]  A. R.,et al.  Review of literature , 1969, American Potato Journal.

[100]  J. Csernansky,et al.  Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress , 2004, Neuroscience.

[101]  P. Scheltens,et al.  Genes for peripheral neuropathy and their relevance to clinical practice , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[102]  P. Hof,et al.  The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice , 2004, Experimental Neurology.

[103]  D. Selkoe,et al.  Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. , 2004, Protein and peptide letters.

[104]  T. Albright,et al.  Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease , 2004, Acta Neuropathologica.

[105]  D. Borchelt,et al.  Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice , 2003, Neurobiology of Disease.

[106]  B. Bahr,et al.  Lysosomal Activation Is a Compensatory Response Against Protein Accumulation and Associated Synaptopathogenesis—An Approach for Slowing Alzheimer Disease? , 2003, Journal of neuropathology and experimental neurology.

[107]  John T. Finn,et al.  Axonal Self-Destruction and Neurodegeneration , 2002, Science.

[108]  Toshiyuki Okano,et al.  Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1* , 2002, The Journal of Biological Chemistry.

[109]  T. Saido,et al.  Metabolic Regulation of Brain Aβ by Neprilysin , 2001, Science.

[110]  C. Finch,et al.  Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? , 2001, Trends in Neurosciences.

[111]  S. Scheff,et al.  Alzheimer's disease-related synapse loss in the cingulate cortex. , 2001, Journal of Alzheimer's disease : JAD.

[112]  E. Masliah Recent advances in the understanding of the role of synaptic proteins in Alzheimer's Disease and other neurodegenerative disorders. , 2001, Journal of Alzheimer's disease : JAD.

[113]  John B. Hogenesch,et al.  Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals , 2000, Cell.

[114]  J. Trojanowski,et al.  “Fatal Attractions” of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders , 2000, Annals of the New York Academy of Sciences.

[115]  Y. Pang,et al.  Cytokine Induction in Fetal Rat Brains and Brain Injury in Neonatal Rats after Maternal Lipopolysaccharide Administration , 2000, Pediatric Research.

[116]  D. Selkoe,et al.  Translating cell biology into therapeutic advances in Alzheimer's disease , 1999, Nature.

[117]  S. DeKosky,et al.  Structural correlates of cognition in dementia: quantification and assessment of synapse change. , 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[118]  D. Price,et al.  Role of the β‐amyloid protein in Alzheimer's disease , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[119]  D. Salmon,et al.  Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.

[120]  D. Selkoe Amyloid β protein precursor and the pathogenesis of Alzheimer's disease , 1989, Cell.

[121]  T. Beach,et al.  Patterns of gliosis in alzheimer's disease and aging cerebrum , 1989, Glia.

[122]  S. Styren,et al.  Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease , 1988, Neurobiology of Aging.

[123]  Z. Khachaturian Diagnosis of Alzheimer's disease. , 1985, Archives of neurology.

[124]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[125]  R. DeTeresa,et al.  Some morphometric aspects of the brain in senile dementia of the alzheimer type , 1981, Annals of neurology.

[126]  C. Aring,et al.  A CRITICAL REVIEW , 1939, Journal of neurology and psychiatry.