RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

[1]  H. Erdjument-Bromage,et al.  Microbore reversed-phase high-performance liquid chromatographic purification of peptides for combined chemical sequencing-laser-desorption mass spectrometric analysis. , 1994, Journal of chromatography. A.

[2]  D. Fruman,et al.  Immunophilins in protein folding and immunosuppression 1 , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  J. Kunz,et al.  TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. , 1994, Molecular biology of the cell.

[4]  P. Tempst,et al.  Combined Edman-Chemical and Laser-Desorption Mass Spectrometric Approaches to Micro Peptide Sequencing: Optimization and Applications , 1994 .

[5]  K. Catt,et al.  Inositol polyphosphates are not increased by overexpression of Ins(1,4,5)P3 3-kinase but show cell-cycle dependent changes in growth factor-stimulated fibroblasts. , 1994, Molecular biology of the cell.

[6]  A. Marks,et al.  Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line. , 1993, The Journal of biological chemistry.

[7]  A. Marks,et al.  The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. , 1993, The Journal of biological chemistry.

[8]  R. Abraham,et al.  Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. , 1993, The Journal of biological chemistry.

[9]  S. Schreiber,et al.  FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. , 1993, The Journal of biological chemistry.

[10]  M. Mclaughlin,et al.  Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity , 1993, Molecular and cellular biology.

[11]  J. Kunz,et al.  Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. , 1993, Trends in biochemical sciences.

[12]  J. Kunz,et al.  Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.

[13]  J. Liu.  FK506 and ciclosporin: molecular probes for studying intracellular signal transduction. , 1993, Trends in pharmacological sciences.

[14]  H. Erdjument-Bromage,et al.  Successful Peptide Sequencing With Femtomole Level PTH-Analysis: A Commentary , 1993 .

[15]  Y. Jan,et al.  Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. , 1992, Science.

[16]  Solomon H. Snyder,et al.  High brain densities of the immunophilin FKBP colocalized with calcineurin , 1992, Nature.

[17]  G. Crabtree,et al.  Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase , 1992, Nature.

[18]  G. Crabtree,et al.  Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.

[19]  B. Bierer,et al.  Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. , 1992, The Journal of biological chemistry.

[20]  W. Rutter,et al.  Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. , 1992, Science.

[21]  H. Erdjument-Bromage,et al.  FK506 binding protein associated with the calcium release channel (ryanodine receptor). , 1992, The Journal of biological chemistry.

[22]  J. Heitman,et al.  Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression. , 1992, The New biologist.

[23]  C. Heiner,et al.  Rapid and reliable fluorescent cycle sequencing of double-stranded templates. , 1992, DNA sequence : the journal of DNA sequencing and mapping.

[24]  G. Crabtree,et al.  Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A , 1991, Nature.

[25]  Stuart L. Schreiber,et al.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes , 1991, Cell.

[26]  J. Heitman,et al.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast , 1991, Science.

[27]  R. Bradshaw,et al.  Differential induction of primary-response (TIS) genes in PC12 pheochromocytoma cells and the unresponsive variant PC12nnr5. , 1991, The Journal of biological chemistry.

[28]  L. Cantley,et al.  Oncogenes and signal transduction , 1991, Cell.

[29]  S. Schreiber,et al.  Chemistry and biology of the immunophilins and their immunosuppressive ligands. , 1991, Science.

[30]  L A Herzenberg,et al.  Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[31]  L. Cantley,et al.  Purification and characterization of phosphoinositide 3-kinase from rat liver. , 1990, The Journal of biological chemistry.

[32]  S. Burakoff,et al.  Probing immunosuppressant action with a nonnatural immunophilin ligand , 1990, Science.

[33]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[34]  Andrzej Galat,et al.  Molecular cloning and overexpression of the human FK506-binding protein FKBP , 1990, Nature.

[35]  N. Sigal,et al.  The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells. , 1990, Journal of immunology.

[36]  N. Sigal,et al.  Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. , 1990, Journal of immunology.

[37]  P. Tempst,et al.  Internal sequence analysis of proteins separated on polyacrylamide gels at the submicrogram level: Improved methods, applications and gene cloning strategies , 1990, Electrophoresis.

[38]  W. Neupert,et al.  Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae , 1989, Nature.

[39]  P. Tempst,et al.  Examination of automated polypeptide sequencing using standard phenyl isothiocyanate reagent and subpicomole high-performance liquid chromatographic analysis. , 1989, Analytical biochemistry.

[40]  S. Schreiber,et al.  A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase , 1989, Nature.

[41]  Nolan H. Sigal,et al.  A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin , 1989, Nature.

[42]  P. Libby,et al.  PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells , 1989, Cell.

[43]  S. Subramani,et al.  Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Smith,et al.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. , 1988, Gene.

[45]  L. Cantley,et al.  Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate , 1988, Nature.

[46]  M. Kozak.  An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. , 1987, Nucleic acids research.

[47]  M. Okuhara,et al.  FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. , 1987, The Journal of antibiotics.

[48]  Lloyd M. Smith,et al.  Fluorescence detection in automated DNA sequence analysis , 1986, Nature.

[49]  Borel Jf.  Ciclosporin and its future. , 1986 .

[50]  D. Speicher,et al.  Cyclophilin: a specific cytosolic binding protein for cyclosporin A. , 1984, Science.

[51]  T. Waldmann,et al.  Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Martel,et al.  Inhibition of the immune response by rapamycin, a new antifungal antibiotic. , 1977, Canadian journal of physiology and pharmacology.

[53]  R. Hutchison.  The formation of the Earth , 1974, Nature.

[54]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[55]  J. Holland,et al.  Size Distribution of Polypeptide Chains in Cells , 1970, Nature.