2,3-Dibromo-3-(4-chlorophenyl)-1-(2-hydroxyphenyl)propan-1-one

In the title molecule, C15H11Br2ClO2, an S(6) ring motif is formed via an intramolecular O—H⋯O hydrogen bond. The dihedral angle formed between the chloro- and hydroxy-substituted benzene rings is 34.10 (15)°. In the crystal, weak intermolecular C—H⋯O hydrogen bonds link the molecules into chains along the c axis.

[1]  2,3-Dibromo-3-(4-methoxyphenyl)-1-phenylpropan-1-one , 2006 .

[2]  A. M. Vijesh,et al.  2,3‐Dibromo‐1‐(3‐bromo‐2‐thienyl)‐3‐(4‐fluorophenyl)propan‐1‐one , 2007 .

[3]  M. Nakayama,et al.  Second harmonic generation and crystal growth of substituted thienyl chalcone , 1991 .

[4]  M. Payá,et al.  The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production. , 2002, Bioorganic & medicinal chemistry letters.

[5]  Anthony L. Spek,et al.  Structure validation in chemical crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[6]  Masamichi Aoki,et al.  Novel Organic SHG Materials , 1998 .

[7]  H. Yathirajan,et al.  Do C-H...O and C-H...pi interactions help to stabilize a non-centrosymmetric structure for racemic 2,3-dibromo-1,3-diphenylpropan-1-one? , 2005, Acta crystallographica. Section C, Crystal structure communications.

[8]  A. Dinkova-Kostova,et al.  Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. , 1998, Journal of medicinal chemistry.

[9]  G. Sheldrick A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[10]  Raymond E. Davis,et al.  Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in Crystals , 1995 .

[11]  H. S. Yathirajan,et al.  3-(Biphenyl-4-yl)-2,3-dibromo-1-(2,4-dichloro­phen­yl)propan-1-one , 2007 .

[12]  T. Liljefors,et al.  Antileishmanial chalcones: statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis. , 1998, Journal of medicinal chemistry.

[13]  Mei Liu,et al.  Structure-activity relationships of antileishmanial and antimalarial chalcones. , 2003, Bioorganic & medicinal chemistry.

[14]  Badiadka Narayana,et al.  2,3-Dibromo-1-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]propan-1-one , 2006 .

[15]  B. V. Ashalatha,et al.  Synthesis, crystal growth and studies on non-linear optical property of new chalcones , 2006 .

[16]  B. Guérin,et al.  3-Methyl-4-methoxy-4′-nitrostilbene (MMONS): Crystal structure of a highly efficient material for second-harmonic generation , 1989 .

[17]  B. Sarojini,et al.  Growth, characterization and nonlinear optical property of chalcone derivative , 2002 .