Non-syndromic cleft lip with or without palate susceptible SNPs are associated with hyperdontia.

BACKGROUND Non-syndromic supernumerary teeth (NSST) or hyperdontia may share common genetic determinants with non-syndromic cleft lip with or without palate (NSCL/P). The aim of this study was to test the associations between five genome-wide associated NSCL/P susceptible single nucleotide polymorphisms (SNPs) (rs2235371, rs7078160, rs8049367, rs4791774 and rs13041247) and the occurrence of NSST. MATERIALS AND METHODS 163 cases and 326 controls were recruited and their genomic DNA were extracted from blood samples. Five NSCL/P susceptible SNPs (rs2235371, rs7078160, rs8049367, rs4791774 and rs13041247) were genotyped by TaqMan method. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the associations between the SNPs and the risk of NSST by PLINK software. RESULTS Rs4791774 (A>G) and rs13041247 (T>C) were associated with risk of NSST (rs4791774: Padd =0.011, OR, 95% CI=0.62, 0.43-0.90; rs13041247: Phomo =0.031, OR, 95% CI=1.79, 1.05-3.05) and one supernumerary tooth (rs4791774: Pdom =0.009, OR, 95% CI=0.56, 0.36-0.87; rs13041247: Phomo =0.034, OR, 95% CI=1.82, 1.05-3.15). Rs4791774 (A>G) was also showed association with risk of upper arch supernumerary teeth only (Padd =0.010, OR, 95% CI=0.60, 0.41-0.89). CONCLUSION NSCL/P susceptible loci rs4791774 (A>G) and rs13041247 (T>C) were associated with the risk of supernumerary teeth. This article is protected by copyright. All rights reserved.

[1]  J. Schleutker,et al.  Risk Prediction of Prostate Cancer with Single Nucleotide Polymorphisms and Prostate Specific Antigen , 2019, The Journal of urology.

[2]  D. Bussaneli,et al.  Rethinking isolated cleft lip and palate as a syndrome. , 2018, Oral surgery, oral medicine, oral pathology and oral radiology.

[3]  H. Pakshir,et al.  Prevalence and Characteristics of Developmental Dental Anomalies in Iranian Orofacial Cleft Patients , 2017, Journal of dentistry.

[4]  Tao Song,et al.  Association between PAX7 and NTN1 gene polymorphisms and nonsyndromic orofacial clefts in a northern Chinese population , 2017, Medicine.

[5]  A. Cvekl,et al.  Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation. , 2016, The Einstein journal of biology and medicine : EJBM.

[6]  E. Madrigal-Santillán,et al.  What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration? , 2015, Cells.

[7]  Hongbing Shen,et al.  Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate , 2022 .

[8]  M. Dundar,et al.  Genetic background of supernumerary teeth , 2015, European journal of dentistry.

[9]  Zhengjun Peng,et al.  Expression of Oct-4, SOX-2, and MYC in dental papilla cells and dental follicle cells during in-vivo tooth development and in-vitro co-culture. , 2014, European journal of oral sciences.

[10]  N. King,et al.  Aetiology of supernumerary teeth: a literature review , 2013, European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry.

[11]  B. S. Kumar,et al.  Prevalence rate of supernumerary teeth among non-syndromic South Indian population: An analysis , 2012, Journal of pharmacy & bioallied sciences.

[12]  M. Brown,et al.  Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. , 2012, American journal of human genetics.

[13]  Meilin Wang,et al.  Different roles of two novel susceptibility loci for nonsyndromic orofacial clefts in a Chinese Han population. , 2011, American journal of medical genetics. Part A.

[14]  B. Basseri,et al.  Current National Incidence, Trends, and Health Care Resource Utilization of Cleft Lip–Cleft Palate , 2011, Plastic and reconstructive surgery.

[15]  T. Beaty,et al.  Cleft lip and palate: understanding genetic and environmental influences , 2011, Nature Reviews Genetics.

[16]  M. Mahdian,et al.  Supernumerary teeth amongst Iranian orthodontic patients. A retrospective radiographic and clinical survey , 2011, Acta odontologica Scandinavica.

[17]  Katsuhisa Horimoto,et al.  Induction of Pluripotent Stem Cells from Human Third Molar Mesenchymal Stromal Cells*♦ , 2010, The Journal of Biological Chemistry.

[18]  Holger Schwender,et al.  A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 , 2010, Nature Genetics.

[19]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[20]  Jing Chen,et al.  ToppGene Suite for gene list enrichment analysis and candidate gene prioritization , 2009, Nucleic Acids Res..

[21]  G. Fraser,et al.  An Ancient Gene Network Is Co-opted for Teeth on Old and New Jaws , 2009, PLoS biology.

[22]  G. Fraser,et al.  A periodic pattern generator for dental diversity , 2008, BMC Biology.

[23]  Soo Young Lee,et al.  MafB negatively regulates RANKL-mediated osteoclast differentiation. , 2007, Blood.

[24]  H. Lesot,et al.  Origin of the Deciduous Upper Lateral Incisor and its Clinical Aspects , 2006, Journal of dental research.

[25]  M. Salminen,et al.  Developmentally regulated expression of Netrin‐1 and ‐3 in the embryonic mouse molar tooth germ , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

[26]  D. Botstein,et al.  Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease , 2003, Nature Genetics.

[27]  L. Rajab,et al.  Supernumerary teeth: review of the literature and a survey of 152 cases. , 2002, International journal of paediatric dentistry.

[28]  M. Garvey,et al.  Supernumerary teeth--an overview of classification, diagnosis and management. , 1999, Journal.

[29]  J. Schleutker,et al.  Risk Prediction of Prostate Cancer with Single Nucleotide Polymorphisms and Prostate Specific Antigen. , 2019, The Journal of urology.