Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

1. DRUG DISCOVERY- 1990.- 2. DATA DISPLAY AND ANALYSIS STRATEGIES FOR THE NCI DISEASE-ORIENTED IN VITRO ANTITUMOR DRUG SCREEN.- 3. DISCOVERY OF SOLID TUMOR ACTIVE AGENTS USING A SOFT-AGAR-COLONY-FORMATION DISK-DIFFUSION- ASSAY.- 4. THYMIDYLATE SYNTHASE INHIBITION OF MODIFIED QUINAZOLINE ANTIFOLATES.- 5. DNA-MINOR GROOVE BINDING ANTICANCER AGENTS.- 6. 2-((ARYLMETHYL)AMIN0)-l,3-PR0PANEDI0LS (AMAPS) DISCOVERY, SELECTION AND DEVELOPMENT OF FOUR CLINICAL CANDIDATES.- 7. MECHANISM-BASED APPROACHES TO CANCER DRUG DISCOVERY.- 8. DISCOVERY AND BULK PRODUCTION OF NATURAL PRODUCTS WITH ANTICANCER ACTIVITY: THE ROLE OF CHEMICAL ECOLOGY.- 9. CHEMICAL APPROACHES TO IMPROVED RADIOTHERAPY.- 10. LARGE SCALE ANTICANCER DRUG SCREENING AT STERLING DRUG INC..- 11. ARE ANTISENSE OLIG0NUCLEOTIDES THERAPEUTIC AGENTS OF THE FUTURE?.- 12. SUPERCOMPUTER AIDED DRUG DESIGN: APPLICATION IN ONCOLOGY AND AIDS.- 13. EXTRACHROMOSOMAL DNA AS A TARGET FOR DRUG DEVELOPMENT.- 14. PROSPECTIVE EVALUATION OF A PREDICTIVE MODEL FOR PLASMA CONCENTRATION-VERSUS-TIME PROFILES OF INVESTIGATIONAL ANTICANCER DRUGS IN PATIENTS.- 15. AGENT-DIRECTED PRECLINICAL TOXICOLOGY FOR NEW ANTINFOPLASTIC DRUGS.- 16. PRECLINICAL STUDIES WITH BREQUINAR SODIUM: A NOVEL ANTICANCER AGENT.- 17. DIPHTHERIA TOXIN-RELATED PEPTIDE HORMONE FUSION PROTEINS: NEW TOXINS WITH THERAPEUTIC POTENTIAL.- 18. ANTI-GROWTH FACTOR RECEPTOR ANTIBODIES AS THERAPY FOR CANCER.- 19. REGULATION OF POLYAMINE BIOSYNTHETIC ACTIVITY AND HOMEOSTASIS AS A NOVEL ANTIPROLIFERATIVE STRATEGY.- 20. ESPERAMICIN A1 (BMY28175)- A NOVEL ANTI- TUMOR AGENT OF THE DIYNE-ENE CLASS.- 21. MODIFIED 2-TUMOR (L1210, COLON 38) ASSAY TO SCREEN FOR SOLID TUMOR SELECTIVE AGENTS.- 22. 5-FLUOROURACIL: SCHEDULE OPTIMIZATION IN METASTATIC COLORECTAL CANCER.- 23. PRECLINICAL ANTITUMOR EFFICACY OF TAXOTERE (RP56976, NSC 628503), A TAXOL ANALOG AND OF RP60475 (NSC645008), A NEW BENZOPYRI- DOINDOLE.

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