The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.

[1]  B. Thompson,et al.  Pygopus Residues Required for its Binding to Legless Are Critical for Transcription and Development* , 2004, Journal of Biological Chemistry.

[2]  F. Melchior,et al.  Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. , 2003, Molecular cell.

[3]  J. Lukas,et al.  HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. , 2003, Nucleic acids research.

[4]  M. Kagey,et al.  The Polycomb Protein Pc2 Is a SUMO E3 , 2003, Cell.

[5]  Mariann Bienz,et al.  Nuclear export of the APC tumour suppressor controls β‐catenin function in transcription , 2003, The EMBO journal.

[6]  Hans Clevers,et al.  The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells , 2002, Cell.

[7]  Philippe Soriano,et al.  Overlapping and Unique Roles for C-Terminal Binding Protein 1 (CtBP1) and CtBP2 during Mouse Development , 2002, Molecular and Cellular Biology.

[8]  A. Kelley,et al.  The transcriptional repressor Brinker antagonizes Wingless signaling. , 2002, Genes & development.

[9]  J. Rüschoff,et al.  T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis. , 2002, Cancer research.

[10]  Mariann Bienz,et al.  The subcellular destinations of apc proteins , 2002, Nature Reviews Molecular Cell Biology.

[11]  Mariann Bienz,et al.  A Drosophila APC tumour suppressor homologue functions in cellular adhesion , 2002, Nature Cell Biology.

[12]  G. Chinnadurai,et al.  CtBP, an unconventional transcriptional corepressor in development and oncogenesis. , 2002, Molecular cell.

[13]  W. Weis,et al.  Molecular mechanisms of β‐catenin recognition by adenomatous polyposis coli revealed by the structure of an APC–β‐catenin complex , 2001, The EMBO journal.

[14]  M. Bienz,et al.  Actin‐dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells , 2001, The EMBO journal.

[15]  H Clevers,et al.  The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation , 2001, The EMBO journal.

[16]  M. Bienz,et al.  EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye , 2001, EMBO reports.

[17]  Raymond L. White,et al.  APC‐mediated downregulation of β‐catenin activity involves nuclear sequestration and nuclear export , 2000, EMBO reports.

[18]  Walter Birchmeier,et al.  Hot spots in β-catenin for interactions with LEF-1, conductin and APC , 2000, Nature Structural Biology.

[19]  B. Henderson.  Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover , 2000, Nature Cell Biology.

[20]  Mariann Bienz,et al.  The APC tumour suppressor has a nuclear export function , 2000, Nature.

[21]  P. Polakis.  Wnt signaling and cancer. , 2000, Genes & development.

[22]  M. Waterman,et al.  The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. , 2000, Nucleic acids research.

[23]  J Straub,et al.  APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[24]  D. Baltimore,et al.  Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes. , 2009, Immunity.

[25]  R. Moon,et al.  XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. , 1999, Development.

[26]  M. Bienz,et al.  A new Drosophila APC homologue associated with adhesive zones of epithelial cells , 1999, Nature Cell Biology.

[27]  T. Akiyama,et al.  Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. , 1999, Science.

[28]  M. Levine,et al.  dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo , 1998, The EMBO journal.

[29]  J. Turner,et al.  Cloning and characterization of mCtBP2, a co‐repressor that associates with basic Krüppel‐like factor and other mammalian transcriptional regulators , 1998, The EMBO journal.

[30]  M. Yanagida,et al.  Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. , 1998, Experimental cell research.

[31]  M. Levine,et al.  Interaction of short-range repressors with Drosophila CtBP in the embryo. , 1998, Science.

[32]  S. Parkhurst,et al.  Drosophila CtBP: a Hairy‐interacting protein required for embryonic segmentation and Hairy‐mediated transcriptional repression , 1998, The EMBO journal.

[33]  P. Polakis,et al.  Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. , 1997, Cancer research.

[34]  K. Kinzler,et al.  Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.

[35]  K. Kinzler,et al.  Lessons from Hereditary Colorectal Cancer , 1996, Cell.

[36]  B. Sanson,et al.  Uncoupling cadherin-based adhesion from wingless signalling in Drosophila , 1996, Nature.

[37]  Kerstin Sollerbrant,et al.  The CtBP binding domain in the adenovirus E1A protein controls CR1- dependent transactivation , 1996, Nucleic Acids Res..

[38]  J. M. Boyd,et al.  Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[39]  S. Heinemann,et al.  Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  P. Polakis,et al.  Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. Fukayama,et al.  Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. , 1994, Cancer research.

[42]  J. M. Boyd,et al.  A region in the C‐terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24‐ras mediated transformation, tumorigenesis and metastasis. , 1993, The EMBO journal.

[43]  Yusuke Nakamura,et al.  Mutations of the APC adenomatous polyposis coli) gene , 1993, Human mutation.

[44]  W. Soeller,et al.  In vitro transcription of the Drosophila engrailed gene. , 1988, Genes & development.