Elevated Accumulation of Parabens and their Metabolites in Marine Mammals from the United States Coastal Waters.

The widespread exposure of humans to parabens present in personal care products is well-known. Nevertheless, little is known about the accumulation of parabens in marine organisms. In this study, six parabens and four common metabolites of parabens were measured in 121 tissue samples from eight species of marine mammals collected along the coastal waters of Florida, California, Washington, and Alaska. Methyl paraben (MeP) was the predominant compound found in the majority of the marine mammal tissues analyzed, and the highest concentration found was 865 ng/g (wet weight [wet wt]) in the livers of bottlenose dolphins from Sarasota Bay, FL. 4-Hydroxybenzoic acid (4-HB) was the predominant paraben metabolite found in all tissue samples. The measured concentrations of 4-HB were on the order of hundreds to thousands of ng/g tissue, and these values are some of the highest ever reported in the literature. MeP and 4-HB concentrations showed a significant positive correlation (p < 0.05), which suggested a common source of exposure to these compounds in marine mammals. Trace concentrations of MeP and 4-HB were found in the livers of polar bears from the Chuckchi Sea and Beaufort Sea, which suggested widespread distribution of MeP and 4-HB in the oceanic environment.

[1]  K. Kannan,et al.  Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three East Asian countries. , 2012, Environmental science & technology.

[2]  S. Tanabe,et al.  Trace Element Concentrations in Livers of Polar Bears from Two Populations in Northern and Western Alaska , 2007, Archives of environmental contamination and toxicology.

[3]  J. Larsen,et al.  Lack of oestrogenic effects of food preservatives (parabens) in uterotrophic assays. , 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  K. Kannan,et al.  Urinary levels of endocrine-disrupting chemicals, including bisphenols, bisphenol A diglycidyl ethers, benzophenones, parabens, and triclosan in obese and non-obese Indian children. , 2015, Environmental research.

[5]  C. Mcmillan,et al.  Phenolic acids in seagrasses , 1979 .

[6]  Wei Zhang,et al.  Widespread occurrence and distribution of bisphenol A diglycidyl ether (BADGE) and its derivatives in human urine from the United States and China. , 2012, Environmental science & technology.

[7]  K. Kannan,et al.  Occurrence of and dietary exposure to parabens in foodstuffs from the United States. , 2013, Environmental science & technology.

[8]  H. Harville,et al.  Comparison of paraben stability in human and rat skin. , 2007, Drug metabolism letters.

[9]  G. S. Pope,et al.  Oestrogenic activity of parabens in MCF7 human breast cancer cells , 2002, The Journal of Steroid Biochemistry and Molecular Biology.

[10]  P. Darbre,et al.  Parabens can enable hallmarks and characteristics of cancer in human breast epithelial cells: a review of the literature with reference to new exposure data and regulatory status , 2014, Journal of applied toxicology : JAT.

[11]  N. Skakkebaek,et al.  Systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole-body topical application and reproductive and thyroid hormone levels in humans. , 2007, Environmental science & technology.

[12]  J. Magdalou,et al.  Metabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man. , 2010, Drug metabolism and pharmacokinetics.

[13]  K. Kannan,et al.  Temporal Trends (1992–2007) of Perfluorinated Chemicals in Northern Sea Otters (Enhydra lutris kenyoni) from South-Central Alaska , 2009, Archives of environmental contamination and toxicology.

[14]  F. Williams,et al.  Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture. , 2007, Toxicology and applied pharmacology.

[15]  Alexandros G. Asimakopoulos,et al.  Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue. , 2015, Environment international.

[16]  P. Darbre,et al.  Underarm cosmetics are a cause of breast cancer , 2001, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[17]  E. Lund,et al.  Plasma concentrations of parabens in postmenopausal women and self-reported use of personal care products: the NOWAC postgenome study , 2011, Journal of Exposure Science and Environmental Epidemiology.

[18]  Wei Zhang,et al.  Characteristic profiles of urinary p-hydroxybenzoic acid and its esters (parabens) in children and adults from the United States and China. , 2013, Environmental science & technology.

[19]  A. Calafat,et al.  Urinary Concentrations of Four Parabens in the U.S. Population: NHANES 2005–2006 , 2010, Environmental health perspectives.

[20]  M. Soni,et al.  Safety assessment of esters of p-hydroxybenzoic acid (parabens). , 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[21]  P. Harvey.  Parabens, oestrogenicity, underarm cosmetics and breast cancer: a perspective on a hypothesis , 2003, Journal of applied toxicology : JAT.

[22]  Paul D. Jones,et al.  Organochlorine Pesticides, Polychlorinated Biphenyls, and Butyltin Compounds in Blubber and Livers of Stranded California Sea Lions, Elephant Seals, and Harbor Seals from Coastal California, USA , 2001, Archives of environmental contamination and toxicology.

[23]  S. Oishi.  Effects of butyl paraben on the male reproductive system in mice , 2002, Archives of Toxicology.

[24]  Paul D. Jones,et al.  Accumulation of perfluorooctane sulfonate in marine mammals. , 2001, Environmental science & technology.

[25]  N. Jørgensen,et al.  Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography–tandem mass spectrometry (LC–MS/MS) , 2011, Journal of Exposure Science and Environmental Epidemiology.

[26]  K. Kannan,et al.  Alkyl protocatechuates as novel urinary biomarkers of exposure to p-hydroxybenzoic acid esters (parabens). , 2013, Environment international.

[27]  T. Ameller,et al.  Systemic exposure to parabens: pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [14C]-methyl-, propyl- and butylparaben in rats after oral, topical or subcutaneous administration. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[28]  John P. Giesy,et al.  Butyltin residues in Southern Sea Otters (Enhydra lutris nereis) found dead along California coastal waters , 1998 .