Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection

[1]  P. Mermelstein,et al.  Progesterone blocks multiple routes of ion flux , 2011, Molecular and Cellular Neuroscience.

[2]  P. Mermelstein,et al.  Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity , 2011, Steroids.

[3]  Roberta Diaz Brinton,et al.  Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: Antagonism by progesterone , 2011, Brain Research.

[4]  C. Espinosa-Garcia,et al.  Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia. , 2011, Restorative neurology and neuroscience.

[5]  M. Baudry,et al.  Progesterone inhibits estrogen‐mediated neuroprotection against excitotoxicity by down‐regulating estrogen receptor‐β , 2010, Journal of neurochemistry.

[6]  J. D. Olmos,et al.  Involvement of AMPA/kainate-excitotoxicity in MK801-induced neuronal death in the retrosplenial cortex , 2010, Neuroscience.

[7]  Chao Jiang,et al.  Neuroprotective effects of progesterone following stroke in aged rats , 2010, Behavioural Brain Research.

[8]  M. Tymianski,et al.  Calcium, ischemia and excitotoxicity. , 2010, Cell calcium.

[9]  A. Prakash,et al.  Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice , 2010, Pharmacology Biochemistry and Behavior.

[10]  C. Beyer,et al.  Combined 17β‐Oestradiol and Progesterone Treatment Prevents Neuronal Cell Injury in Cortical but not Midbrain Neurones or Neuroblastoma Cells , 2009, Journal of neuroendocrinology.

[11]  T. Simoncini,et al.  Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons depending on prior hormonal exposure via the induction of neural nitric oxide synthase , 2009, Steroids.

[12]  J. Bibb,et al.  Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP , 2009, The Journal of Neuroscience.

[13]  Meharvan Singh,et al.  The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression. , 2009, Endocrinology.

[14]  D. Stein,et al.  Progesterone with Vitamin D Affords Better Neuroprotection against Excitotoxicity in Cultured Cortical Neurons than Progesterone Alone , 2009, Molecular medicine.

[15]  E. Sribnick,et al.  Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels , 2009, Brain Research.

[16]  M. S. Gold,et al.  Dihydropyridine block of voltage-dependent K+ currents in rat dorsal root ganglion neurons , 2009, Neuroscience.

[17]  M. Schumacher,et al.  Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury , 2009, Glia.

[18]  Chao Jiang,et al.  Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke , 2009, Inflammation Research.

[19]  D. Stein,et al.  Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats , 2009, Brain Research.

[20]  P. Akan,et al.  Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not. , 2009, Chemico-biological interactions.

[21]  C. Gibson,et al.  Progesterone, BDNF and Neuroprotection in the Injured CNS , 2009, The International journal of neuroscience.

[22]  J. Brosens,et al.  Non-genomic progesterone actions in female reproduction. , 2008, Human reproduction update.

[23]  V. Ozacmak,et al.  The effects of 17beta estradiol, 17alpha estradiol and progesterone on oxidative stress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia. , 2009, Physiological research.

[24]  Richard J Traystman,et al.  Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization , 2008, Journal of neurochemistry.

[25]  R. Farah,et al.  The combined effect of calcium channel blocker Lercanidipine and antioxidants on low-grade systemic inflammation parameters in essential hypertension patients. , 2008, Minerva Cardioangiologica : a Journal on Cardiovascular Pathophysiology, Clinical Medicine and Therapy.

[26]  Myron D. Ginsberg,et al.  Neuroprotection for ischemic stroke: Past, present and future , 2008, Neuropharmacology.

[27]  Guoming Xiao,et al.  Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial , 2008, Critical care.

[28]  Takeshi Hayashi,et al.  Prevention of neuronal damage by calcium channel blockers with antioxidative effects after transient focal ischemia in rats , 2007, Brain Research.

[29]  Wei-guo Liu,et al.  Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury. , 2007, Biomedical and environmental sciences : BES.

[30]  Meharvan Singh,et al.  Progesterone increases brain‐derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen‐activated protein kinase‐ and phosphoinositide‐3 kinase‐dependent manner in cerebral cortical explants , 2007, Journal of neuroscience research.

[31]  R. Vink,et al.  Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats , 2007, Experimental Neurology.

[32]  David W Wright,et al.  ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. , 2007, Annals of emergency medicine.

[33]  S. Yoloğlu,et al.  Do sodium channel blockers have neuroprotective effect after onset of ischemic insult? , 2007, Neurological research.

[34]  Q. Jiang,et al.  [Clinical study on the therapeutic effects and mechanism of progesterone in the treatment for acute severe head injury]. , 2007, Zhonghua wai ke za zhi [Chinese journal of surgery].

[35]  D. Stein,et al.  Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. , 2007, Restorative neurology and neuroscience.

[36]  M. Schumacher,et al.  Progesterone treatment of spinal cord injury , 2007, Journal of Molecular Neuroscience.

[37]  D. Stein,et al.  Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats , 2006, Experimental Neurology.

[38]  D. Stein,et al.  Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. , 2006, Annals of emergency medicine.

[39]  M. Schumacher,et al.  Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord. , 2006, Journal of neurotrauma.

[40]  R. Vink,et al.  Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats , 2005, Brain Research.

[41]  G. Moralí,et al.  Post-ischemic administration of progesterone in rats exerts neuroprotective effects on the hippocampus , 2005, Neuroscience Letters.

[42]  D. Wright,et al.  Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury , 2005, Brain Research.

[43]  E. Hall,et al.  Lack of a gender difference in post-traumatic neurodegeneration in the mouse controlled cortical impact injury model. , 2005, Journal of neurotrauma.

[44]  D. Constantin,et al.  Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia , 2005, Experimental Neurology.

[45]  A. Akaike,et al.  Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons , 2005, The European journal of neuroscience.

[46]  P. Morris,et al.  The neuroprotective effect of progesterone after traumatic brain injury in male mice is independent of both the inflammatory response and growth factor expression , 2005, The European journal of neuroscience.

[47]  M. Schumacher,et al.  Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons , 2005, The Journal of Steroid Biochemistry and Molecular Biology.

[48]  D. Stein,et al.  The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. , 2005, Journal of neurotrauma.

[49]  J. Sahel,et al.  Diltiazem-induced Neuroprotection in Glutamate Excitotoxicity and Ischemic Insult of Retinal Neurons , 2005, Documenta Ophthalmologica.

[50]  P. Das,et al.  Inhibition of type a GABA receptors by L-type calcium channel blockers , 2004, Neuroscience.

[51]  D. Stein,et al.  Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex , 2004, Neuroscience.

[52]  N. Oyesiku,et al.  Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury , 2004, Experimental Neurology.

[53]  E. Brand-Schieber,et al.  Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis , 2004, Experimental Neurology.

[54]  C. Gibson,et al.  Progesterone Enhances Functional Recovery after Middle Cerebral Artery Occlusion in Male Mice , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[55]  M. Tymianski,et al.  Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury , 2004, Cellular and Molecular Life Sciences CMLS.

[56]  P. Micevych,et al.  Estrogen Induces de novo Progesterone Synthesis in Astrocytes , 2003, Developmental Neuroscience.

[57]  D. Stein,et al.  Behavioral effects and anatomic correlates after brain injury: a progesterone dose–response study , 2003, Pharmacology Biochemistry and Behavior.

[58]  R. Brinton,et al.  Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[59]  O. Taşdemír,et al.  Does diltiazem inhibit the inflammatory response in cardiopulmonary bypass? , 2003, Medical science monitor : international medical journal of experimental and clinical research.

[60]  J. Westman,et al.  An L-type calcium channel blocker, nimodipine influences trauma induced spinal cord conduction and axonal injury in the rat. , 2003, Acta neurochirurgica. Supplement.

[61]  D. Stein,et al.  Progesterone Protects against Necrotic Damage and Behavioral Abnormalities Caused by Traumatic Brain Injury , 2002, Experimental Neurology.

[62]  P. Hurn,et al.  Progesterone Administration during Reperfusion, but not Preischemia Alone, Reduces Injury in Ovariectomized Rats , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[63]  Ding Yf,et al.  [Effect of progesterone on cerebral cortex edema in rats exposed to focal ischemia/reperfusion]. , 2001 .

[64]  D. Wright,et al.  Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. , 2001, Journal of neurotrauma.

[65]  M. Mariani,et al.  Calcium channel blockers, postural vasoconstriction and dependent oedema in essential hypertension , 2001, Journal of Human Hypertension.

[66]  Y. Itoh,et al.  Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7 I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats , 2001, Brain Research.

[67]  H. Zhao,et al.  [Effect of progesterone on cerebral cortex edema in rats exposed to focal ischemia/reperfusion]. , 2001, Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.

[68]  M. Fisher,et al.  Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat , 2000, Journal of the Neurological Sciences.

[69]  S. Sakaki,et al.  Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. , 2000, Journal of neurosurgery.

[70]  M. Chopp,et al.  Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat , 1999, Journal of the Neurological Sciences.

[71]  M. Chopp,et al.  Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. , 1999, Spine.

[72]  S. Tanaka,et al.  Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury. , 1999, Life sciences.

[73]  K. Okuyama,et al.  A novel Na+ and Ca2+ channel blocker, T-477, prevents brain edema following microsphere-induced permanent occlusion of cerebral arterioles in rats. , 1999, Japanese Journal of Pharmacology.

[74]  O. Keren,et al.  Female TBI patients recover better than males. , 1998, Brain injury.

[75]  C. Cascio,et al.  Pregnenolone sulfate modulates NMDA receptors, inducing and potentiating acute excitotoxicity in isolated retina. , 1998, Journal of neuroscience research.

[76]  J. Correale,et al.  Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model. , 1997, Journal of neurosurgery.

[77]  J. Anderson,et al.  Characterization of nifedipine block of the human heart delayed rectifier, hKv1.5. , 1997, The Journal of pharmacology and experimental therapeutics.

[78]  Michael Chopp,et al.  Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats , 1996, Brain Research.

[79]  Charles Tator,et al.  Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. , 1996, Neurosurgery.

[80]  M. Mattson,et al.  Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons , 1996, Journal of neurochemistry.

[81]  D. Stein,et al.  Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective , 1996, Experimental Neurology.

[82]  R. Busto,et al.  Glutamate Release and Free Radical Production Following Brain Injury: Effects of Posttraumatic Hypothermia , 1995, Journal of neurochemistry.

[83]  M. Myers.  Dihydropyridine calcium antagonists and the trough: peak ratio focus on adverse effects , 1994, Journal of Hypertension - Supplement.

[84]  D. Stein,et al.  Progesterone Facilitates Cognitive Recovery and Reduces Secondary Neuronal Loss Caused by Cortical Contusion Injury in Male Rats , 1994, Experimental Neurology.

[85]  B. Wilffert,et al.  Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischemia , 1994, Brain Research.

[86]  K. Kataoka,et al.  Steroid hormones protect spinal cord neurons from glutamate toxicity , 1993, Neuroscience.

[87]  D. Stein,et al.  Gender influences outcome of brain injury: progesterone plays a protective role , 1993, Brain Research.

[88]  M. Thomas,et al.  Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury. , 1992, Journal of neurosurgery.

[89]  K. Kubo,et al.  Protective effect of benidipine against the development of glomerular sclerosis in experimental nephrotic syndrome. , 1992, Japanese journal of pharmacology.

[90]  Y. Sara,et al.  Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats. , 1992, Pharmacology.

[91]  D. Stein,et al.  Progesterone treatment attenuates brain edema following contusion injury in male and female rats. , 1992, Restorative neurology and neuroscience.

[92]  A. Betz,et al.  Effect of steroids on edema and sodium uptake of the brain during focal ischemia in rats. , 1990, Stroke.

[93]  E. Baulieu,et al.  Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. , 1989, Endocrinology.

[94]  V. Moudgil,et al.  Characterization of R5020 and RU486 binding to progesterone receptor from calf uterus. , 1988, Biochemistry.

[95]  D. Choi,et al.  Glutamate neurotoxicity in cortical cell culture is calcium dependent , 1985, Neuroscience Letters.

[96]  A. Brown,et al.  The Calcium Channel Blocker Nitrendipine Blocks Sodium Channels in Neonatal Rat Cardiac Myocytes , 1985, Circulation research.

[97]  H. Selye,et al.  ADDITIONAL STEROIDS WITH LUTEOID ACTIVITY. , 1942, Science.