Occurrence of the synthetic analgesic tramadol in an African medicinal plant.

moderate to severe pain without any known side effects. [8, 9] It was designed by a simplification of the structure of morphine that kept the pharmacophoric elements responsible for the analgesic effect. Herein, we describe the isolation of tramadol from the root bark of N. latifolia, and the different methods used to prove the authenticity of its natural origin. The

[1]  P. Carrupt,et al.  High resolution ultra high pressure liquid chromatography-time-of-flight mass spectrometry dereplication strategy for the metabolite profiling of Brazilian Lippia species. , 2012, Journal of chromatography. A.

[2]  Robert M. Williams,et al.  Enantiomere Naturstoffe: Vorkommen und Biogenese , 2012 .

[3]  Robert M. Williams,et al.  Enantiomeric natural products: occurrence and biogenesis. , 2012, Angewandte Chemie.

[4]  E. Talla,et al.  Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action , 2011, Pharmaceutical biology.

[5]  B. Chindo,et al.  Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: effects against nociception, inflammation, and pyrexia in rats and mice. , 2010, Journal of ethnopharmacology.

[6]  W. Leppert.  Tramadol as an analgesic for mild to moderate cancer pain , 2009, Pharmacological reports : PR.

[7]  S. Akoka,et al.  Unexpected fractionation in site-specific 13C isotopic distribution detected by quantitative 13C NMR at natural abundance. , 2008, Journal of the American Chemical Society.

[8]  F. Courant,et al.  Correlation between the synthetic origin of methamphetamine samples and their 15N and 13C stable isotope ratios. , 2007, Analytica chimica acta.

[9]  W. Eisenreich,et al.  The prediction of isotopic patterns in phenylpropanoids from their precursors and the mechanism of the NIH-shift: basis of the isotopic characteristics of natural aromatic compounds. , 2006, Phytochemistry.

[10]  S. Buhari,et al.  Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice. , 2005, Journal of ethnopharmacology.

[11]  M. Druet‐Cabanac,et al.  Epidemiology and aetiology of epilepsy in sub-Saharan Africa , 2005, The Lancet Neurology.

[12]  C. Kong,et al.  5-Fluorouracil derivatives from the sponge Phakellia fusca. , 2003, Journal of natural products.

[13]  J. Kobayashi,et al.  Naucleamides A-E, new monoterpene indole alkaloids from Nauclea latifolia. , 2003, Chemical & pharmaceutical bulletin.

[14]  John O’Rourke,et al.  HIGHLY EFFICIENT RESOLUTION OF (±)- TRAMADOL WITH DI – P – TOLUOYL – TARTARIC ACID (DTTA) , 2001 .

[15]  M. Druet‐Cabanac,et al.  Estimation of the prevalence of epilepsy in the Benin region of Zinvié using the capture-recapture method. , 2000, International journal of epidemiology.

[16]  I. Izquierdo,et al.  Naturally occurring benzodiazepines and benzodiazepine-like molecules in brain , 1993, Behavioural Brain Research.

[17]  U. Klotz.  Occurrence of "natural" benzodiazepines. , 1991, Life sciences.

[18]  T. Jessell.  PAIN , 1982, The Lancet.