A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.

[1]  G. Waksman,et al.  Motions of the fingers subdomain of klentaq1 are fast and not rate limiting: implications for the molecular basis of fidelity in DNA polymerases. , 2005, Molecular cell.

[2]  T. Carell,et al.  Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase , 2004, Nature.

[3]  T. Kunkel,et al.  Structural basis for the dual coding potential of 8‐oxoguanosine by a high‐fidelity DNA polymerase , 2004, The EMBO journal.

[4]  S. Doublié,et al.  Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7 , 2004, Nature Structural &Molecular Biology.

[5]  K. Sakumi,et al.  ReviewThe Defense Mechanisms in Mammalian Cells against Oxidative Damage in Nucleic Acids and their Involvement in the Suppression of Mutagenesis and Cell Death , 2004, Free radical research.

[6]  T. Kunkel DNA Replication Fidelity* , 2004, Journal of Biological Chemistry.

[7]  C. Kisker,et al.  Lesion (in)tolerance reveals insights into DNA replication fidelity , 2004, The EMBO journal.

[8]  T. Kunkel,et al.  The Efficiency and Specificity of Apurinic/Apyrimidinic Site Bypass by Human DNA Polymerase η and Sulfolobus solfataricus Dpo4* , 2003, Journal of Biological Chemistry.

[9]  T. Tsuzuki,et al.  Oxidative nucleotide damage: consequences and prevention , 2002, Oncogene.

[10]  Samuel H. Wilson,et al.  Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus. , 2002, Journal of molecular biology.

[11]  D. Barnes,et al.  The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool , 2002, Current Biology.

[12]  Xiao-Ping Yang,et al.  Loss of DNA Polymerase β Stacking Interactions with Templating Purines, but Not Pyrimidines, Alters Catalytic Efficiency and Fidelity* , 2002, The Journal of Biological Chemistry.

[13]  F. Guengerich,et al.  Fidelity of Nucleotide Insertion at 8-Oxo-7,8-dihydroguanine by Mammalian DNA Polymerase δ , 2001, The Journal of Biological Chemistry.

[14]  L. Loeb,et al.  Thermus aquaticus DNA Polymerase I Mutants with Altered Fidelity , 2000, The Journal of Biological Chemistry.

[15]  L. Brieba,et al.  Misincorporation by wild-type and mutant T7 RNA polymerases: identification of interactions that reduce misincorporation rates by stabilizing the catalytically incompetent open conformation. , 2000, Biochemistry.

[16]  L. Marnett,et al.  Oxyradicals and DNA damage. , 2000, Carcinogenesis.

[17]  G. Marsischky,et al.  MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. , 1999, Molecular cell.

[18]  T. Kunkel,et al.  Side Chains That Influence Fidelity at the Polymerase Active Site of Escherichia coli DNA Polymerase I (Klenow Fragment)* , 1999, The Journal of Biological Chemistry.

[19]  S. Doublié,et al.  The mechanism of action of T7 DNA polymerase. , 1998, Current opinion in structural biology.

[20]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[21]  N. Schnetz-Boutaud,et al.  Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. , 1998, Biochemistry.

[22]  F. Guengerich,et al.  Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. , 1998, Biochemistry.

[23]  S. Doublié,et al.  Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution , 1998, Nature.

[24]  F. Guengerich,et al.  Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. , 1997, Biochemistry.

[25]  T. Kunkel,et al.  Base Miscoding and Strand Misalignment Errors by Mutator Klenow Polymerases with Amino Acid Substitutions at Tyrosine 766 in the O Helix of the Fingers Subdomain* , 1997, The Journal of Biological Chemistry.

[26]  William C. Copeland,et al.  Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase γ , 1996 .

[27]  M. Modak,et al.  Significance of the O-helix residues of Escherichia coli DNA polymerase I in DNA synthesis: dynamics of the dNTP binding pocket. , 1996, Biochemistry.

[28]  J. Carrodeguas,et al.  The γ Subfamily of DNA Polymerases: Cloning of a Developmentally Regulated cDNA Encoding Xenopus Laevis Mitochondrial DNA Polymerase γ , 1996 .

[29]  D. Bogenhagen,et al.  Action of Mitochondrial DNA Polymerase at Sites of Base Loss or Oxidative Damage (*) , 1995, The Journal of Biological Chemistry.

[30]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[31]  A. Grollman,et al.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG , 1991, Nature.

[32]  Smita S. Patel,et al.  Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. , 1991, Biochemistry.

[33]  C. Richardson,et al.  Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7. , 1987, The Journal of biological chemistry.

[34]  T. Kunkel,et al.  A closed conformation for the Pol λ catalytic cycle , 2005, Nature Structural &Molecular Biology.

[35]  Samuel H. Wilson,et al.  Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. , 2003, Structure.

[36]  W. Delano The PyMOL Molecular Graphics System , 2002 .

[37]  Z. Otwinowski,et al.  [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[38]  K. Johnson,et al.  Conformational coupling in DNA polymerase fidelity. , 1993, Annual review of biochemistry.

[39]  T. Kunkel,et al.  DNA replication fidelity. , 1992, The Journal of biological chemistry.

[40]  T. Kunkel,et al.  Fidelity of DNA synthesis. , 1982, Annual review of biochemistry.

[41]  F. Crick,et al.  Genetical Implications of the Structure of Deoxyribonucleic Acid , 1953, Nature.