Diagnostic X-ray and ultrasound exposure and risk of childhood cancer.

In a population-based case-control study of 642 childhood cancer cases and the same number of matched controls in Shanghai, China, we evaluated the relationship between diagnostic X-ray (preconception, pre- and post-natal) and antenatal ultrasound exposure and the subsequent risk of developing three major types of childhood cancer (acute leukaemia, lymphoma and brain tumours) and all childhood neoplasms combined. Consistent with previous studies, prenatal X-ray exposure was found to be associated with an 80% increased risk of childhood cancers, although the estimation was based on 4% and 2% exposed cases and controls and was only marginally statistically significant (P = 0.08). Post-natal X-ray exposure was also linked with a small elevation in the risk of all cancers and the major categories of malignancies in children. Little evidence, however, was found to relate parental preconception X-ray exposure with the subsequent cancer risk in offspring, regardless of the exposure window and the anatomical site of X-ray exposures. This study adds further to the growing literature indicating that antenatal ultrasound exposure is probably not associated with an increased risk of childhood cancer.

[1]  R. Kaczmarek,et al.  X-ray examinations during pregnancy: National Natality Surveys, 1963 and 1980. , 1989, American journal of public health.

[2]  A. Stewart.  Prenatal radiation exposure and childhood cancer. , 1971, Lancet.

[3]  H. Risch,et al.  An exploratory case-control study of brain tumors in children. , 1989, Cancer research.

[4]  I. Bross,et al.  Risk of leukemia in susceptible children exposed to preconception, in utero and postnatal radiation. , 1974, Preventive medicine.

[5]  J. A. Reese,et al.  Single strand DNA breaks in human leukocytes induced by ultrasound in vitro. , 1989, Ultrasound in medicine & biology.

[6]  P. Hopton,et al.  ULTRASOUND EXAMINATIONS IN PREGNANCY AND CHILDHOOD CANCER , 1984, The Lancet.

[7]  J. Fraumeni,et al.  A population-based case-control study of childhood leukemia in Shanghai , 1990 .

[8]  E. Knox,et al.  Pregnancy x-rays and childhood cancers: effects of exposure age and radiation dose , 1988 .

[9]  J. Waterhouse,et al.  OBSTETRIC ULTRASOUND AND CHILDHOOD MALIGNANCIES , 1984, The Lancet.

[10]  M. Gardner,et al.  Follow up study of children born to mothers resident in Seascale, West Cumbria (birth cohort). , 1987, British medical journal.

[11]  Y. Yoshimoto.  Cancer Risk Among Children of Atomic Bomb Survivors: A Review of RERF Epidemiologic Studies , 1990 .

[12]  L. Kinlen,et al.  Can paternal preconceptional radiation account for the increase of leukaemia and non-Hodgkin's lymphoma in Seascale? , 1993, BMJ.

[13]  M. Muzzoli,et al.  In vitro production of free oxygen radicals induced by pulsed ultrasounds in whole blood exposed to diagnostical frequencies and intensities. , 1991, Bollettino della Societa italiana di biologia sperimentale.

[14]  M. Nishi,et al.  A case-control study of non-T cell acute lymphoblastic leukaemia of children in Hokkaido, Japan. , 1989, Journal of epidemiology and community health.

[15]  Morton W. Miller,et al.  Confirmation of an ultrasound-induced mutation in two in-vitro mammalian cell lines. , 1990, Ultrasound in medicine & biology.

[16]  J. Mann,et al.  The Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): case control study of children with bone and soft tissue sarcomas. , 1988, British Journal of Cancer.

[17]  A M Lilienfeld,et al.  The relationship of intra-uterine radiation to subsequent mortality and development of leukemia in children. A prospective study. , 1973, American journal of epidemiology.

[18]  N. Breslow,et al.  Statistical methods in cancer research. Vol. 1. The analysis of case-control studies. , 1981 .

[19]  A J Hall,et al.  Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. , 1990, BMJ.

[20]  D. Hewitt,et al.  Malignant disease in childhood and diagnostic irradiation in utero. , 1956, Lancet.

[21]  R. Mole.  Childhood cancer after prenatal exposure to diagnostic X-ray examinations in Britain. , 1990, British Journal of Cancer.

[22]  D. Hewitt,et al.  A Survey of Childhood Malignancies , 1958, Public health reports.

[23]  J. Mann,et al.  The inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours. , 1990, British journal of neurosurgery.

[24]  S. Jablon,et al.  Studies of the mortality of A-bomb survivors. 5. Radiation dose and mortality, 1950-1970. , 1972, Radiation research.

[25]  L M Schuman,et al.  Preconception, intrauterine, and postnatal irradiation as related to leukemia. , 1966, National Cancer Institute monograph.